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Molecules 2016, 21(8), 1043;

A Versatile Axle for the Construction of Disassemblage Rotaxanes

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 30 June 2016 / Revised: 2 August 2016 / Accepted: 4 August 2016 / Published: 10 August 2016
(This article belongs to the Special Issue Host-Guest Chemistry)
Full-Text   |   PDF [1044 KB, uploaded 10 August 2016]   |  


Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC and 1H-NMR analysis. The axle is highly charged, which enhances solubility in aqueous environments, and can be readily derivatized with sensor components. The trigger was swapped in a one-pot method, which is promising for the rapid production of a series of sensors. View Full-Text
Keywords: rotaxanes; disassemble; switch; pH rotaxanes; disassemble; switch; pH

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Powers, L.A.; Smithrud, D.B. A Versatile Axle for the Construction of Disassemblage Rotaxanes. Molecules 2016, 21, 1043.

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