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Molecules 2016, 21(5), 638;

A Convenient Synthesis of 3,7′-Bisindole Derivatives

Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Guangdong Goodscend Pharm. Sci &Tech. Co., Ltd., Shantou 650091, China
Authors to whom correspondence should be addressed.
Academic Editor: Richard A. Bunce
Received: 15 March 2016 / Revised: 5 May 2016 / Accepted: 6 May 2016 / Published: 17 May 2016
(This article belongs to the Collection Heterocyclic Compounds)
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An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields. View Full-Text
Keywords: 3,7′-bisindoles; Michael addition; condensation reaction; heterocyclic ketene aminals 3,7′-bisindoles; Michael addition; condensation reaction; heterocyclic ketene aminals

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liu, T.; Zhu, H.-Y.; Luo, D.-Y.; Yan, S.-J.; Lin, J. A Convenient Synthesis of 3,7′-Bisindole Derivatives. Molecules 2016, 21, 638.

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