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Article

Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces

1
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
2
Lasers Department, National Institute for Lasers, Plasma & Materials, P. O. Box MG-36, Magurele 769231, Romania
3
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalelor Lane, Sector 5, Bucharest 77206, Romania
4
Research Institute of the University of Bucharest, ICUB, Splaiul Independentei 91-95, Bucharest 010271, Romania
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Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
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Research Center for Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
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Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
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Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology “NicolaeSimionescu” (ICBP), Bucharest 050568, Romania
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Department of Electrical & Electronics Engineering, IDEALAB, Koç University, Rumeli Feneri Yolu, Sariyer, Istanbul 34450, Turkey
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(2), 220; https://doi.org/10.3390/molecules21020220
Received: 12 January 2016 / Revised: 3 February 2016 / Accepted: 5 February 2016 / Published: 16 February 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections. View Full-Text
Keywords: cyclodextrins; zinc oxide; drug delivery; MAPLE; modified surface; biofilm inhibition cyclodextrins; zinc oxide; drug delivery; MAPLE; modified surface; biofilm inhibition
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MDPI and ACS Style

Oprea, A.E.; Pandel, L.M.; Dumitrescu, A.M.; Andronescu, E.; Grumezescu, V.; Chifiriuc, M.C.; Mogoantă, L.; Bălşeanu, T.-A.; Mogoşanu, G.D.; Socol, G.; Grumezescu, A.M.; Iordache, F.; Maniu, H.; Chirea, M.; Holban, A.M. Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules 2016, 21, 220. https://doi.org/10.3390/molecules21020220

AMA Style

Oprea AE, Pandel LM, Dumitrescu AM, Andronescu E, Grumezescu V, Chifiriuc MC, Mogoantă L, Bălşeanu T-A, Mogoşanu GD, Socol G, Grumezescu AM, Iordache F, Maniu H, Chirea M, Holban AM. Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules. 2016; 21(2):220. https://doi.org/10.3390/molecules21020220

Chicago/Turabian Style

Oprea, Alexandra E.; Pandel, Loredana M.; Dumitrescu, Ana M.; Andronescu, Ecaterina; Grumezescu, Valentina; Chifiriuc, Mariana C.; Mogoantă, Laurenţiu; Bălşeanu, Tudor-Adrian; Mogoşanu, George D.; Socol, Gabriel; Grumezescu, Alexandru M.; Iordache, Florin; Maniu, Horia; Chirea, Mariana; Holban, Alina M. 2016. "Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces" Molecules 21, no. 2: 220. https://doi.org/10.3390/molecules21020220

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