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Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities

Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(11), 1481;
Received: 17 September 2016 / Revised: 2 November 2016 / Accepted: 4 November 2016 / Published: 7 November 2016
PDF [718 KB, uploaded 7 November 2016]


One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50 values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65. View Full-Text
Keywords: Ainsliaea yunnanensis; triterpenoids; NMR; structures; activity Ainsliaea yunnanensis; triterpenoids; NMR; structures; activity

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Li, J.; Zhang, B.; Liu, H.; Zhang, X.; Shang, X.; Zhao, C. Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities. Molecules 2016, 21, 1481.

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