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Molecules 2015, 20(11), 20426-20433;

Essential Oil Composition, Antioxidant, Cytotoxic and Antiviral Activities of Teucrium pseudochamaepitys Growing Spontaneously in Tunisia

Research Unit Applied Chemistry and Environment 13ES63, Faculty of Sciences of Monastir, Monastir University, 5000 Monastir, Tunisia
Laboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy of Monastir, Avenue Avicenne, 5000 Monastir, Tunisia
Laboratory of Botany and Plant Ecology, Faculty of Sciences, University of Bizerta, Jarzouna, 7021 Bizerta, Tunisia
Department of Phytochemistry, Regional Medical Research Centre (Indian Council of Medical Research), Belgaum, Karnataka-590010, India
Author to whom correspondence should be addressed.
Academic Editor: Luca Forti
Received: 21 September 2015 / Revised: 2 November 2015 / Accepted: 3 November 2015 / Published: 16 November 2015
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
PDF [739 KB, uploaded 16 November 2015]


The chemical composition, antioxidant, cytotoxic and antiviral activities of the essential oil obtained by hydrodistillation from the aerial parts of Teucrium pseudochamaepitys (Lamiaceae) collected from Zaghouan province of Tunisia are reported. The essential oil was analyzed by gas chromatography equipped with a flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). Thirty-one compounds were identified representing 88.6% of the total essential oil. Hexadecanoic acid was found to be the most abundant component (26.1%) followed by caryophyllene oxide (6.3%), myristicin (4.9%) and α-cubebene (3.9%). The antioxidant capacity of the oil was measured on the basis of the scavenging activity to the stable 2,2-diphenyl-1-picrylhydrazyl (DPPH). The IC50 value of the oil was evaluated as 0.77 mg·mL−1. In addition, the essential oil was found to possess moderate cytotoxic effects on the HEp-2 cell line (50% cytotoxic concentration (CC50) = 653.6 µg·mL−1). The potential antiviral effect was tested against Coxsackievirus B (CV-B), a significant human and mouse pathogen that causes pediatric central nervous system disease, commonly with acute syndromes. The reduction of viral infectivity by the essential oil was measured using a cytopathic (CPE) reduction assay. View Full-Text
Keywords: Teucrium pseudochamaepitys; chemistry; antioxidant; cytotoxic; antiviral Teucrium pseudochamaepitys; chemistry; antioxidant; cytotoxic; antiviral

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hammami, S.; Jmii, H.; Mokni, R.E.; Khmiri, A.; Faidi, K.; Dhaouadi, H.; Aouni, M.H.E.; Aouni, M.; Joshi, R.K. Essential Oil Composition, Antioxidant, Cytotoxic and Antiviral Activities of Teucrium pseudochamaepitys Growing Spontaneously in Tunisia. Molecules 2015, 20, 20426-20433.

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