Next Article in Journal
Concerted Halogen Bonding and Orthogonal Metal-Halogen Interactions in Dimers of Lithium Formamidinate and Halogenated Formamidines: An ab Initio Study
Previous Article in Journal
Microbiological and Nutritional Quality of the Goat Meat by-Product “Sarapatel”
Article Menu

Export Article

Open AccessCommunication
Molecules 2014, 19(1), 1060-1068;

Analgesic Effect of Harpagophytum procumbens on Postoperative and Neuropathic Pain in Rats

Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Korea
These authors contributed equally in this work.
Author to whom correspondence should be addressed.
Received: 12 December 2013 / Revised: 10 January 2014 / Accepted: 13 January 2014 / Published: 16 January 2014
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [894 KB, uploaded 18 June 2014]   |  


Harpagophytum procumbens, also known as Devil’s Claw, has historically been used to treat a wide range of conditions, including pain and arthritis. The study was designed to investigate whether H. procumbens extracts exhibit analgesic effects in plantar incision and spared nerve injury (SNI) rats. The whole procedure was performed on male SD rats. To evaluate pain-related behavior, we performed the mechanical withdrawal threshold (MWT) test measured by von Frey filaments. Pain-related behavior was also determined through analysis of ultrasonic vocalization (USVs). The results of experiments showed MWT values of the group that was treated with 300 mg/kg H. procumbens extract increased significantly; on the contrary, the number of 22–27 kHz USVs of the treated group was reduced at 6 h and 24 h after plantar incision operation. After 21 days of continuous treatment with H. procumbens extracts at 300 mg/kg, the treated group showed significantly alleviated SNI-induced hypersensitivity responses by MWT, compared with the control group. These results suggest that H. procumbens extracts have potential analgesic effects in the case of acute postoperative pain and chronic neuropathic pain in rats. View Full-Text
Keywords: Harpagophytum procumbens; pain; hyperalgesia; allodynia; ultrasonic vocalization Harpagophytum procumbens; pain; hyperalgesia; allodynia; ultrasonic vocalization

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Lim, D.W.; Kim, J.G.; Han, D.; Kim, Y.T. Analgesic Effect of Harpagophytum procumbens on Postoperative and Neuropathic Pain in Rats. Molecules 2014, 19, 1060-1068.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top