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Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
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Molecules 2012, 17(12), 14146-14158; https://doi.org/10.3390/molecules171214146
Received: 23 October 2012 / Revised: 12 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Molecular Diversity)
An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure. View Full-Text
Keywords: chroman-2,4-diones; multicomponent reactions (MCRs); ultrasonic irradiation; green chemistry; coumarin; edaravone chroman-2,4-diones; multicomponent reactions (MCRs); ultrasonic irradiation; green chemistry; coumarin; edaravone
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Liang, C.; Jiang, H.; Zhou, Z.; Lei, D.; Xue, Y.; Yao, Q. Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation. Molecules 2012, 17, 14146-14158.

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