Next Article in Journal
In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer
Previous Article in Journal
Platycoside O, a New Triterpenoid Saponin from the Roots of Platycodon grandiflorum
Article Menu

Export Article

Open AccessArticle
Molecules 2011, 16(6), 4379-4388;

Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins

Department of Organic Chemistry, Faculty of Chemistry, University of Vigo, 36310 Vigo, Spain
Author to whom correspondence should be addressed.
Received: 26 April 2011 / Revised: 18 May 2011 / Accepted: 19 May 2011 / Published: 27 May 2011
Full-Text   |   PDF [174 KB, uploaded 18 June 2014]   |  


The ionic liquid 1,3-dimethylimidazolium methyl sulfate, [MMIm][MSO4], together with a small amount of water (the amount taken up by the ionic liquid upon exposure to air), acts efficiently as both solvent and catalyst of the Knoevenagel condensation reactions of malononitrile with 4-substituted benzaldehydes, without the need for any other solvent or promoter, affording yields of 92%–99% within 2–7 min at room temperature. When L-proline is used as an additional promoter to obtain coumarins from o-hydroxybenzaldehydes, the reaction also proceeds in high yields. Work-up is very simple and the ionic liquid can be reused several times. Some of the coumarins obtained are described for the first time. View Full-Text
Keywords: ionic liquid; Knoevenagel reaction; synthesis; coumarins ionic liquid; Knoevenagel reaction; synthesis; coumarins

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Verdía, P.; Santamarta, F.; Tojo, E. Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins. Molecules 2011, 16, 4379-4388.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top