Next Article in Journal
Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
Next Article in Special Issue
High Affinity, Developability and Functional Size: The Holy Grail of Combinatorial Antibody Library Generation
Previous Article in Journal
Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails
Previous Article in Special Issue
Lambda-Display: A Powerful Tool for Antigen Discovery
Article Menu

Export Article

Open AccessReview
Molecules 2011, 16(5), 3499-3518;

Phage Display of Combinatorial Peptide Libraries: Application to Antiviral Research

Unité Postulante des Stratégies Antivirales, CNRS URA-3015, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Author to whom correspondence should be addressed.
Received: 12 March 2011 / Revised: 21 April 2011 / Accepted: 22 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Phage Display of Combinatorial Libraries)
Full-Text   |   PDF [292 KB, uploaded 18 June 2014]   |  


Given the growing number of diseases caused by emerging or endemic viruses, original strategies are urgently required: (1) for the identification of new drugs active against new viruses and (2) to deal with viral mutants in which resistance to existing antiviral molecules has been selected. In this context, antiviral peptides constitute a promising area for disease prevention and treatment. The identification and development of these inhibitory peptides require the high-throughput screening of combinatorial libraries. Phage-display is a powerful technique for selecting unique molecules with selective affinity for a specific target from highly diverse combinatorial libraries. In the last 15 years, the use of this technique for antiviral purposes and for the isolation of candidate inhibitory peptides in drug discovery has been explored. We present here a review of the use of phage display in antiviral research and drug discovery, with a discussion of optimized strategies combining the strong screening potential of this technique with complementary rational approaches for identification of the best target. By combining such approaches, it should be possible to maximize the selection of molecules with strong antiviral potential. View Full-Text
Keywords: phage-display; antiviral; peptide phage-display; antiviral; peptide

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Castel, G.; Chtéoui, M.; Heyd, B.; Tordo, N. Phage Display of Combinatorial Peptide Libraries: Application to Antiviral Research. Molecules 2011, 16, 3499-3518.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top