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Molecules 2011, 16(5), 3519-3529;

Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002

Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 210-340, Korea
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea
Author to whom correspondence should be addressed.
Received: 29 March 2011 / Revised: 19 April 2011 / Accepted: 20 April 2011 / Published: 26 April 2011
(This article belongs to the Collection Bioactive Compounds)
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Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be α-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA. View Full-Text
Keywords: Streptomyces; gombapyrone; α-pyrone; polyene Streptomyces; gombapyrone; α-pyrone; polyene

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Park, H.B.; Yang, H.O.; Lee, K.R.; Kwon, H.C. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules 2011, 16, 3519-3529.

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