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Molecules 2010, 15(10), 6941-6947;

Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China
Author to whom correspondence should be addressed.
Received: 4 August 2010 / Revised: 6 September 2010 / Accepted: 25 September 2010 / Published: 8 October 2010
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A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment.
Keywords: acyl; thiourea; deparasitization; Nippostrongylus brazilliensis acyl; thiourea; deparasitization; Nippostrongylus brazilliensis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Duan, L.-P.; Xue, J.; Xu, L.-L.; Zhang, H.-B. Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs. Molecules 2010, 15, 6941-6947.

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