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Novel Aflatoxin Derivatives and Protein Conjugates

Institute of Hydrochemistry, Chair for Analytical Chemistry, Technische Universität München, Marchioninistrasse 17, 81377 München, Germany;
Federal Institute for Materials Research and Testing (BAM), Division I.5 (Bioanalytics), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany
Author to whom correspondence should be addressed.
Molecules 2007, 12(3), 641-653;
Received: 14 March 2007 / Revised: 25 March 2007 / Accepted: 26 March 2007 / Published: 27 March 2007
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Aflatoxins, a group of structurally related mycotoxins, are well known for their toxic and carcinogenic effects in humans and animals. Aflatoxin derivatives and protein conjugates are needed for diverse analytical applications. This work describes a reliable and fast synthesis of novel aflatoxin derivatives, purification by preparative HPLC and characterisation by ESI-MS and one- and two-dimensional NMR. Novel aflatoxin bovine serum albumin conjugates were prepared and characterised by UV absorption and MALDI-MS. These aflatoxin protein conjugates are potentially interesting as immunogens for the generation of aflatoxin selective antibodies with novel specificities. View Full-Text
Keywords: Aflatoxin; mycotoxin; hapten; protein conjugation; immunogen; antigen; antibody Aflatoxin; mycotoxin; hapten; protein conjugation; immunogen; antigen; antibody

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Cervino, C.; Knopp, D.; Weller, M.G.; Niessner, R. Novel Aflatoxin Derivatives and Protein Conjugates. Molecules 2007, 12, 641-653.

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