Topical Collection "Molecular Mechanisms of Human Liver Diseases"
A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Many different liver diseases are known until now. In addition to virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis, as well as acute and chronic liver failure are the most prominent amongst them.
NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH), which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation, which underlines the clinical significance of this disease complex.
Wilson’s disease, which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.
In this Topical Collection, an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways, and mechanisms of these diseases is given.
Dr. Johannes Haybaeck
Manuscript Submission Information
Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.
- non-alcoholic fatty liver disease (NAFLD)
- non-alcoholic steatohepatitis (NASH)
- alcoholic steatohepatitis (ASH) Wilson’s disease
- viral hepatitis
- autoimmune hepatitis
- hepatocellular carcinoma
- signaling pathways
- molecular mechanisms