Special Issue "Molecular Mechanisms of Human Liver Diseases"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (28 February 2014)

Special Issue Editor

Guest Editor
Dr. Johannes Haybaeck
Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
Website: http://www.meduni-graz.at/pathologie/1382
E-Mail: johannes.haybaeck@medunigraz.at
Interests: molecular pathology; neuropathology; hepatopathology; tumor animal models

Special Issue Information

Dear Colleagues,

Many different liver diseases are known until now. Besides virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis as well as acute and chronic liver failure are the most prominent amongst them.

NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH) which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation which underlines the clinical significance of this disease complex.

Wilson’s disease which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.

In this issue an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways and mechanisms of these diseases is given.

Dr. Johannes Haybaeck
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Many different liver diseases are known until now. Besides virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis as well as acute and chronic liver failure are the most prominent amongst them.

NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH) which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation which underlines the clinical significance of this disease complex.

Wilson’s disease which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.

In this issue an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways and mechanisms of these diseases is given.

Keywords

  • non-alcoholic fatty liver disease (NAFLD)
  • non-alcoholic steatohepatitis (NASH)
  • alcoholic steatohepatitis (ASH) Wilson’s disease
  • hematochromatosis
  • viral hepatitis
  • autoimmune hepatitis
  • hepatocellular carcinoma
  • signaling pathways
  • molecular mechanisms

Published Papers (11 papers)

Int. J. Mol. Sci. 2014, 15(4), 5762-5773; doi:10.3390/ijms15045762
Received: 27 February 2014; in revised form: 17 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
Show/Hide Abstract | Download PDF Full-text (4528 KB)

Int. J. Mol. Sci. 2014, 15(4), 5199-5220; doi:10.3390/ijms15045199
Received: 5 February 2014; in revised form: 7 March 2014 / Accepted: 17 March 2014 / Published: 25 March 2014
Show/Hide Abstract | Download PDF Full-text (416 KB)

Int. J. Mol. Sci. 2014, 15(3), 5163-5174; doi:10.3390/ijms15035163
Received: 27 October 2013; in revised form: 24 February 2014 / Accepted: 10 March 2014 / Published: 24 March 2014
Show/Hide Abstract | Download PDF Full-text (843 KB) | Download XML Full-text

Int. J. Mol. Sci. 2014, 15(3), 4747-4779; doi:10.3390/ijms15034747
Received: 14 February 2014; in revised form: 7 March 2014 / Accepted: 12 March 2014 / Published: 18 March 2014
Show/Hide Abstract | Download PDF Full-text (696 KB) | Download XML Full-text

Int. J. Mol. Sci. 2014, 15(3), 4060-4076; doi:10.3390/ijms15034060
Received: 2 January 2014; in revised form: 20 February 2014 / Accepted: 27 February 2014 / Published: 6 March 2014
Show/Hide Abstract | Download PDF Full-text (3179 KB) | Download XML Full-text |  Supplementary Files

Int. J. Mol. Sci. 2014, 15(3), 4019-4030; doi:10.3390/ijms15034019
Received: 14 January 2014; in revised form: 11 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014
Show/Hide Abstract | Download PDF Full-text (428 KB) | Download XML Full-text

Int. J. Mol. Sci. 2014, 15(2), 2892-2905; doi:10.3390/ijms15022892
Received: 28 January 2014; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 19 February 2014
Show/Hide Abstract | Download PDF Full-text (282 KB) | Download XML Full-text

Int. J. Mol. Sci. 2013, 14(12), 24230-24241; doi:10.3390/ijms141224230
Received: 29 October 2013; in revised form: 2 December 2013 / Accepted: 9 December 2013 / Published: 13 December 2013
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Int. J. Mol. Sci. 2013, 14(12), 23700-23710; doi:10.3390/ijms141223700
Received: 11 September 2013; in revised form: 21 November 2013 / Accepted: 21 November 2013 / Published: 4 December 2013
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Int. J. Mol. Sci. 2013, 14(11), 21873-21886; doi:10.3390/ijms141121873
Received: 12 September 2013; in revised form: 17 October 2013 / Accepted: 23 October 2013 / Published: 5 November 2013
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Int. J. Mol. Sci. 2013, 14(10), 20877-20889; doi:10.3390/ijms141020877
Received: 28 August 2013; in revised form: 8 October 2013 / Accepted: 14 October 2013 / Published: 17 October 2013
Show/Hide Abstract | Download PDF Full-text (2278 KB) | View HTML Full-text | Download XML Full-text

Last update: 6 August 2013

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