Topical Collection "Molecular Mechanisms of Human Liver Diseases"

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A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Molecular Pathology".

Editor

Collection Editor
Dr. Johannes Haybaeck
Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
Website: http://www.meduni-graz.at/pathologie/1382
E-Mail: johannes.haybaeck@medunigraz.at
Interests: molecular pathology; neuropathology; hepatopathology; tumor animal models

Topical Collection Information

Dear Colleagues,

Many different liver diseases are known until now. Besides virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis as well as acute and chronic liver failure are the most prominent amongst them.

NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH) which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation which underlines the clinical significance of this disease complex.

Wilson’s disease which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.

In this issue an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways and mechanisms of these diseases is given.

Dr. Johannes Haybaeck
Collection Editor

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Many different liver diseases are known until now. Besides virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis as well as acute and chronic liver failure are the most prominent amongst them.

NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH) which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation which underlines the clinical significance of this disease complex.

Wilson’s disease which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.

In this issue an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways and mechanisms of these diseases is given.

Keywords

  • non-alcoholic fatty liver disease (NAFLD)
  • non-alcoholic steatohepatitis (NASH)
  • alcoholic steatohepatitis (ASH) Wilson’s disease
  • hematochromatosis
  • viral hepatitis
  • autoimmune hepatitis
  • hepatocellular carcinoma
  • signaling pathways
  • molecular mechanisms

Published Papers (27 papers)


2014  ( 23 papers )


2013  ( 4 papers )


2014
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 12442-12457; doi:10.3390/ijms150712442
Received: 7 April 2014; in revised form: 19 June 2014 / Accepted: 20 June 2014 / Published: 14 July 2014
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 11294-11306; doi:10.3390/ijms150711294
Received: 28 February 2014; in revised form: 12 June 2014 / Accepted: 16 June 2014 / Published: 25 June 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(6), 11142-11160; doi:10.3390/ijms150611142
Received: 2 April 2014; in revised form: 12 June 2014 / Accepted: 16 June 2014 / Published: 20 June 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(6), 10578-10604; doi:10.3390/ijms150610578
Received: 4 May 2014; in revised form: 9 June 2014 / Accepted: 9 June 2014 / Published: 12 June 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(6), 9924-9944; doi:10.3390/ijms15069924
Received: 14 February 2014; in revised form: 1 May 2014 / Accepted: 20 May 2014 / Published: 3 June 2014
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by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 9422-9458; doi:10.3390/ijms15069422
Received: 7 March 2014; in revised form: 13 May 2014 / Accepted: 14 May 2014 / Published: 27 May 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 9360-9371; doi:10.3390/ijms15069360
Received: 16 March 2014; in revised form: 6 May 2014 / Accepted: 12 May 2014 / Published: 27 May 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 9184-9208; doi:10.3390/ijms15069184
Received: 30 March 2014; in revised form: 15 May 2014 / Accepted: 15 May 2014 / Published: 26 May 2014
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by  and
Int. J. Mol. Sci. 2014, 15(5), 8713-8742; doi:10.3390/ijms15058713
Received: 4 March 2014; in revised form: 4 May 2014 / Accepted: 7 May 2014 / Published: 15 May 2014
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by , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(5), 8004-8023; doi:10.3390/ijms15058004
Received: 26 February 2014; in revised form: 14 April 2014 / Accepted: 15 April 2014 / Published: 7 May 2014
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by  and
Int. J. Mol. Sci. 2014, 15(5), 7711-7730; doi:10.3390/ijms15057711
Received: 20 February 2014; in revised form: 30 April 2014 / Accepted: 30 April 2014 / Published: 5 May 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(5), 7500-7512; doi:10.3390/ijms15057500
Received: 24 February 2014; in revised form: 26 March 2014 / Accepted: 3 April 2014 / Published: 30 April 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(5), 7352-7379; doi:10.3390/ijms15057352
Received: 1 March 2014; in revised form: 28 March 2014 / Accepted: 10 April 2014 / Published: 29 April 2014
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(5), 7213-7224; doi:10.3390/ijms15057213
Received: 25 February 2014; in revised form: 26 March 2014 / Accepted: 28 March 2014 / Published: 25 April 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 7004-7028; doi:10.3390/ijms15047004
Received: 5 March 2014; in revised form: 2 April 2014 / Accepted: 9 April 2014 / Published: 22 April 2014
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by , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6556-6568; doi:10.3390/ijms15046556
Received: 25 February 2014; in revised form: 28 March 2014 / Accepted: 3 April 2014 / Published: 17 April 2014
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by , , , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 5762-5773; doi:10.3390/ijms15045762
Received: 27 February 2014; in revised form: 17 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(4), 5199-5220; doi:10.3390/ijms15045199
Received: 5 February 2014; in revised form: 7 March 2014 / Accepted: 17 March 2014 / Published: 25 March 2014
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by  and
Int. J. Mol. Sci. 2014, 15(3), 5163-5174; doi:10.3390/ijms15035163
Received: 27 October 2013; in revised form: 24 February 2014 / Accepted: 10 March 2014 / Published: 24 March 2014
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by  and
Int. J. Mol. Sci. 2014, 15(3), 4747-4779; doi:10.3390/ijms15034747
Received: 14 February 2014; in revised form: 7 March 2014 / Accepted: 12 March 2014 / Published: 18 March 2014
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4060-4076; doi:10.3390/ijms15034060
Received: 2 January 2014; in revised form: 20 February 2014 / Accepted: 27 February 2014 / Published: 6 March 2014
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by , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4019-4030; doi:10.3390/ijms15034019
Received: 14 January 2014; in revised form: 11 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(2), 2892-2905; doi:10.3390/ijms15022892
Received: 28 January 2014; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 19 February 2014
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2013
by , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 24230-24241; doi:10.3390/ijms141224230
Received: 29 October 2013; in revised form: 2 December 2013 / Accepted: 9 December 2013 / Published: 13 December 2013
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 23700-23710; doi:10.3390/ijms141223700
Received: 11 September 2013; in revised form: 21 November 2013 / Accepted: 21 November 2013 / Published: 4 December 2013
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by , ,  and
Int. J. Mol. Sci. 2013, 14(11), 21873-21886; doi:10.3390/ijms141121873
Received: 12 September 2013; in revised form: 17 October 2013 / Accepted: 23 October 2013 / Published: 5 November 2013
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20877-20889; doi:10.3390/ijms141020877
Received: 28 August 2013; in revised form: 8 October 2013 / Accepted: 14 October 2013 / Published: 17 October 2013
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Last update: 12 May 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert