Special Issue "Molecular Mechanisms of Human Liver Diseases"
Deadline for manuscript submissions: closed (28 February 2014)
Dr. Johannes Haybaeck
Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
Interests: molecular pathology; neuropathology; hepatopathology; tumor animal models
Many different liver diseases are known until now. Besides virus induced and autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), storage diseases like Wilson’s disease and hematochromatosis as well as acute and chronic liver failure are the most prominent amongst them.
NAFLD which includes steatohepatitis and steatosis, in particular non-alcoholic steatohepatitis (NASH) which should be separated from alcoholic steatohepatitis (ASH) is a rising health problem world-wide. Development of steatosis, liver fibrosis and cirrhosis often progresses towards hepatocellular carcinogenesis, and frequently consequents into the indication of liver transplantation which underlines the clinical significance of this disease complex.
Wilson’s disease which is a morbidly heightened copper accumulation and hematochromatosis showing an aggregation of iron lead also both to cirrhosis. Whereas acute liver failure originates from multiple reasons in a short time, for chronic liver failure a HBV, HCV or excessive alcohol intake is preceded for a long time span.
In this issue an overview about the currently available knowledge and recent findings regarding the development, progression, molecular pathways and mechanisms of these diseases is given.
Dr. Johannes Haybaeck
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- non-alcoholic fatty liver disease (NAFLD)
- non-alcoholic steatohepatitis (NASH)
- alcoholic steatohepatitis (ASH) Wilson’s disease
- viral hepatitis
- autoimmune hepatitis
- hepatocellular carcinoma
- signaling pathways
- molecular mechanisms
Article: Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans
Int. J. Mol. Sci. 2013, 14(10), 20877-20889; doi:10.3390/ijms141020877
Received: 28 August 2013; in revised form: 8 October 2013 / Accepted: 14 October 2013 / Published: 17 October 2013| Download PDF Full-text (2278 KB) | Download XML Full-text
Int. J. Mol. Sci. 2013, 14(11), 21873-21886; doi:10.3390/ijms141121873
Received: 12 September 2013; in revised form: 17 October 2013 / Accepted: 23 October 2013 / Published: 5 November 2013| Download PDF Full-text (2196 KB) | Download XML Full-text
Article: Smad3 Deficiency Ameliorates Hepatic Fibrogenesis through the Expression of Senescence Marker Protein-30, an Antioxidant-Related Protein
Int. J. Mol. Sci. 2013, 14(12), 23700-23710; doi:10.3390/ijms141223700
Received: 11 September 2013; in revised form: 21 November 2013 / Accepted: 21 November 2013 / Published: 4 December 2013| Download PDF Full-text (1643 KB) | Download XML Full-text | Supplementary Files
Article: CXCL10 Decreases GP73 Expression in Hepatoma Cells at the Early Stage of Hepatitis C Virus (HCV) Infection
Int. J. Mol. Sci. 2013, 14(12), 24230-24241; doi:10.3390/ijms141224230
Received: 29 October 2013; in revised form: 2 December 2013 / Accepted: 9 December 2013 / Published: 13 December 2013| Download PDF Full-text (1586 KB) | Download XML Full-text
Int. J. Mol. Sci. 2014, 15(2), 2892-2905; doi:10.3390/ijms15022892
Received: 28 January 2014; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 19 February 2014| Download PDF Full-text (282 KB)
Int. J. Mol. Sci. 2014, 15(3), 4019-4030; doi:10.3390/ijms15034019
Received: 14 January 2014; in revised form: 11 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014| Download PDF Full-text (428 KB)
Article: Long Non-Coding RNA HOTAIR Promotes Cell Migration and Invasion via Down-Regulation of RNA Binding Motif Protein 38 in Hepatocellular Carcinoma Cells
Int. J. Mol. Sci. 2014, 15(3), 4060-4076; doi:10.3390/ijms15034060
Received: 2 January 2014; in revised form: 20 February 2014 / Accepted: 27 February 2014 / Published: 6 March 2014| Download PDF Full-text (3179 KB) | Supplementary Files
Last update: 6 August 2013