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Int. J. Mol. Sci. 2016, 17(12), 2007; doi:10.3390/ijms17122007

Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?

Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital, Theodor-Stern Kai 7, 60590 Frankfurt am Main, Germany
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Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 30 September 2016 / Revised: 22 November 2016 / Accepted: 23 November 2016 / Published: 1 December 2016
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
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Abstract

Autoimmune hepatitis (AIH) is characterized by a progressive destruction of the liver parenchyma and a chronic fibrosis. The current treatment of autoimmune hepatitis is still largely dependent on the administration of corticosteroids and cytostatic drugs. For a long time the development of novel therapeutic strategies has been hampered by a lack of understanding the basic immunopathogenic mechanisms of AIH and the absence of valid animal models. However, in the past decade, knowledge from clinical observations in AIH patients and the development of innovative animal models have led to a situation where critical factors driving the disease have been identified and alternative treatments are being evaluated. Here we will review the insight on the immunopathogenesis of AIH as gained from clinical observation and from animal models. View Full-Text
Keywords: AIH immunopathogenesis; autoantibodies; T cells; cytokines; chemokines: CYP2D6 model AIH immunopathogenesis; autoantibodies; T cells; cytokines; chemokines: CYP2D6 model
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Christen, U.; Hintermann, E. Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models? Int. J. Mol. Sci. 2016, 17, 2007.

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