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Int. J. Mol. Sci. 2014, 15(2), 2892-2905; doi:10.3390/ijms15022892
Review

NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry

1,* , 2,3
, 4
 and 1
Received: 28 January 2014; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 19 February 2014
(This article belongs to the collection Molecular Mechanisms of Human Liver Diseases)
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Abstract: Chronic hepatitis B virus (HBV) infection, affecting approximately 240 million people worldwide, is a major public health problem that elevates the risk of developing liver cirrhosis and hepatocellular carcinoma. Given that current anti-HBV drugs are limited to interferon-based regimens and nucleos(t)ide analogs, the development of new anti-HBV agents is urgently needed. The viral entry process is generally an attractive target implicated in antiviral strategies. Using primary cells from humans and Tupaia belangeri, as well as HepaRG cells, important determinants of viral entry have been achieved. Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection. This finding will allow a deeper understanding of the requirements for efficient HBV infection, including the elucidation of the molecular entry mechanism. In addition, pharmacological studies suggest that NTCP is able to serve as a therapeutic target. This article summarizes our current knowledge on the mechanisms of HBV entry and the role of NTCP in this process.
Keywords: HBV; infection; entry; replication; NTCP; SLC10A1; transporter; DMSO; myrcludex-B; cyclosporin HBV; infection; entry; replication; NTCP; SLC10A1; transporter; DMSO; myrcludex-B; cyclosporin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Watashi, K.; Urban, S.; Li, W.; Wakita, T. NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry. Int. J. Mol. Sci. 2014, 15, 2892-2905.

AMA Style

Watashi K, Urban S, Li W, Wakita T. NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry. International Journal of Molecular Sciences. 2014; 15(2):2892-2905.

Chicago/Turabian Style

Watashi, Koichi; Urban, Stephan; Li, Wenhui; Wakita, Takaji. 2014. "NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry." Int. J. Mol. Sci. 15, no. 2: 2892-2905.



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