Int. J. Mol. Sci. 2014, 15(5), 8713-8742; doi:10.3390/ijms15058713

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

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Received: 4 March 2014; in revised form: 4 May 2014 / Accepted: 7 May 2014 / Published: 15 May 2014
(This article belongs to the collection Molecular Mechanisms of Human Liver Diseases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and sirtuins in development and progression of NAFLD.
Keywords: NAFLD; NASH; mitochondria; liver; steatosis; fatty acid oxidation; PGC-1α; sirtuin-1 (SIRT1); sirtuin-3 (SIRT3)
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MDPI and ACS Style

Nassir, F.; Ibdah, J.A. Role of Mitochondria in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2014, 15, 8713-8742.

AMA Style

Nassir F, Ibdah JA. Role of Mitochondria in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences. 2014; 15(5):8713-8742.

Chicago/Turabian Style

Nassir, Fatiha; Ibdah, Jamal A. 2014. "Role of Mitochondria in Nonalcoholic Fatty Liver Disease." Int. J. Mol. Sci. 15, no. 5: 8713-8742.

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