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Int. J. Mol. Sci. 2017, 18(5), 1043; doi:10.3390/ijms18051043

HepPar1-Positive Circulating Microparticles Are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection

1
Division of Internal Medicine and Gastroenterology, Catholic University School of Medicine, A. Gemelli University Hospital, Rome 00168, Italy
2
Division of Vascular Medicine, Catholic University School of Medicine, A. Gemelli University Hospital, Rome 00168, Italy
3
Hepatobiliary Surgery Unit, and Catholic University School of Medicine, A. Gemelli University Hospital, Rome 00168, Italy
4
Department of Pathology, Catholic University School of Medicine, A. Gemelli University Hospital, Rome 00168, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 10 February 2017 / Revised: 14 April 2017 / Accepted: 1 May 2017 / Published: 12 May 2017
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
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Abstract

Circulating microparticles (MPs) are novel potential biomarkers in cancer patients. Their role in hepatocellular carcinoma (HCC) is under intensive investigation. In this study, we tested the hypothesis that MPs expressing the antigen HepPar1 are increased in the blood of subjects with HCC and may serve as markers of early recurrence after liver resection (LR). We studied 15 patients affected by HCC undergoing LR, and used flow cytometry to assess the number of circulating HepPar1+ MPs. Ten subjects without HCC (five with liver cirrhosis and five with healthy livers) were used as controls. After LR, HCC patients underwent a follow-up to check for early recurrence, which occurred in seven cases. The number of circulating HepPar1+ MPs was significantly higher in subjects affected by HCC, compared to individuals without cancer (p < 0.01). We also found that, among HCC patients, the number of circulating HepPar1+ MPs, measured before LR, was significantly higher in those who displayed early recurrence compared to those without recurrence (p = 0.02). Of note, other types of circulating MPs, such as those derived from endothelial cells (CD144+) or those produced by the activated endothelium (CD144+/CD62+), were not associated with HCC, nor could they predict HCC recurrence. HepPar1+ MPs deserve further investigation as novel biomarkers of disease and prognosis in HCC patients. View Full-Text
Keywords: microparticles; biomarkers; hepatocellular carcinoma microparticles; biomarkers; hepatocellular carcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abbate, V.; Marcantoni, M.; Giuliante, F.; Vecchio, F.M.; Gatto, I.; Mele, C.; Saviano, A.; Arciuolo, D.; Gaetani, E.; Ferrari, M.C.; Giarretta, I.; Ardito, F.; Riccardi, L.; Nicoletti, A.; Ponziani, F.R.; Gasbarrini, A.; Pompili, M.; Pola, R. HepPar1-Positive Circulating Microparticles Are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection. Int. J. Mol. Sci. 2017, 18, 1043.

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