Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2014, 15(5), 7711-7730; doi:10.3390/ijms15057711
Review

Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

1,*  and 2
Received: 20 February 2014; in revised form: 30 April 2014 / Accepted: 30 April 2014 / Published: 5 May 2014
(This article belongs to the collection Molecular Mechanisms of Human Liver Diseases)
View Full-Text   |   Download PDF [1145 KB, uploaded 19 June 2014]
Abstract: Kupffer cells reside within the liver sinusoid and serve as gatekeepers. They produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as Toll-like receptors. Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupffer cells. In this paper, we review the importance of Kupffer cells in murine acute liver injuries and focus on the following two models: lipopolysaccharide (LPS)-induced liver injury, which is induced by priming with Propionibacterium acnes and subsequent challenge with LPS, and hypercoagulability-mediated acute liver failure such as that in concanavalin A (Con A)-induced hepatitis. Kupffer cells are required for LPS sensitization induced by P. acnes and are a major cellular source of interleukin-18, which induces acute liver injury following LPS challenge. Kupffer cells contribute to Con A-induced acute liver failure by initiating pathogenic, intrasinusoidal thrombosis in collaboration with sinusoidal endothelial cells. The mechanisms underlying these models may shed light on human liver injuries induced by various etiologies such as viral infection and/or abnormal metabolism.
Keywords: Propionibacterium acnes; lipopolysaccharide (LPS); Toll-like receptor (TLR); inflammasome; interleukin-18 (IL-18); Fas; concanavalin A (Con A); acetaminophen (APAP); tissue factor; procoagulant and anticoagulant pathways Propionibacterium acnes; lipopolysaccharide (LPS); Toll-like receptor (TLR); inflammasome; interleukin-18 (IL-18); Fas; concanavalin A (Con A); acetaminophen (APAP); tissue factor; procoagulant and anticoagulant pathways
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Tsutsui, H.; Nishiguchi, S. Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice. Int. J. Mol. Sci. 2014, 15, 7711-7730.

AMA Style

Tsutsui H, Nishiguchi S. Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice. International Journal of Molecular Sciences. 2014; 15(5):7711-7730.

Chicago/Turabian Style

Tsutsui, Hiroko; Nishiguchi, Shuhei. 2014. "Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice." Int. J. Mol. Sci. 15, no. 5: 7711-7730.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert