Next Article in Journal
The Role of Symbiotic Nitrogen Fixation in Sustainable Production of Biofuels
Next Article in Special Issue
Current Status in the Therapy of Liver Diseases
Previous Article in Journal
Symbiotic Activity of Pea (Pisum sativum) after Application of Nod Factors under Field Conditions
Previous Article in Special Issue
The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(5), 7352-7379; doi:10.3390/ijms15057352

Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
Received: 1 March 2014 / Revised: 28 March 2014 / Accepted: 10 April 2014 / Published: 29 April 2014
(This article belongs to the collection Molecular Mechanisms of Human Liver Diseases)
View Full-Text   |   Download PDF [3081 KB, 19 June 2014; original version 19 June 2014]   |  

Abstract

Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), in which most patients exhibit non-progressive, non-alcoholic fatty liver (NAFL) attributable to simple steatosis. Multiple hits, including genetic differences, fat accumulation, insulin resistance and intestinal microbiota changes, account for the progression of NASH. NAFLD is strongly associated with obesity, which induces adipokine secretion, endoplasmic reticulum (ER) and oxidative stress at the cellular level, which in turn induces hepatic steatosis, inflammation and fibrosis. Among these factors, gut microbiota are acknowledged as having an important role in initiating this multifactorial disease. Oxidative stress is considered to be a key contributor in the progression from NAFL to NASH. Macrophage infiltration is apparent in NAFL and NASH, while T-cell infiltration is apparent in NASH. Although several clinical trials have shown that antioxidative therapy with vitamin E can effectively control hepatitis pathology in the short term, the long-term effects remain obscure and have often proved to be ineffective in many other diseases. Several long-term antioxidant protocols have failed to reduce mortality. New treatment modalities that incorporate current understanding of NAFLD molecular pathogenesis must be considered.
Keywords: non-alcoholic fatty liver; non-alcoholic steatohepatitis; microbiome; oxidative stress non-alcoholic fatty liver; non-alcoholic steatohepatitis; microbiome; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Takaki, A.; Kawai, D.; Yamamoto, K. Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH). Int. J. Mol. Sci. 2014, 15, 7352-7379.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top