Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma
AbstractThe cAMP-regulated phosphoprotein 19 (ARPP-19) plays a key role in cell mitotic G2/M transition. Expression of ARPP-19 was increased in human hepatocellular carcinoma (HCC) compared to adjacent non-tumorous liver tissues in 36 paired liver samples, and the level of ARPP-19 in HCC tissues was positively correlated with the tumor size. To determine the interrelationship between ARPP-19 expression and HCC, we silenced ARPP-19 expression in the human hepatocarcinoma HepG2 and SMMC-7721 cells using lentivirus encoding ARPP-19 siRNA. HepG2 and SMMC-7721 cells with ARPP-19 knockdown displayed lowered cell growth rate, retarded colony formation and increased arrest at the G2/M phase transition. Silencing ARPP-19 in HCC cells resulted in decreased protein levels of phospho-(Ser) CDKs substrates and increased levels of inactivated cyclin division cycle 2 (Cdc2). Therefore, ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation. View Full-Text
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Song, H.; Pan, J.; Liu, Y.; Wen, H.; Wang, L.; Cui, J.; Liu, Y.; Hu, B.; Yao, Z.; Ji, G. Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma. Int. J. Mol. Sci. 2015, 16, 178-192.
Song H, Pan J, Liu Y, Wen H, Wang L, Cui J, Liu Y, Hu B, Yao Z, Ji G. Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2015; 16(1):178-192.Chicago/Turabian Style
Song, Haiyan; Pan, Jielu; Liu, Yang; Wen, Hongzhu; Wang, Lei; Cui, Jiefeng; Liu, Yinkun; Hu, Bing; Yao, Zemin; Ji, Guang. 2015. "Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma." Int. J. Mol. Sci. 16, no. 1: 178-192.