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Int. J. Mol. Sci. 2015, 16(1), 178-192; doi:10.3390/ijms16010178

Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma

1
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
2
Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200032, China
3
Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
4
Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 7 October 2014 / Accepted: 15 December 2014 / Published: 24 December 2014
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
View Full-Text   |   Download PDF [2239 KB, uploaded 24 December 2014]   |  

Abstract

The cAMP-regulated phosphoprotein 19 (ARPP-19) plays a key role in cell mitotic G2/M transition. Expression of ARPP-19 was increased in human hepatocellular carcinoma (HCC) compared to adjacent non-tumorous liver tissues in 36 paired liver samples, and the level of ARPP-19 in HCC tissues was positively correlated with the tumor size. To determine the interrelationship between ARPP-19 expression and HCC, we silenced ARPP-19 expression in the human hepatocarcinoma HepG2 and SMMC-7721 cells using lentivirus encoding ARPP-19 siRNA. HepG2 and SMMC-7721 cells with ARPP-19 knockdown displayed lowered cell growth rate, retarded colony formation and increased arrest at the G2/M phase transition. Silencing ARPP-19 in HCC cells resulted in decreased protein levels of phospho-(Ser) CDKs substrates and increased levels of inactivated cyclin division cycle 2 (Cdc2). Therefore, ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation. View Full-Text
Keywords: hepatocellular carcinoma; ARPP-19; cell proliferation; cell cycle hepatocellular carcinoma; ARPP-19; cell proliferation; cell cycle
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Song, H.; Pan, J.; Liu, Y.; Wen, H.; Wang, L.; Cui, J.; Liu, Y.; Hu, B.; Yao, Z.; Ji, G. Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma. Int. J. Mol. Sci. 2015, 16, 178-192.

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