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Int. J. Mol. Sci. 2016, 17(4), 500; doi:10.3390/ijms17040500

Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma

1
Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain
2
Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain
3
Department of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain
4
Department of Physiology, Faculty of Medicine, University of the La Laguna, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain
5
Department of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain
6
Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, Santa Cruz de Tenerife 38320, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 10 March 2016 / Revised: 29 March 2016 / Accepted: 30 March 2016 / Published: 5 April 2016
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
View Full-Text   |   Download PDF [595 KB, uploaded 5 April 2016]   |  

Abstract

Previous studies have found higher levels of serum malondialdehyde (MDA) in hepatocellular carcinoma (HCC) patients compared to healthy controls and higher MDA concentrations in tumoral tissue of HCC patients than in non-tumoral tissue. However, the association between pre-transplant serum levels of MDA and survival in HCC patients after liver transplantation (LT) has not been described, and the aim of the present study was to determine whether such an association exists. In this observational study we measured serum MDA levels in 127 patients before LT. We found higher pre-LT serum MDA levels in 15 non-surviving than in 112 surviving patients one year after LT (p = 0.02). Exact binary logistic regression analysis revealed that pre-LT serum levels of MDA over 3.37 nmol/mL were associated with mortality after one year of LT (Odds ratio = 5.38; 95% confidence interval (CI) = from 1.580 to infinite; p = 0.007) adjusting for age of the deceased donor. The main finding of our study was that there is an association between serum MDA levels before LT for HCC and 1-year survival after LT. View Full-Text
Keywords: MDA; hepatocellular carcinoma; liver transplantation; mortality; outcome MDA; hepatocellular carcinoma; liver transplantation; mortality; outcome
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Lorente, L.; Rodriguez, S.T.; Sanz, P.; Abreu-González, P.; Díaz, D.; Moreno, A.M.; Borja, E.; Martín, M.M.; Jiménez, A.; Barrera, M.A. Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma. Int. J. Mol. Sci. 2016, 17, 500.

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