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Int. J. Mol. Sci. 2014, 15(11), 20656-20667; doi:10.3390/ijms151120656

Potential Roles of BMP9 in Liver Fibrosis

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
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Author to whom correspondence should be addressed.
Received: 5 September 2014 / Revised: 13 October 2014 / Accepted: 4 November 2014 / Published: 11 November 2014
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
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Abstract

Liver fibrosis is a common phenomenon that is associated with several pathologies and is characterized by excessive extracellular matrix deposition that leads to progressive liver dysfunction. Bone morphogenetic protein 9 (BMP9) is the most recently discovered member of the BMP family. BMP9 bound with high affinity to activin receptor-like kinase 1 (ALK1) and endoglin in non-parenchymal liver cells. In addition, BMP9 activated Smad1/Smad5/Smad8 and induced the expression of the target genes inhibitor of differentiation 1 (Id1), hepcidin, Snail and the co-receptor endoglin in liver cells. Although the role of BMP9 in liver fibrosis is currently poorly understood, the presence of BMP9-activated proteins and its target genes have been reported to be associated with liver fibrosis development. This review summarizes the indirect connection between BMP9 and liver fibrosis, with a focus on the BMP9 signaling pathway members ALK1, endoglin, Id1, hepcidin and Snail. The observations on the role of BMP9 in regulating liver fibrosis may help in understanding the pathology mechanisms of liver disease. Furthermore, BMP9 could be served as a potent biomarker and the target of potential therapeutic drugs to treat hepatocytes fibrosis. View Full-Text
Keywords: bone morphogenetic protein 9 (BMP9); activin receptor-like kinase 1 (ALK1); endoglin; inhibitor of differentiation 1 (Id1); hepcidin; Snail; liver fibrosis bone morphogenetic protein 9 (BMP9); activin receptor-like kinase 1 (ALK1); endoglin; inhibitor of differentiation 1 (Id1); hepcidin; Snail; liver fibrosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bi, J.; Ge, S. Potential Roles of BMP9 in Liver Fibrosis. Int. J. Mol. Sci. 2014, 15, 20656-20667.

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