Two new polyketides: 2
Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-
2H-chromen-5(
6H)-one (
1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (
2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (
3), oleiferinone (
4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (
5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (
6
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Two new polyketides: 2
Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-
2H-chromen-5(
6H)-one (
1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (
2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (
3), oleiferinone (
4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (
5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (
6), proctorione C (
7), surinone C (
8), 5-hydroxy- 7,8,4'-trimethoxyflavone (
9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (
10), 5-hydroxy- 7,3',4'-trimethoxyflavone (
11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (
12) and cepharanone B (
13) were isolated from the whole plant of
Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds
2,
3,
5 and
8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds
5 and
8 sharply suppressed HUVEC tube formation.
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