Special Issue "Dendrimers - from Synthesis to Applications"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (30 August 2009)

Special Issue Editor

Guest Editor
Prof. Dr. Afang Zhang
Wolfgang-Pauli-Strasse 10, HCI G525, Institute of Polymers, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland
Website: https://www.bi.id.ethz.ch/postel/arbeitsDetailsPre.do?teilnehmernummer=39326
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Published Papers

Click here to see a list of 6 papers that have been published in this special issue.

Special Issue Information

Submission

All papers should be submitted to molecules@mdpi.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.
Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed monthly journal published by Molecular Diversity Preservation International.
Please visit the Instructions for Authors page before submitting a paper. Open Access publication fees are 800 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections.).

Keywords

Biomedical applications, chiral dendrimer, dendrimer assembly, dendrimer block copolymers, dendrimer chirality, dendrimer conjugates, dendrimer-like star polymers, dendrimer MRI contrast agents, dendrimer nanoparticles, dendrimer nonreactors, dendrimer nano-templates, dendrimer synthesis, dendron, dendronized polymers, drug delivery, hyperbranched polymers, organocatalysis, peptide dendrimer, stimuli-responsive dendrimers, supramolecular dendrimers

Planned Papers

Manuscript ID: molecules-dendrimers-20081118-us-Rinaldi
Type of Paper: Review
Title: Solution NMR Studies of Dendrimers (Outline)
Authors: Minghui Chai1,* and Peter L. Rinaldi2,*
Affiliations: 1Department of Chemistry, Central Michigan University, Mt. Pleasant, MI 48858; E-mail: Minghui.chai@cmich.edu
2Department of Chemistry, The University of Akron, Akron, OH 44325; E-mail: PeterRinaldi@uakron.edu
Abstract: NMR spectroscopy has been a powerful tool for structural characterization and property study of molecules, especially for biopolymers. Dendrimers are unique type of synthetic macromolecules with a cascade hyper-branched structure and spherical shape if perfectly generated. Classic 1D 1H and 13C NMR techniques have been heavily utilized for dendrimer structural verification after the synthesis. This review focuses on the applications of special NMR techniques such as NMR relaxation time and diffusion measurements, multinuclear NMR spectroscopy, as well as multidimensional homo- and hetero-nuclear correlation spectroscopy for studying the structure, property and interactions of dendrimers.
Keywords: Dendrimer, Dendrimer assembly, NMR, Multinuclear NMR, Multidimensional NMR

Manuscript ID: molecules-dendrimers-20090101-pl-Klajnert
Type of Paper: Article
Title: Influence of dendrimer chemistry on its antiprion activity
Authors: Barbara Klajnert 1,*, Ling Peng 2, Rafael Gomez 3,5,F. Javier de la Mata 3,5, M. Angeles Muñoz-Fernandez 4,5, Maria Bryszewska 1
Affiliations: 1 Department of General Biophysics, University of Lodz, Poland
2 Departement de chimie CNRS, Marseille, France
3 Departamento de Química Inorgánica, Universidad de Alcalá, Spain
4 Hospital General Universitario Gregorio Marañón, Madrid , Spain
5 CIBER-BBN
* Author to whom correspondence should be addressed; E-mail: aklajn@biol.uni.lodz.pl
Abstract: Prion disorders are fatal neurodegenerative diseases resulting in the formation of fibrils – amyloid-like structures.It has been shown that dendrimers possess antiprion activity. We checked different dendrimers in terms of generation (size) and chemical composition: carbosilane dendrimers with tertiary and quaternary amino groups on the surface and PAMAM dendrimers with the same functionalities. It turned out that dendrimer interior and end groups influenced fibril formation. For PAMAM dendrimers at low concentrations we observed the acceleration of fibril formation, whereas high concentrations completely inhibited the process. In the case of carbosilane dendrimers no acceleration was observed, but the inhibitory trend occurred for higher concentrations.

Figure 1. Kinetics of fibril formation in the presence of dendrimers that inhibited the process, and upon adding dendrimers that enhanced the fibril formation.

abstract graphic

Last update: 22 September 2009

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