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Antiangiogenic Polyketides from Peperomia dindygulensis Miq.
Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Pharmacy, Shanghai Institute of Health Sciences, Shanghai 201318, China
Department of Pharmacy, Health School Attached to Shanghai Jiao Tong University School of Medicine, Shanghai 201318, China
Department of Pharmaceutical Sciences, School of Chemistry, Shanxi University, Taiyuan 030006, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 February 2012; in revised form: 5 April 2012 / Accepted: 6 April 2012 / Published: 13 April 2012
Abstract: Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
Keywords: Peperomia dindygulensis Miq.; polyketides; antiangiogenic activity
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Wang, Q.-W.; Yu, D.-H.; Lin, M.-G.; Zhao, M.; Zhu, W.-J.; Lu, Q.; Li, G.-X.; Wang, C.; Yang, Y.-F.; Qin, X.-M.; Fang, C.; Chen, H.-Z.; Yang, G.-H. Antiangiogenic Polyketides from Peperomia dindygulensis Miq.. Molecules 2012, 17, 4474-4483.
Wang Q-W, Yu D-H, Lin M-G, Zhao M, Zhu W-J, Lu Q, Li G-X, Wang C, Yang Y-F, Qin X-M, Fang C, Chen H-Z, Yang G-H. Antiangiogenic Polyketides from Peperomia dindygulensis Miq.. Molecules. 2012; 17(4):4474-4483.
Wang, Qi-Wei; Yu, De-Hong; Lin, Meng-Gan; Zhao, Mei; Zhu, Wen-Jun; Lu, Qin; Li, Gui-Xiu; Wang, Chao; Yang, Yi-Fang; Qin, Xue-Mei; Fang, Chao; Chen, Hong-Zhuan; Yang, Guo-Hong. 2012. "Antiangiogenic Polyketides from Peperomia dindygulensis Miq.." Molecules 17, no. 4: 4474-4483.