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Molecules 2012, 17(4), 4474-4483; doi:10.3390/molecules17044474

Antiangiogenic Polyketides from Peperomia dindygulensis Miq.

1,†, 2,†, 1,†, 3,4, 1, 2, 5, 2, 1, 5, 2,* , 2,*  and 1,*
1 Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China 2 Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 3 Department of Pharmacy, Shanghai Institute of Health Sciences, Shanghai 201318, China 4 Department of Pharmacy, Health School Attached to Shanghai Jiao Tong University School of Medicine, Shanghai 201318, China 5 Department of Pharmaceutical Sciences, School of Chemistry, Shanxi University, Taiyuan 030006, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 February 2012 / Revised: 5 April 2012 / Accepted: 6 April 2012 / Published: 13 April 2012
(This article belongs to the Section Natural Products)
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Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
Keywords: Peperomia dindygulensis Miq.; polyketides; antiangiogenic activity Peperomia dindygulensis Miq.; polyketides; antiangiogenic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, Q.-W.; Yu, D.-H.; Lin, M.-G.; Zhao, M.; Zhu, W.-J.; Lu, Q.; Li, G.-X.; Wang, C.; Yang, Y.-F.; Qin, X.-M.; Fang, C.; Chen, H.-Z.; Yang, G.-H. Antiangiogenic Polyketides from Peperomia dindygulensis Miq.. Molecules 2012, 17, 4474-4483.

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