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Molecules 2012, 17(4), 4474-4483; doi:10.3390/molecules17044474
Article

Antiangiogenic Polyketides from Peperomia dindygulensis Miq.

1,†, 2,†, 1,†, 3,4, 1, 2, 5, 2, 1, 5, 2,* , 2,*  and 1,*
Received: 17 February 2012 / Revised: 5 April 2012 / Accepted: 6 April 2012 / Published: 13 April 2012
(This article belongs to the Section Metabolites)
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Abstract

Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
Keywords: Peperomia dindygulensis Miq.; polyketides; antiangiogenic activity Peperomia dindygulensis Miq.; polyketides; antiangiogenic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, Q.-W.; Yu, D.-H.; Lin, M.-G.; Zhao, M.; Zhu, W.-J.; Lu, Q.; Li, G.-X.; Wang, C.; Yang, Y.-F.; Qin, X.-M.; Fang, C.; Chen, H.-Z.; Yang, G.-H. Antiangiogenic Polyketides from Peperomia dindygulensis Miq.. Molecules 2012, 17, 4474-4483.

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