Next Article in Journal
Anti-Tumour Promoting Activity and Antioxidant Properties of Girinimbine Isolated from the Stem Bark of Murraya koenigii S.
Previous Article in Journal
An Improved Synthesis of Pentacene: Rapid Access to a Benchmark Organic Semiconductor
Molecules 2012, 17(4), 4634-4650; doi:10.3390/molecules17044634

Synthesis and Antibacterial Evaluation of New N-acylhydrazone Derivatives from Dehydroabietic Acid

* , , , ,  and
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
* Author to whom correspondence should be addressed.
Received: 26 March 2012 / Revised: 1 April 2012 / Accepted: 5 April 2012 / Published: 20 April 2012
View Full-Text   |   Download PDF [313 KB, uploaded 18 June 2014]   |   Browse Figures


A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR, ESI-MS, elemental analysis and single crystal X-ray diffraction. From the crystal structure of compound 4l, the C=N double bonds of these N-acylhydrazones showed (E)-configuration, while the NMR data of compounds 4aq indicated the existence of two rotamers for each compound in solution. The target compounds were evaluated for their antibacterial activities against four microbial strains. The result suggested that several compounds exhibited pronounced antibacterial activities. Particularly, compound 4p exhibited good antibacterial activity against Staphylococcus aureus and Bacillus subtilis comparable to positive control. The possible antibacterial metabolism and the strategy for further optimization of this compound were also discussed.
Keywords: N-acylhydrazone; dehydroabietic acid; synthesis; antibacterial activity N-acylhydrazone; dehydroabietic acid; synthesis; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Gu, W.; Wu, R.; Qi, S.; Gu, C.; Si, F.; Chen, Z. Synthesis and Antibacterial Evaluation of New N-acylhydrazone Derivatives from Dehydroabietic Acid. Molecules 2012, 17, 4634-4650.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert