Next Article in Journal
Systematic Evaluation of Structure-Activity Relationships of the Riminophenazine Class and Discovery of a C2 Pyridylamino Series for the Treatment of Multidrug-Resistant Tuberculosis
Next Article in Special Issue
Microwave Synthesis Under Solvent-Free Conditions and Spectral Studies of Some Mesoporphyrinic Complexes
Previous Article in Journal
Gene Cloning, Expression and Activity Analysis of Manganese Superoxide Dismutase from Two Strains of Gracilaria lemaneiformis (Gracilariaceae, Rhodophyta) under Heat Stress
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(4), 4533-4544; doi:10.3390/molecules17044533

Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3

1
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China
2
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China
*
Authors to whom correspondence should be addressed.
Received: 7 March 2012 / Revised: 31 March 2012 / Accepted: 6 April 2012 / Published: 16 April 2012
(This article belongs to the Special Issue Solvent-Free Synthesis)
View Full-Text   |   Download PDF [232 KB, uploaded 18 June 2014]   |  

Abstract

Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations. View Full-Text
Keywords: solvent-free; chlorination; phosphorous oxychloride (POCl3) solvent-free; chlorination; phosphorous oxychloride (POCl3)
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, H.; Wen, K.; Wang, L.; Xiang, Y.; Xu, X.; Shen, Y.; Sun, Z. Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3. Molecules 2012, 17, 4533-4544.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top