Molecules 2012, 17(4), 4533-4544; doi:10.3390/molecules17044533
Article

Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3

1 School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China 2 College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China
* Authors to whom correspondence should be addressed.
Received: 7 March 2012; in revised form: 31 March 2012 / Accepted: 6 April 2012 / Published: 16 April 2012
(This article belongs to the Special Issue Solvent-Free Synthesis)
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Abstract: Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
Keywords: solvent-free; chlorination; phosphorous oxychloride (POCl3)

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MDPI and ACS Style

Wang, H.; Wen, K.; Wang, L.; Xiang, Y.; Xu, X.; Shen, Y.; Sun, Z. Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3. Molecules 2012, 17, 4533-4544.

AMA Style

Wang H, Wen K, Wang L, Xiang Y, Xu X, Shen Y, Sun Z. Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3. Molecules. 2012; 17(4):4533-4544.

Chicago/Turabian Style

Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua. 2012. "Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3." Molecules 17, no. 4: 4533-4544.

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