Molecules 2012, 17(4), 4508-4521; doi:10.3390/molecules17044508
Article

The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

1 Department of Chemistry, “Sapienza” University of Rome, P.le A. Moro 5, I-00185 Roma, Italy 2 Department of Mechanical and Industrial Engineering and CISDiC, University of Studies “Roma Tre”, via della Vasca Navale 79, I-00146 Roma, Italy
* Author to whom correspondence should be addressed.
Received: 20 February 2012; in revised form: 5 April 2012 / Accepted: 9 April 2012 / Published: 16 April 2012
(This article belongs to the Section Organic Synthesis)
PDF Full-text Download PDF Full-Text [267 KB, uploaded 16 April 2012 09:08 CEST]
Abstract: The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
Keywords: indazoles; pyrrole; thiophene; Suzuki cross-coupling; heterobiaryl compounds

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Migliorini, A.; Oliviero, C.; Gasperi, T.; Loreto, M.A. The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles. Molecules 2012, 17, 4508-4521.

AMA Style

Migliorini A, Oliviero C, Gasperi T, Loreto MA. The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles. Molecules. 2012; 17(4):4508-4521.

Chicago/Turabian Style

Migliorini, Antonella; Oliviero, Chiara; Gasperi, Tecla; Loreto, Maria Antonietta. 2012. "The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles." Molecules 17, no. 4: 4508-4521.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert