Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(4), 4508-4521; doi:10.3390/molecules17044508
Article

The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

1
, 1
, 2
 and 1,*
Received: 20 February 2012; in revised form: 5 April 2012 / Accepted: 9 April 2012 / Published: 16 April 2012
(This article belongs to the Section Organic Synthesis)
Download PDF [267 KB, uploaded 18 June 2014]
Abstract: The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
Keywords: indazoles; pyrrole; thiophene; Suzuki cross-coupling; heterobiaryl compounds indazoles; pyrrole; thiophene; Suzuki cross-coupling; heterobiaryl compounds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Migliorini, A.; Oliviero, C.; Gasperi, T.; Loreto, M.A. The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles. Molecules 2012, 17, 4508-4521.

AMA Style

Migliorini A, Oliviero C, Gasperi T, Loreto MA. The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles. Molecules. 2012; 17(4):4508-4521.

Chicago/Turabian Style

Migliorini, Antonella; Oliviero, Chiara; Gasperi, Tecla; Loreto, Maria Antonietta. 2012. "The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles." Molecules 17, no. 4: 4508-4521.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert