Special Issue "Terpenoids"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 November 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Alejandro Fernandez Barrero
Department of Organic Chemistry and Institute of Biotechnology, Faculty of Sciences, University of Granada, Avda de Fuentenueva s/n,18071 Granada, Spain
E-Mail: afbarre@ugr.es
Interests: natural products chemistry; synthesis of bioactive terpenoids; radical strategies; biomimetic cyclizations; new quirons as starting materials; terpenoids from fungi

Special Issue Information

Dear Colleagues,

Terpenoids, including more than 35.000 well defined molecules, probably constitutes the natural products family with the greater structural diversity. Numerous of these compounds possess well known applications as drugs, cosmetics, perfumes, flavours, insecticides, herbicides, phyto-hormones and many others. In recent years a number of advances in terpenoid research have led for example to the discovery of a second biosynthetic pathway, namely methyl-erythritol phosphate pathway (MEP), usually present in bacteria and plants. The knowledge of the structure of both, enzymes and genes involved in this pathway and the detailed mechanism of the specific steps are opening the possibility to develop new selective and efficient molecules with bioactivities against those pathogen micro-organisms responsible of the resistant strains from tuberculosis and malaria. Furthermore we have acquired better understanding of the structure and way of working of the key-enzymes, prenyltransferases and terpenecyclases, which are the principal motive of the uncommon molecular diversity in terpenoids. All this is provoking, among other things a develop of new research lines in order to optimize the biotechnological production of bioactive terpenes through genetic engineering from plants and microorganisms.

Moreover advances in Organic Synthesis, including new biomimetic strategies and the use of natural quirons, are reaching an important role in the development of more efficient syntheses easily scalable to industrial levels. Thus, is remarkable the appearance at antitumor medicament worldwide market of diverse diterpene taxol derivatives thanks to the sustainable farming of Taxus baccata, plant used as natural source for the terpenic backbone in combination with a semisynthetic process.

This special issue attempts to be a meeting point and a discussion forum for the interchange of experiences in terpenoid chemistry. Contributions about all the different steps involved in this field of research: extraction processes; isolation procedures; structural elucidation; direct identification from extracts by chromatographic or spectroscopic techniques; derreplication by HPLC combined with Mass Spectrometry or NMR; biotransformations; partial synthesis or total synthesis will be well received.

Prof. Dr. Alejandro Fernandez Barrero
Guest Editor

Keywords

  • isoprenoids
  • monoterpenes
  • sesquiterpenes
  • diterpenes
  • sesterterpenes
  • triterpenes
  • carotenes
  • meroterpenes
  • structural elucidation
  • terpenecyclases
  • biosynthesis
  • biotransformation
  • biotechnology
  • total synthesis
  • bioactivity
  • allelophaty
  • pesticides
  • drugs

Published Papers (17 papers)

by , , , , , , , , , ,  and
Molecules 2012, 17(9), 10550-10573; doi:10.3390/molecules170910550
Received: 9 August 2012; in revised form: 20 August 2012 / Accepted: 28 August 2012 / Published: 5 September 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (275 KB)
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by , , , , ,  and
Molecules 2012, 17(4), 4684-4702; doi:10.3390/molecules17044684
Received: 26 March 2012; in revised form: 11 April 2012 / Accepted: 12 April 2012 / Published: 20 April 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (355 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Molecules 2012, 17(4), 3866-3889; doi:10.3390/molecules17043866
Received: 12 December 2011; in revised form: 18 March 2012 / Accepted: 22 March 2012 / Published: 30 March 2012
Show/Hide Abstract | Cited by 14 | PDF Full-text (289 KB) | HTML Full-text | XML Full-text

by  and
Molecules 2012, 17(3), 3524-3538; doi:10.3390/molecules17033524
Received: 7 December 2011; in revised form: 12 March 2012 / Accepted: 16 March 2012 / Published: 19 March 2012
Show/Hide Abstract | Cited by 11 | PDF Full-text (646 KB)

by , , , , ,  and
Molecules 2012, 17(3), 2683-2703; doi:10.3390/molecules17032683
Received: 16 January 2012; in revised form: 22 February 2012 / Accepted: 28 February 2012 / Published: 5 March 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (321 KB)

by , ,  and
Molecules 2012, 17(3), 2542-2566; doi:10.3390/molecules17032542
Received: 20 December 2011; in revised form: 27 February 2012 / Accepted: 28 February 2012 / Published: 2 March 2012
Show/Hide Abstract | Cited by 14 | PDF Full-text (248 KB)
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by , ,  and
Molecules 2012, 17(2), 2259-2270; doi:10.3390/molecules17022259
Received: 20 December 2011; in revised form: 16 February 2012 / Accepted: 20 February 2012 / Published: 22 February 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (503 KB) | Correction | Supplementary Files

by , ,  and
Molecules 2012, 17(2), 1698-1715; doi:10.3390/molecules17021698
Received: 23 November 2011; in revised form: 26 January 2012 / Accepted: 6 February 2012 / Published: 9 February 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (350 KB) | Supplementary Files

by , , ,  and
Molecules 2012, 17(2), 1744-1750; doi:10.3390/molecules17021744
Received: 30 November 2011; in revised form: 19 January 2012 / Accepted: 3 February 2012 / Published: 9 February 2012
Show/Hide Abstract | PDF Full-text (187 KB)
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by , , ,  and
Molecules 2012, 17(2), 1448-1467; doi:10.3390/molecules17021448
Received: 25 November 2011; in revised form: 31 January 2012 / Accepted: 31 January 2012 / Published: 6 February 2012
Show/Hide Abstract | Cited by 9 | PDF Full-text (569 KB)
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by , ,  and
Molecules 2011, 16(12), 10541-10555; doi:10.3390/molecules161210541
Received: 4 November 2011; in revised form: 5 December 2011 / Accepted: 12 December 2011 / Published: 19 December 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (235 KB)

by , ,  and
Molecules 2011, 16(12), 10604-10618; doi:10.3390/molecules161210604
Received: 13 November 2011; in revised form: 2 December 2011 / Accepted: 12 December 2011 / Published: 19 December 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (283 KB)

by , , , ,  and
Molecules 2011, 16(12), 10645-10652; doi:10.3390/molecules161210645
Received: 22 November 2011; in revised form: 9 December 2011 / Accepted: 16 December 2011 / Published: 19 December 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (262 KB)

by  and
Molecules 2011, 16(12), 10471-10478; doi:10.3390/molecules161210471
Received: 22 November 2011; in revised form: 5 December 2011 / Accepted: 12 December 2011 / Published: 16 December 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (207 KB)
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by , ,  and
Molecules 2011, 16(10), 8402-8409; doi:10.3390/molecules16108402
Received: 26 August 2011; in revised form: 28 September 2011 / Accepted: 29 September 2011 / Published: 3 October 2011
Show/Hide Abstract | Cited by 6 | PDF Full-text (464 KB)
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by , , , ,  and
Molecules 2011, 16(9), 8119-8129; doi:10.3390/molecules16098119
Received: 25 July 2011; in revised form: 12 September 2011 / Accepted: 14 September 2011 / Published: 21 September 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (392 KB)

by , ,  and
Molecules 2011, 16(9), 8053-8061; doi:10.3390/molecules16098053
Received: 31 August 2011; in revised form: 4 September 2011 / Accepted: 14 September 2011 / Published: 19 September 2011
Show/Hide Abstract | Cited by 4 | PDF Full-text (436 KB)

Last update: 4 March 2014

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