Special Issue "Solvent-Free Synthesis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 April 2012)
Dr. Cynthia Kellen-Yuen
Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA
Interests: microwave assisted organic synthesis; greener synthetic approaches to biologically active heterocycles
The phrase “solvent-free synthesis” conjures up a wide variety of images and ideas amongst the chemistry community. Solvent-free could refer to anything from a mixture of reagents combined without the addition of added solvent—i.e. simply running a reaction “neat”, to the increasingly broad area of chemistry often referred to as solid-state synthesis. This synthetic approach is of particular interest in the modern world since it explores new ways to control the transformation of molecules without the necessity of employing large volumes of solvents, which often add to the cost and environmental impact of the reaction itself. Additional benefits of this approach are often seen in higher product yields and lower energy costs associated with both the running of the reactions and the subsequent clean-up of product. Overall, this makes many of the reactions performed under solvent-free conditions also appeal to those of us interested in the field of Green Chemistry.
This Special Issue on Solvent-Free Synthesis will offer a forum to present papers focused on the synthesis of molecules using a variety of novel and environmentally-friendly strategies. I hope that this issue will reflect the innovation and diversity of this growing field of chemistry.
Dr. Cynthia Kellen-Yuen
- solvent free
- solid state
- green chemistry
- heterogeneous catalysis
- mesoporous catalysis
Article: Solvent-Free Synthesis, DNA-Topoisomerase II Activity and Molecular Docking Study of New Asymmetrically N,N'-Substituted Ureas
Molecules 2012, 17(11), 12882-12894; doi:10.3390/molecules171112882
Received: 28 August 2012; in revised form: 26 September 2012 / Accepted: 26 October 2012 / Published: 1 November 2012| Download PDF Full-text (325 KB) | Download XML Full-text
Communication: Solvent-Free Synthesis of Modified Pectin Compounds Promoted by Microwave Irradiation
Molecules 2012, 17(10), 12234-12242; doi:10.3390/molecules171012234
Received: 14 September 2012; in revised form: 1 October 2012 / Accepted: 16 October 2012 / Published: 18 October 2012| Download PDF Full-text (268 KB) | Download XML Full-text | Supplementary Files
Molecules 2012, 17(10), 11469-11483; doi:10.3390/molecules171011469
Received: 24 August 2012; in revised form: 18 September 2012 / Accepted: 20 September 2012 / Published: 27 September 2012| Download PDF Full-text (271 KB)
Article: Microwave Synthesis Under Solvent-Free Conditions and Spectral Studies of Some Mesoporphyrinic Complexes
Molecules 2012, 17(5), 5592-5603; doi:10.3390/molecules17055592
Received: 20 March 2012; in revised form: 4 May 2012 / Accepted: 7 May 2012 / Published: 10 May 2012| Download PDF Full-text (220 KB)
Article: Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3
Molecules 2012, 17(4), 4533-4544; doi:10.3390/molecules17044533
Received: 7 March 2012; in revised form: 31 March 2012 / Accepted: 6 April 2012 / Published: 16 April 2012| Download PDF Full-text (232 KB) | Download XML Full-text | Supplementary Files
Last update: 4 March 2014