Special Issue "Solvent-Free Synthesis"

Guest Editor
Dr. Cynthia Kellen-Yuen
Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA
Website: http://www.csus.edu/indiv/k/kellen-yuenc/
E-Mail: ckyuen@csus.edu
Interests: microwave assisted organic synthesis; greener synthetic approaches to biologically active heterocycles

Dear Colleagues,

The phrase “solvent-free synthesis” conjures up a wide variety of images and ideas amongst the chemistry community.  Solvent-free could refer to anything from a mixture of reagents combined without the addition of added solvent—i.e. simply running a reaction “neat”, to the increasingly broad area of chemistry often referred to as solid-state synthesis.  This synthetic approach is of particular interest in the modern world since it explores new ways to control the transformation of molecules without the necessity of employing large volumes of solvents, which often add to the cost and environmental impact of the reaction itself.  Additional benefits of this approach are often seen in higher product yields and lower energy costs associated with both the running of the reactions and the subsequent clean-up of product. Overall, this makes many of the reactions performed under solvent-free conditions also appeal to those of us interested in the field of Green Chemistry.

This Special Issue on Solvent-Free Synthesis will offer a forum to present papers focused on the synthesis of molecules using a variety of novel and environmentally-friendly strategies.  I hope that this issue will reflect the innovation and diversity of this growing field of chemistry.

Dr. Cynthia Kellen-Yuen
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs).

• solvent free
• solid state
• zeolite
• green chemistry
• heterogeneous catalysis
• materials
• mesoporous catalysis

Type of Paper: Article
Title: Silica Gel-mediated Organic Reactions which Proceed under Solvent-free Conditions
Author: Junji Inanaga
Affiliation: Institute for Fundamental Research of Organic Chemistry, Kyushu University, Hakozaki, Fukuoka 812-8581, Japan
Abstract: Novel aspects of silica gel as a reaction medium will be disclosed for some useful organic transformations using no organic solvent. They are (1) selective allylation of aldehydes with equivalent of allyltin, (2) one-pot olefination of aldehydes with organic halides with the aid of a phosphine and a base, (3) Horner-Wadsworth-Emmons reaction of aldehydes at ambient temperature, and (4) Friedel-Crafts nitration of arenes using aqueous nitric acid.

Type of Paper: Article
Title: Nanoshell Carbon-supported Cobalt Catalyst for the Aerobic Oxidation of Alcohols in the Presence of Benzaldehyde: An Efficient, Solvent Free Protocol
Authors: Yongbo Kuang, Yuta Nabae, Teruaki Hayakawa and Masa-aki Kakimoto
Affiliation: Department of Organic and Polymeric Materials, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8552, Japan; E-Mail: mkakimot@o.cc.titech.ac.jp (M.K.); kuang.y.ac@m.titech.ac.jp (Y.K.)
Abstract: A versatile, solvent free aerobic alcohol oxidation system has been established in the presence of benzaldehyde based on a heterogenous cobalt catalyst, which was prepared through the pyrolysis of Co(II) phthalocyanine and phenol resin. The established system features equal efficiency toward both benzylic alcohols and aliphatic alcohols.