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• Ning, M
• Yang, G
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Molecules 2012, 17(4), 4672-4683; doi:10.3390/molecules17044672

Article

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Bendong Chen ^1,2 , Mingliang Ning ³  and Guangshun Yang ^1,*

¹ Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China ² Department of Hepatobiliary Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China ³ Department of Oncological Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China

* Author to whom correspondence should be addressed.

Received: 8 March 2012; in revised form: 27 March 2012 / Accepted: 5 April 2012 / Published: 20 April 2012

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Abstract: The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.

Keywords: hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine

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