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Molecules 2012, 17(4), 4672-4683; doi:10.3390/molecules17044672
Article

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

1,2, 3 and 1,*
Received: 8 March 2012; in revised form: 27 March 2012 / Accepted: 5 April 2012 / Published: 20 April 2012
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Abstract: The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
Keywords: hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, B.; Ning, M.; Yang, G. Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats. Molecules 2012, 17, 4672-4683.

AMA Style

Chen B, Ning M, Yang G. Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats. Molecules. 2012; 17(4):4672-4683.

Chicago/Turabian Style

Chen, Bendong; Ning, Mingliang; Yang, Guangshun. 2012. "Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats." Molecules 17, no. 4: 4672-4683.


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