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Molecules 2012, 17(4), 4672-4683; doi:10.3390/molecules17044672

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

1
Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China
2
Department of Hepatobiliary Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
3
Department of Oncological Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
*
Author to whom correspondence should be addressed.
Received: 8 March 2012 / Revised: 27 March 2012 / Accepted: 5 April 2012 / Published: 20 April 2012
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Abstract

The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
Keywords: hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, B.; Ning, M.; Yang, G. Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats. Molecules 2012, 17, 4672-4683.

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