Topic Editors

Department of Pharmaceutical Sciences, Graduate School of Medicine, Pharmaceutical Research and Technology Institute, Kindai University, Higashiosaka, Japan
Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan

Purification of Plant Extracts

Abstract submission deadline
closed (30 April 2024)
Manuscript submission deadline
30 June 2024
Viewed by
3040

Topic Information

Dear Colleagues,

Separation is one of the chemical reactions that occurs between compounds and solid phases and/or mobile phases. Their combinations are infinite, and every compound should be separated into a single pure form. We are happy to invite colleagues to submit papers outlining examples of compounds and their separation methods.

In addition to this, plants are widely recognized as one of the biggest sources of active compounds used in medicine and functional foods. However, there are various plants yet to be investigated for new novel compounds.

Thus, this Topic is focused on the purification of bioactive natural products from plant resources as well as the various chromatography approaches to analyse these products, including GC and HPLC. Papers on the isolation and structural determination of novel compounds of plant origin, as well as on methods used for their analysis, are welcome for submission.

Dr. Kazuya Murata
Prof. Dr. Toshio Morikawa
Topic Editors

Keywords

  • purification
  • plant extracts
  • GC
  • HPLC
  • separation

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Foods
foods
5.2 7.4 2012 13.1 Days CHF 2900 Submit
Molecules
molecules
4.6 7.4 1996 14.6 Days CHF 2700 Submit
Plants
plants
4.5 6.5 2012 15.3 Days CHF 2700 Submit
Processes
processes
3.5 5.1 2013 13.7 Days CHF 2400 Submit
Separations
separations
2.6 3.0 2014 13.6 Days CHF 2600 Submit

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Published Papers (2 papers)

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16 pages, 3519 KiB  
Article
Development of Pure Certified Reference Material of Cannabidiol
by Congcong Yu, Ruihan Long, Feng Cao, Xinying Zhao, Tao Lan and Dunming Xu
Molecules 2024, 29(5), 921; https://doi.org/10.3390/molecules29050921 - 20 Feb 2024
Viewed by 1097
Abstract
Cannabidiol (CBD) is the major functional component in hemp and has a broad range of pharmacological applications, such as analgesic, anti-epileptic, anti-anxiety, etc. Currently, CBD is widely used in pharmaceuticals, cosmetics, and food. To ensure the quality and safety of the products containing [...] Read more.
Cannabidiol (CBD) is the major functional component in hemp and has a broad range of pharmacological applications, such as analgesic, anti-epileptic, anti-anxiety, etc. Currently, CBD is widely used in pharmaceuticals, cosmetics, and food. To ensure the quality and safety of the products containing CBD, more and more related sample testing is being conducted, and the demand for CBD-certified reference material (CRM) has also sharply increased. However, there is currently a lack of relevant reference materials. In this paper, a simple method for preparing CBD CRM was established based on preparative liquid chromatography using crude hemp extract as a raw material. A qualitative analysis of CBD was performed using techniques such as ultraviolet absorption spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), nuclear magnetic resonance spectroscopy (NMR), and differential scanning calorimetry (DSC). High-performance liquid chromatography (HPLC) was used for the homogeneity and stability tests, and the data were analyzed using an F-test and a T-test, respectively. Then, eight qualified laboratories were chosen for the determination of a certified value using HPLC. The results show that the CBD CRM had excellent homogeneity and good stability for 18 months. The certified value was 99.57%, with an expanded uncertainty of 0.24% (p = 0.95, k = 2). The developed CBD CRM can be used for the detection and quality control of cannabidiol products. Full article
(This article belongs to the Topic Purification of Plant Extracts)
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15 pages, 4419 KiB  
Article
Optimization of Cellulase-Assisted Extraction of Total Flavonoids from Equisetum via Response Surface Methodology Based on Antioxidant Activity
by Hongmei Yin, Yuanli Zhang, Tingting Hu, Wen Li, Yang Deng, Xun Wang, Huaqiao Tang, Ling Zhao and Guangwen Yan
Processes 2023, 11(7), 1978; https://doi.org/10.3390/pr11071978 - 30 Jun 2023
Cited by 1 | Viewed by 1198
Abstract
Flavonoids are one of the most essential compounds in various plants. This study used the cellulase-assisted method to extract flavonoid-enriched antioxidants from Equisetum arvense L. (EAL). According to a three-factor and three-level central composite design, the response surface methodology was used to obtain [...] Read more.
Flavonoids are one of the most essential compounds in various plants. This study used the cellulase-assisted method to extract flavonoid-enriched antioxidants from Equisetum arvense L. (EAL). According to a three-factor and three-level central composite design, the response surface methodology was used to obtain the maximum total flavonoid yield, thereby providing the most potent antioxidant activity of EAL extracts. The results indicated that the optimal condition for the total flavonoid extraction was 0.52% (base substrate) enzyme concentration and enzymolysis for 50.58 min at 49.03 °C. The extraction rate of flavonoids from horsetail reached 4.88 mg/g under these optimal conditions. The yield was 51.23% higher than that from the traditional solid–liquid extraction method. The highest DPPH-scavenging ability of the extracts obtained under 0.50% enzyme concentration and enzymolysis for 49.41 min at 46.59 °C was 77.36%. HPLC results revealed that the antioxidant substances had diverse flavonoids. Thus, the extraction condition was consistent for antioxidant activity and total flavonoids. Therefore, the current study provided an efficient method to extract flavonoid compounds from EAL, facilitating technical support for utilizing the plant. Full article
(This article belongs to the Topic Purification of Plant Extracts)
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