Topic Editors

Department of Cranio- and Maxillofacial Surgery, Hospital of the University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
Dr. Miroslaw J Szczepanski
Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment

Abstract submission deadline
31 December 2024
Manuscript submission deadline
30 June 2025
Viewed by
920

Topic Information

Dear Colleagues,

The tumor microenvironment (TME) is a complex and dynamic ecosystem that influences tumor progression, invasion, metastasis, and treatment response. It is composed of cancer cells, stromal cells, immune cells, and various components of the extracellular matrix and recent research indicates that these components communicate with each other via extracellular vesicles (EVs). EVs are small membrane-bound vesicles released by almost all cells, including cancer cells, and are known to carry various bioactive molecules, such as proteins, nucleic acids, and lipids. This topic is dedicated to the emerging understanding of how EVs contribute to the modulation of the TME. Hereby, we focus on a variety of EV-related aspects, including, but not limited to, EVs as modulators of intercellular communication, the role of EVs in remodeling the extracellular matrix, the immunomodulatory effects of EVs, and EVs as biomarkers and therapeutic targets. We hope that this topic will provide further insights into the complex role of EVs in modulating the TME and will accelerate the development of novel EV-based therapeutic strategies.

Dr. Nils Ludwig
Dr. Miroslaw J Szczepanski
Topic Editors

Keywords

  • extracellular vesicles
  • exosomes
  • tumor microenvironment
  • intercellular communication
  • immunomodulation

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomolecules
biomolecules
4.8 9.4 2011 16.9 Days CHF 2700 Submit
Current Issues in Molecular Biology
cimb
2.8 2.9 1999 13.5 Days CHF 2200 Submit
Scientia Pharmaceutica
scipharm
2.3 4.6 1930 22.7 Days CHF 1000 Submit
Cancers
cancers
4.5 8.0 2009 17.9 Days CHF 2900 Submit
Current Oncology
curroncol
2.8 3.3 1994 18 Days CHF 2200 Submit
Cells
cells
5.1 9.9 2012 16.6 Days CHF 2700 Submit

Preprints.org is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

MDPI Topics is cooperating with Preprints.org and has built a direct connection between MDPI journals and Preprints.org. Authors are encouraged to enjoy the benefits by posting a preprint at Preprints.org prior to publication:

  1. Immediately share your ideas ahead of publication and establish your research priority;
  2. Protect your idea from being stolen with this time-stamped preprint article;
  3. Enhance the exposure and impact of your research;
  4. Receive feedback from your peers in advance;
  5. Have it indexed in Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (1 paper)

Order results
Result details
Journals
Select all
Export citation of selected articles as:
13 pages, 4045 KiB  
Article
Biological Activities of Citrus-Derived Extracellular Vesicles on Human Cells: The Role of Preservation
by Theodora Karamanidou, Konstantinos Krommydas, Maria Karanikou, Dimitrios Tsamos, Konstantinos Michalakis, Dimitris Kletsas, Alexander Tsouknidas and Harris Pratsinis
Curr. Issues Mol. Biol. 2024, 46(6), 5812-5824; https://doi.org/10.3390/cimb46060347 - 11 Jun 2024
Viewed by 289
Abstract
Extracellular vesicles (EVs) have been identified as important mediators for cell-to-cell communication. Citrus-based EVs in particular offer an excellent platform for nutraceutical delivery systems, as their endemic cargo includes micronutrients (e.g., ascorbic acid), which contribute to their antioxidant capacity. Despite being extensively investigated [...] Read more.
Extracellular vesicles (EVs) have been identified as important mediators for cell-to-cell communication. Citrus-based EVs in particular offer an excellent platform for nutraceutical delivery systems, as their endemic cargo includes micronutrients (e.g., ascorbic acid), which contribute to their antioxidant capacity. Despite being extensively investigated as to their therapeutic and diagnostic potential, their cargo is inherently unstable and thus directly affected by their storage and preservation. In this study, EVs were isolated from citrus fruit using tangential flow filtration and evaluated for their physicochemical characteristics, antioxidant activity and effects on human cells. To assess how their isolation and preservation methods affect these properties, the EVs were tested immediately after isolation (from fresh and freeze-thawed juices) or following freeze-drying. A measurable biological effect of cryoprotection on citrus-derived EVs was evident, whether during or after isolation. This was more pronounced in the cell-based assays, ranging from −4% to +32% in human skin fibroblast proliferation. Nevertheless, the effects on human cancer cells varied depending on the cell line. Although these results should be considered preliminary observations, subject to further investigation, it is safe to state that any type of preservation is expected to impact the EVs’ biological activity. Full article
Show Figures

Graphical abstract

Back to TopTop