Magnetic Biology and Bioelectromagnetic Technology

Topic Information

Dear Colleagues,

This Topic centers on magnetic biology and interdisciplinary applications, covering five core research directions to balance fundamental research, technological innovation, and translational applications. It includes basic mechanisms of magnetic field–biology interactions, covering biological effects, molecular pathways, and endogenous magnetic sensing; novel bioelectromagnetic devices, precise control systems, signal detection, and multi-modal integrated platforms; biomedical and clinical applications such as magnetic-assisted therapy, targeted delivery, magnetic hyperthermia, and neural regulation; environmental, agricultural, and food applications including pollutant treatment, crop regulation, and food processing; and integration of magnetic nanomaterials with bioelectromagnetic technology for biosensing, imaging, targeted therapy, and biosafety evaluation.

We welcome original research articles, reviews, and communications focusing on the design, synthesis, surface engineering, and biomedical assessment of magnetic nanostructures for cancer theranostics and precision healthcare.

Dr. Chao Song
Dr. Lin Chen
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	8.2	14.7	2012	18.7 Days	CHF 2900	Submit
Biology biology	4.3	7.3	2012	16.8 Days	CHF 2700	Submit
Biophysica biophysica	1.8	2.6	2021	15.7 Days	CHF 1200	Submit
Cancers cancers	4.8	9.0	2009	19.1 Days	CHF 2900	Submit
Cells cells	6.0	11.4	2012	15.5 Days	CHF 2700	Submit
Magnetism magnetism	1.2	2.3	2021	27.5 Days	CHF 1000	Submit
Magnetochemistry magnetochemistry	2.8	5.8	2015	18.9 Days	CHF 2200	Submit

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Published Papers (1 paper)

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All Biology Cancers Magnetism Magnetochemistry Antioxidants Cells Biophysica

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18 pages, 17523 KB  

Open AccessArticle

Combined Electromagnetic Fields Mitigate Unloading-Induced Bone Loss by Enhancing Osteogenic Responses via Multiphysics-Induced Mechanotransduction

by Chao Cai, Shenghang Wang, Junyu Liu, Mengxuan Zheng, Weihao Ren, Fengyi Xue, Xin Zhang, Bo Zong, Jiancheng Yang, Weikang Sun, Zhihua Li, Tinghua He, Xiaotong Zhang and Peng Shang

Cells 2026, 15(13), 1138; https://doi.org/10.3390/cells15131138 - 23 Jun 2026

Viewed by 138

Abstract

Unloading-induced bone loss is a major medical challenge during long-duration human spaceflight, largely driven by suppressed osteoblast-mediated bone formation, and practical countermeasures are needed. Electromagnetic stimulation has shown benefits for bone repair, and its non-invasiveness supports potential space use; however, its single-modality efficacy [...] Read more.

Unloading-induced bone loss is a major medical challenge during long-duration human spaceflight, largely driven by suppressed osteoblast-mediated bone formation, and practical countermeasures are needed. Electromagnetic stimulation has shown benefits for bone repair, and its non-invasiveness supports potential space use; however, its single-modality efficacy remains limited. Here, we investigated a combined electromagnetic field (CEMF) integrating a static magnetic field (SMF, 0.4–0.6 T) and a pulsed electromagnetic field (PEMF, 0.38 ± 0.19 mT) to attenuate unloading-related bone loss and examine field-induced mechanical stimulation. Finite-element simulations mapped magnetic flux density, field gradient, induced current density, and Lorentz force density in bone tissue. CEMF was evaluated in vivo in hindlimb unloading (HLU) mice and in vitro in MC3T3-E1 osteoblasts. CEMF improved bone mineral density, trabecular and cortical microarchitecture, and mechanical properties in HLU mice, with increased osteoblast number and mineral apposition rate. In vitro, CEMF promoted osteogenic differentiation and upregulated COL1A1 and RUNX2. Transcriptome analysis suggested activation of ECM–integrin mechanical signaling and the PI3K–AKT pathway. These findings indicate that CEMF-induced multiphysics stimulation enhances osteogenic responses and may serve as a complementary, non-invasive countermeasure for spaceflight-associated bone loss. Full article

(This article belongs to the Topic Magnetic Biology and Bioelectromagnetic Technology)

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