Lipid Metabolism in Human Health and Diseases

Topic Information

Dear Colleagues,

Lipid metabolism plays a central role in maintaining cellular homeostasis and energy balance, and its dysregulation is a hallmark of numerous human diseases. From cardiovascular disorders and kidney-liver health to neurodegenerative conditions and cancer, altered lipid handling contributes significantly to disease pathogenesis and progression.

This Topic aims to provide a comprehensive overview of current advances in understanding the molecular and cellular mechanisms governing lipid metabolism in health and disease. Particular emphasis is placed on pathways regulating lipid synthesis, transport, storage, and degradation, as well as their integration with systemic metabolic networks. In addition to mechanistic insights, this issue seeks to highlight translational and clinical perspectives, including biomarker discovery, therapeutic targeting of lipid pathways, and precision medicine approaches.

We welcome original research and review articles exploring these themes and contributing to the advancement of this dynamic field.

Dr. Dimitris Kounatidis
Dr. Iordanis Mourouzis
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomedicines biomedicines	4.5	7.8	2013	18.2 Days	CHF 2600	Submit
Biomolecules biomolecules	5.6	9.3	2011	16.6 Days	CHF 2700	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Life life	3.9	7.1	2011	15.3 Days	CHF 2600	Submit
Lipidology lipidology	-	-	2024	19.8 Days	CHF 1000	Submit
Metabolites metabolites	4.5	8.1	2011	12.6 Days	CHF 2700	Submit
Nutrients nutrients	5.8	10.2	2009	15.8 Days	CHF 2900	Submit

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Published Papers (2 papers)

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All Biomedicines Biomolecules IJMS Lipidology Metabolites Life Nutrients

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26 pages, 3107 KB  

Open AccessReview

Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications

by Chen Wang and Xianglu Rong

Biomolecules 2026, 16(7), 1031; https://doi.org/10.3390/biom16071031 - 14 Jul 2026

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Abstract

Leptin is the oldest studied adipokine, and its mechanism of action in the regulation of energy metabolism remains a hot topic of current research. In this paper, we systematically review the progress of clinical and basic research on leptin and energy metabolism from [...] Read more.

Leptin is the oldest studied adipokine, and its mechanism of action in the regulation of energy metabolism remains a hot topic of current research. In this paper, we systematically review the progress of clinical and basic research on leptin and energy metabolism from 1994 to 2026. It is shown that leptin can regulate the energy metabolism homeostasis through autocrine, paracrine and neurohumoral pathways (e.g., hypothalamic–leptin–melanocortin axis). In addition, the effects of mainstream weight loss strategies such as dietary control, pharmacological interventions and exercise on leptin levels, and their underlying mechanisms were investigated in this paper, with the aim of providing a theoretical basis for the clinical application of leptin in metabolic diseases (e.g., obesity, diabetes mellitus). Future studies need to further clarify the molecular mechanisms of leptin resistance and explore precise intervention strategies based on the leptin signaling pathway. Full article

(This article belongs to the Topic Lipid Metabolism in Human Health and Diseases)

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11 pages, 419 KB  

Open AccessArticle

The Interaction Between HDL-C Level and HNF4A rs4812829 on Incident Type 2 Diabetes Risk in a Chinese Cohort

by Haodong Zhang, Yixin Li, Yinxi Tan, Huangda Guo, Hexiang Peng, Yi Zheng, Yiqun Wu, Xueying Qin, Tao Wu, Dafang Chen, Yonghua Hu and Mengying Wang

Nutrients 2026, 18(14), 2270; https://doi.org/10.3390/nu18142270 - 11 Jul 2026

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Abstract

Background/Objectives: To evaluate the association between HNF4A rs4812829 and type 2 diabetes (T2D) in a rural Chinese population and to investigate its interaction with blood lipids in the association. Methods: A total of 4496 participants free of diabetes at baseline from [...] Read more.

Background/Objectives: To evaluate the association between HNF4A rs4812829 and type 2 diabetes (T2D) in a rural Chinese population and to investigate its interaction with blood lipids in the association. Methods: A total of 4496 participants free of diabetes at baseline from a family-based cohort in rural China were included. Demographic, lifestyle, and medical history data were collected via standardized questionnaires. Anthropometric and biochemical measurements were performed using standardized protocols and automated assays on fasting blood samples. Mixed-effects Cox proportional hazards models, accounting for familial clustering, were employed to examine the association between HNF4A rs4812829 and incident T2D risk. Additionally, multiplicative interaction terms were used to assess interactions. Results: After a median follow-up of 10.76 years, 895 incident T2D cases were identified. Under an additive genetic model, each additional G allele of rs4812829 was significantly associated with an increased risk of T2D (HR 1.38, 95% CI 1.19–1.59). A significant multiplicative interaction was observed between rs4812829 and HDL-C (p = 0.004). In genotype-stratified analyses, higher HDL-C levels were strongly associated with lower T2D risk among AA homozygotes (HR 0.04, 95% CI 0.003–0.43) and AG heterozygotes (HR 0.30, 95% CI 0.10–0.84), but not among GG homozygotes (HR 1.32, 95% CI 0.35–4.91). Conclusions: This study finds HNF4A intronic variant rs4812829 is significantly associated with the incident T2D risk in a rural Chinese population, and this association exhibits an interaction with HDL-C levels. These findings support further investigation of HNF4A-related lipid pathways and require replication in independent Chinese and multi-ancestry cohorts before genetic and lipid profiles can be considered for T2D risk stratification. Full article

(This article belongs to the Topic Lipid Metabolism in Human Health and Diseases)

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