Cancer and Chronic Disease: Molecular Mechanisms and Translational Oncology in Multimorbidity
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 85
Special Issue Editors
Interests: breast tumor kinase (BRK) and two other BRK family members; FRK and SRMS
Interests: cancer biology; cancer biomarkers; pancreatic cancer; gastric cancer; lung cancer; B-cell lymphoma; transcription regulation; epigenetics; DNA methylation; microRNAs; neural differentiation; genetic diseases; extracellular matrix proteins
Special Issues, Collections and Topics in MDPI journals
Interests: retina; oxidative stress; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: immunotherapy; immunology; cancer and cell biology; targeted therapies; biomarkers; developmental pathways
Special Issues, Collections and Topics in MDPI journals
Interests: epigenetic regulation in normal hematopoiesis and in hematological malignancies; role of Notch signalling in leukaemia; signalling pathways in hematological malignancies within the bone marrow microenvironment
Special Issue Information
Dear Colleagues,
Background
Cancer and chronic diseases such as diabetes, cardiovascular disease, and hypertension are increasingly interconnected and frequently coexist. Type 2 diabetes is associated with a higher risk of several cancers, while hypertension appears to be linked to cancer through shared risk factors and overlapping biological pathways rather than a simple direct causal relationship. Common mechanisms may include chronic inflammation, metabolic dysregulation, oxidative stress, immune dysfunction, and aberrant signaling pathways.
Importance
As multimorbidity becomes more prevalent, studying cancer and chronic disease in isolation is no longer sufficient. A better understanding of their shared molecular basis may help identify biomarkers, clarify disease progression, and support the development of more effective precision medicine strategies. Particular attention should be given to mechanisms such as epigenetic dysregulation, chronic inflammation, metabolic imbalance, and microenvironmental remodeling, which are increasingly recognized as relevant to both cancer and chronic disease biology.
Goals of the Special Issue
This Special Issue seeks high-quality contributions exploring the molecular interplay between cancer and chronic disease. Topics of interest include epigenetic regulation, chronic inflammation, metabolic dysfunction, molecular aberrations, and related mechanisms involved in disease initiation, progression, and treatment response. We welcome basic, translational, and clinical studies that improve mechanistic understanding and support innovative therapeutic approaches in the context of multimorbidity.
Prof. Dr. Kiven Erique Lukong
Dr. Giorgio Malpeli
Dr. Marco Feligioni
Dr. Paul Takam Kamga
Dr. Armel Nwabo Kamdje
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- chronic diseases
- multimorbidity
- molecular mechanisms
- epigenetics
- chronic inflammation
- molecular aberrations
- translational oncology
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