Novel Research on Physiologically-Based Pharmacokinetic Modeling
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 373
Special Issue Editors
Interests: physiologically-based pharmacokinetic modeling; drug–drug interactions; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals
Interests: PBPK modeling; drug-drug interactions; special populations; drug-induced liver injury
Special Issue Information
Dear Colleagues,
Physiologically based pharmacokinetic (PBPK) modeling has rapidly evolved into a core component of model-informed drug development, allowing mechanistic integration of drug properties with human physiology to support evidence-based decision-making. The growing regulatory acceptance of PBPK has accelerated its use in addressing complex clinical questions, including dose optimization in vulnerable populations, prediction of drug–drug interactions, characterization of transporter and enzyme contributions, biowaiver justification, and virtual clinical trial simulation.
This Special Issue, titled “Novel Research on Physiologically Based Pharmacokinetic Modeling”, highlights cutting-edge applications that demonstrate the expanding impact of PBPK across therapeutic areas and drug modalities. We invite submissions presenting innovative modeling frameworks, integration with pharmacodynamics or disease models, incorporation of in vitro and preclinical data, and quantitative evaluation of mechanistic hypotheses. Research leveraging PBPK to inform pediatric dosing, geriatric considerations, renal or hepatic impairment, genetic variability, long-acting formulations, and complex biologics is particularly welcome. Through original research articles, methodological advances, and comprehensive reviews, this Special Issue aims to provide a platform for novel insights and practical contributions that enhance the reliability, transparency, and translational value of PBPK modeling in drug development and clinical practice.
Dr. Xiaoqiang Xiang
Dr. Qingfeng He
Dr. Yufei Shi
Guest Editors
Manuscript Submission Information
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Keywords
- physiologically based pharmacokinetics
- drug–drug interactions
- in vitro–in vivo extrapolation
- special populations
- virtual clinical trials
- quantitative pharmacology
- mechanistic modeling
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