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The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 453

Special Issue Editor


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Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
Interests: laying hens; stress; animal welfare; animal behavior; neurophysiology
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Special Issue Information

Dear Colleagues,

Metabolism-related pathways, such as lipid metabolism pathway, insulin signaling pathway, and AMP-activated protein kinase pathway, are currently in the spotlight due to their broad impact on animal growth, development, energy balance, and behavior, all of which occur through a complex network of interactions. In-depth studies of the molecular mechanisms and intrinsic connections of these metabolic pathways will enhance our understanding of their critical roles in animal growth, development, and behavior.

In light of this, led by Prof. Runxiang Zhang, and assisted by Dr. Hui Yuan (Northeast Agricultural University), the objective of this Special Issue is to collect reports on the role of metabolism-related pathways in animal growth, development, disease, and behavior. We invite researchers to submit original research articles, opinion papers, reviews, and short communications that present current findings and future directions related to metabolism-related pathways. We look forward to receiving your valuable submissions.

Prof. Dr. Runxiang Zhang
Guest Editor

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Keywords

  • metabolism pathway
  • signal pathway
  • animal development
  • animal behavior
  • animal disease

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Published Papers (1 paper)

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Research

13 pages, 794 KiB  
Communication
Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates Hepatic TNF-α, PPAR-α, and PPAR-δ mRNA in Postparturient Holstein–Friesian Cows
by Katarzyna Żarczyńska, Katarzyna Różańska, Paweł Brym and Dawid Tobolski
Int. J. Mol. Sci. 2025, 26(16), 8018; https://doi.org/10.3390/ijms26168018 - 19 Aug 2025
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Abstract
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study [...] Read more.
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study investigated the effects of supplementing periparturient Holstein–Friesian cows with orally administered selenitetriglycerides (0.5 mg Se/kg body weight/day starting 12 days before the expected calving date and continuing until parturition) on antioxidant enzyme activity and on the hepatic expression of key inflammatory and metabolic genes. Serum selenium concentrations and erythrocyte glutathione peroxidase (GSH-Px) activity were assessed before and after parturition, and hepatic gene expression levels of tumor necrosis factor alpha (TNF-α), peroxisome proliferator-activated receptor alpha (PPAR-α) and delta (PPAR-δ) were assessed 24 h and 7 days postpartum. Supplemented cows showed significantly elevated serum Se levels and increased GSH-Px activity, reflecting improved antioxidant capacity. Moreover, hepatic expression of TNF-α and PPAR-δ was significantly reduced postpartum in the supplemented group, whereas PPAR-α expression remained stable. These findings indicate that selenitetriglycerides effectively enhance antioxidant defenses, moderate inflammation, and stabilize metabolic pathways during the periparturient phase, potentially reducing postpartum metabolic disorders and improving dairy-cow health. Full article
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