Search Results (721)

Purpose: To effectively reduce cancer burden, genetic testing programs should identify high-risk individuals prior to cancer development, when risk-reduction strategies can be implemented. We evaluated trends in BRCA1/BRCA2 testing use after implementation of a publicly funded testing program. Methods: We conducted a retrospective, near population-based study of women who underwent BRCA1/BRCA2 testing in Ontario, Canada, (2007–2016) (n = 15,986). Temporal trends were evaluated using linear and Poisson regression. Results: Although annual utilization of testing increased over time (p < 0.001), mean age at testing increased from 49.9 years (SD 13.8) in 2007 to 53.8 years (SD 13.7) in 2016 (p < 0.001). The proportion of women with a cancer history at testing also increased from 53.5% in 2007 to 66.3% in 2015 (p < 0.001); the proportion of women free from breast cancer did not change significantly (49.2% in 2007 versus 45.1% in 2015, p = 0.90). As a proportion of all tested, those with breast cancer tested within 3 months of diagnosis increased over time (0.39% of tests in 2007 versus 13.6% of tests in 2015; p < 0.001). Conclusions: While the institution of a publicly funded genetic testing program was associated with rising utilization, increasing age at testing and decreasing testing of unaffected women suggest limitations in identifying high-risk individuals eligible for risk-reduction. Full article

Distributed generation strengthens distribution network reliability by placing generators close to load centers. The integration of electric vehicle charging stations (EVCSs) with PV systems mitigates the effects of EV charging burden. In this research, the objective is to combineEVCSs with distributed generation (DG) units in the Puducherry smart grid system to obtain optimized locations and enhance their reliability. To determine the right nodes for DGs and EVCSs in an uneven distribution network, the modified decision-making (MDM) algorithm and the model predictive control (MPC) approach are used. The Indian utility 29-node distribution network (IN29NDN), which is an unbalanced network, is used for testing. The effects of PV systems and EVCS units are studied in several settings and at various saturation levels. This study validates the correctness of its findings by evaluating the outcomes of proposed methodological approaches. DIgSILENT Power Factory is used to conduct the simulation experiments. The results show that optimizing the location of the DG unit and the size of the PV system can significantly minimize power losses and make a distribution network (DN) more reliable. Full article

Social anxiety is a prevalent mental health concern among college students, often intensified by academic and interpersonal pressures on campus. This study investigated the relationship between physical activity, loneliness, and social anxiety among college students, aiming to examine the mediating role of loneliness in the process of physical activity affecting social anxiety, as well as the moderating role of gender in this mediating effect. A cross-sectional research design was adopted, and data on physical activity levels, loneliness, and social anxiety were collected through questionnaires completed by 638 students at a university in China. This study conducted a single-factor Harman test, descriptive statistical analysis, reliability analysis, correlation analysis, and independent-samples t-tests, and it modeled the moderated mediation effect. The results showed that physical activity was significantly and negatively correlated with both loneliness and social anxiety. Loneliness played a mediating role in the influence of physical activity on social anxiety, and this mediating effect was moderated by gender, being more pronounced in the female group. This study concluded that physical activity can help alleviate social anxiety, but the mechanism involving the reduction of loneliness is more apparent in women, indicating the need to consider gender differences when developing interventions, as there may be other, more significant reasons for men. Full article

We examined the associations between individual differences in intensive longitudinal data-derived affective dynamics (i.e., positive and negative affect variability and inertia and positive affect–negative affect bipolarity) and concurrent stress, drinking levels, and affect-regulation drinking motives across three time points spanning early adulthood. This allowed us to evaluate the stability of the affective dynamics and whether their associations with alcohol outcomes varied across this critical developmental period. Moderate-to-heavy college drinkers (N = 1139, 51% women) reported on their affective states, stress, drinking levels, and drinking motives daily for 30 days using a web-based daily diary in three assessment waves: during college and at two post-college waves, approximately 5 and 10 years after the initial assessment. Findings indicated moderate stability of the affect dynamic indicators, except for inertia. Negative affect variability showed the strongest positive association with mean daily stress. Individuals who demonstrated stronger affect bipolarity had lower drinking levels and higher enhancement motivation. None of the other dynamic indicators were consistently related to the drinking outcomes in the predicted direction after controlling for mean affect levels, and we found little evidence for changes in these effects across time. Our results add to the inconsistent literature regarding the associations between affective dynamics and alcohol-related outcomes. Full article

Gender harassment is the most common variant of sexual harassment and is often seen in male-dominated workplaces. Importantly, persistent gender harassment produces pronounced impairment in psychological and occupational domains. The current study aimed to examine the degree to which male dominated academic degree programs are associated with higher rates of sexual harassment compared to female dominated programs. Four academic fields were chosen for their gender disparity—business, engineering, health sciences, and education. Consistent with hypotheses, cisgender women students in the college of engineering were most likely to experience gender harassment by peers and faculty. Implications and future directions are discussed. Full article

Despite advances in cancer care, disparities persist. The collection of the social determinants of health (SDOH) is fundamental to addressing disparities. However, SDOH are inconsistently collected in many regions of the world. This two-phase multiple methods study examined patient and community perspectives regarding SDOH data collection in Canada. In phase 1, a survey was administered to patients at a cancer centre (n = 549) to assess perspectives on an SDOH data collection tool. In phase 2, broader perspectives were sought through a community consultation with patient partners experiencing structural inequality (n = 15). Most participants were comfortable with SDOH data collection. Of survey respondents, 95% were comfortable with the collection of language, birthplace, sex, gender, education, and disability, and 82% to 94% were comfortable with SES, sexual orientation, social support, and race/ethnicity. Discomfort levels did not differ across subgroups, except women were more uncomfortable disclosing SES (OR: 2.00; 95%CI: 1.26, 3.19). Most (71%) preferred face-to-face data collection with a healthcare professional and only half were comfortable with storage of SDOH in electronic health records. Open-ended survey responses (n = 1533) and the community consultation revealed concerns about privacy, discrimination, relevance to care, and data accuracy. SDOH data collection efforts should include a clear rationale for patients, training for providers, strong data privacy and security measures, and actionable strategies to address needs. Full article

In recent years, remote sensing and geographic information systems (GISs) have become essential tools for effective landscape management. This study utilizes these technologies to analyze land use and land cover (LULC) changes in Dibru-Saikhowa National Park, a riverine ecosystem in Assam, India, from its designation as a national park in 2000 through 2024. The satellite imagery was used to classify LULC types and track landscape changes over time. In 2000, grasslands were the dominant land cover (28.78%), followed by semi-evergreen forests (25.58%). By 2013, shrubland became the most prominent class (81.31 km²), and degraded forest expanded to 75.56 km². During this period, substantial areas of grassland (29.94 km²), degraded forest (10.87 km²), semi-evergreen forest (12.33 km²), and bareland (10.50 km²) were converted to shrubland. In 2024, degraded forest further increased, covering 80.52 km² (23.47%). This change resulted since numerous areas of shrubland (11.46 km²) and semi-evergreen forest (27.48 km²) were converted into degraded forest. Furthermore, significant shifts were observed in grassland, shrubland, and degraded forest, indicating a substantial and consistent decline in grassland. These changes are largely attributed to recurring Brahmaputra River floods and increasing anthropogenic pressures. This study recommends a targeted Grassland Recovery Project, control of invasive species, improved surveillance, increased staffing, and the relocation of forest villages to reduce human impact and support community-based conservation efforts. Hence, protecting the landscape through informed LULC-based management can help maintain critical habitat patches, mitigate anthropogenic degradation, and enhance the survival prospects of native floral and faunal assemblages in DSNP. Full article

Classroom management is an essential yet frequently under-practiced competency in undergraduate teacher education, with important implications for sustainable teacher preparation. This study investigated whether pre-service teachers who feel more capable of managing classrooms also engage more deeply with simulation-based training. Fifty-seven Korean pre-service teachers (15 men, 42 women), all undergraduate students enrolled in a secondary teacher education program at a college of education, completed a five-item classroom-management-efficacy scale, then experienced a 15 min branching simulation that required choosing recognition, punishment, or aggression strategies in response to a disrespectful virtual student. Interest was assessed immediately afterwards with a 24-item instrument covering the four phases of the interest-development model (triggered situational, maintained situational, emerging individual, and well-developed individual). A post-test comparative design and MANOVA revealed that efficacy level had a significant multivariate effect on overall interest (Wilks Λ = 0.78, p = 0.029, partial η² = 0.12). Scheffe contrasts showed that high-efficacy participants outscored their low-efficacy peers on maintained situational and emerging individual interest, p < 0.05, and surpassed the middle-efficacy group in three of the four phases. Repeated measures ANOVA confirmed a general decline from situational to individual interest across all groups (F (3, 52) = 9.23, p < 0.01), underscoring the difficulty of converting short-term curiosity into lasting commitment. These findings position classroom-management efficacy as a key moderator of engagement and support the use of adaptive simulations as sustainable tools for teacher education. By tailoring challenge levels and feedback to participants’ efficacy, guided simulations can foster deeper engagement and promote individualized growth—helping build resilient and well-prepared educators. Full article

Background/Objectives: Accurately correlating mammographic findings with corresponding histopathologic features is considered one of the essential aspects of mammographic evaluation, guiding the next steps in cancer management and preventing overdiagnosis. The objective of this study was to evaluate patterns of mammographic microcalcifications and their association with histopathological findings related to various breast tumors. Methods: 110 out of 3603 women had microcalcification of BIRADS 3 or higher and were subjected to stereotactic/ultrasound (USG) guided biopsies, and hook-wire localization excision procedures. Ultrasound and mammography images were reviewed by experienced radiologists using the standard American College of Radiology Breast-Imaging Reporting and Data System (ACR BI-RADS). Results: Our study showed that features with a high positive predictive value (PPV) of breast malignancy were heterogeneous (75%), fine linear/branching pleomorphic microcalcifications (66.7%), linear (100%), and segmental distributions (57.1%). Features that showed a higher risk of association with ductal carcinoma in situ (DCIS) were fine linear/branching pleomorphic (odds ratio (OR): 3.952), heterogeneous microcalcifications (OR: 3.818), segmental (OR: 5.533), linear (OR: 3.696), and regional (OR: 2.929) distributions. Furthermore, the features with higher risks associated with invasive carcinoma had heterogeneous (OR: 2.022), fine linear/branching pleomorphic (OR: 1.187) microcalcifications, linear (OR: 6.2), and regional (OR: 2.543) distributions. The features of associated masses in mammograms that showed a high PPV of malignancy had high density (75%), microlobulation (100%), and spiculated margins (75%). Conclusions: We concluded that specific patterns and distributions of microcalcifications were indeed associated with a higher risk of malignancy. Those with fine linear or branching pleomorphic and segmental distribution were at a higher risk of DCIS, whereas those with heterogeneous morphology with a linear distribution were at a higher risk of invasive carcinoma. Full article

Depression and anxiety are the most prevalent mental health concerns among college students. In addition to the typical college stressors, Hispanic students may experience minority status stress associated with their membership in a socially stigmatized ethnic and cultural group. Ethnic minority status stress has been positively associated with psychological distress. Therefore, this study examined, among Hispanic college students, (a) gender differences in the associations of ethnic minority status stress and social support to depression and anxiety symptoms, (b) if social support buffered the association of minority stress with depression and anxiety symptoms, and (c) if the social support moderation effect differed by gender. The results indicated that the negative association of social support to depression symptoms was stronger for women than men and that social support buffered the association of ethnic minority status stress to depression symptoms only for women. The negative association of minority status stress to depression symptoms was statistically significant only for women who reported lower levels of social support. No gender or social support moderation effects were observed in relation to anxiety symptoms for women or men. The results highlight the importance of social support in ameliorating the potential impact of ethnic minority status stress on psychological distress among Hispanic college women. Full article

Background/Objectives: To correlate blood lead (Pb) levels with cancer risk in a prospective cohort of healthy women with non-occupational exposure to lead. We hypothesize that blood Pb levels can predict the risk of cancer in healthy women. Methods: The study was performed with women registered at the Hereditary Cancer Centre, Szczecin, aged 40 years and above between September 2010 and March 2024. A total of 2927 unaffected women were included in the study. Exclusion criteria were BRCA1 gene mutation, women with diagnosed cancer, and women with occupational exposures to Pb. All patients were asked about their occupational exposure and tested for the three Polish BRCA1 founder mutations (c.5266dupC/5382insC; c.181T > G/300T > G; c.4035delA/4153delA). Inductively coupled plasma mass spectrometry was used to measure blood Pb levels. The study was blinded to all scientists involved, and all samples were assayed in the absence of any knowledge about the clinical status of each participant. Results: There were 239 incident cancers diagnosed in the cohort after an average follow-up of 6 years. Compared to women with the lowest blood Pb concentration, women with higher blood Pb levels had a significantly increased risk of developing any cancer (HR = 1.46; (95% CI: 1.006–2.13; p = 0.046)). The association was stronger for women below the age of 50 years at study entry (HR = 2.59; (95% CI: 1.37–4.89; p = 0.003)). For women over 50 years of age, the results were statistically insignificant. Conclusions: This study suggests that blood Pb levels have the potential to be used as a marker of cancer risk in women under 50 years of age who have no known occupational exposure to this heavy metal. Further investigations using additional groups of women from Poland and other countries are needed for validate these findings. Full article

Ensuring that older adults perform chair-based exercises (CBEs) correctly is essential for improving physical outcomes and reducing the risk of injury, particularly in home and community rehabilitation settings. However, evaluating the correctness of movements accurately and objectively outside clinical environments remains challenging. In this study, camera-based methods have been used to evaluate practical exercise quality. A single-camera system utilizing MediaPipe pose estimation was used to capture joint angle data as twenty older adults performed eight CBEs. Simultaneously, surface electromyography (sEMG) recorded muscle activity. Participants were guided to perform both proper and commonly observed incorrect forms of each movement. Statistical analyses compared joint angles and sEMG signals, and a support vector machine (SVM) was trained to classify movement correctness. The analysis showed that correct executions consistently produced distinct joint angle patterns and significantly higher sEMG activity than incorrect ones (p < 0.001). After modifying the selection of joint angle features for Movement 5 (M5), the classification accuracy improved to 96.26%. Including M5, the average classification accuracy across all eight exercises reached 97.77%, demonstrating the overall robustness and consistency of the proposed approach. In contrast, high variability across individuals made sEMG less reliable as a standalone indicator of correctness. The strong classification performance based on joint angles highlights the potential of this approach for real-world applications. While sEMG signals confirmed the physiological differences between correct and incorrect executions, their individual variability limits their generalizability as a sole criterion. Joint angle data derived from a simple single-camera setup can effectively distinguish movement quality in older adults, offering a low-cost, user-friendly solution for real-time feedback in home and community settings. This approach may help support independent exercise and reduce reliance on professional supervision. Full article

GEN1 is implicated in DNA damage repair, as are several other breast cancer susceptibility genes, and is included in several comprehensive next-generation sequencing (NGS) testing panels. To investigate the possible association of GEN1 variants with breast cancer risk, we sequenced this gene in 617 Polish women with hereditary breast cancer (HBC) and 300 Polish cancer-free controls. No protein-truncating variants were detected in the conserved part of GEN1 (first 480 codons). Two frameshift variants were detected in the last exon of GEN1: c.2515_2519delAAGTT (p.Lys839Glufs*2) and c.1929_1932delAAAG (p.Lys645Cysfs*29). The p.Lys839Glufs*2 variant was detected in 21.1% of 617 HBC cases and 18.4% of 300 controls (p = 0.38). The p.Lys645Cysfs*29 variant was rare, seen in 0.6% of 617 HBC cases and 0.3% of 300 controls. The variant was then detected in 38 (0.24%) of 15,930 unselected breast cancer cases and 8 (0.17%) of 4702 cancer-free female controls from Poland (OR = 1.40, p = 0.49). Clinical characteristics of breast tumors in the 38 carriers of p.Lys645Cysfs*29 and 15,892 non-carriers were similar. Survival was similar among variant carriers and non-carriers (the age-adjusted HR = 0.87, p = 0.76). The wild-type GEN1 allele was retained in all five breast cancers of carriers of p.Lys645Cysfs*29. No cancer type was more frequent in the relatives of 35 p.Lys645Cysfs*29 variant carriers compared to the relatives of 14,592 non-carriers. We conclude that GEN1 is unlikely to be a high or moderate-risk breast cancer susceptibility gene. Our study has clinical implications for genetic counseling and suggests that GEN1 changes should be reclassified as variants of uncertain significance (VUS) when they are detected in clinical testing panels. Full article

The acceptance of myths about intimate partner violence against women by university students can lead to inappropriate and biased professional interventions due to their gender blindness. The aim of this study is to analyze the acceptance of myths about IPVAW among college students, considering differences by gender and degree course. To do this, we conducted a survey with 1531 first-year college students (55.8% women; mean age 18.89 years) and found that a third of the students did not reject the IPVAW myths and a third of them normalized violence. We also found a higher level of acceptance of violence minimization myths in men than in women, especially in Social Sciences and Engineering. The study reveals the need to educate future professionals about IPVAW myths, with an emphasis on minimization and normalization of violence. It also provides useful information for designing awareness programs. Full article

Background/Objectives: Frailty is a multifactorial condition influenced by physical and psychosocial factors. Understanding longitudinal changes in these domains may guide prevention strategies. This study examines the relationship between frailty status, physical fitness, and psychosocial conditions in community-dwelling older adults using five-year longitudinal data. Methods: Participants were 52 out of 89 older adults who completed both baseline and five-year follow-up assessments (follow-up rate: 58.4%). Data were collected using 10 physical fitness indicators, the fitness age score (FAS), geriatric depression scale (GDS), Lubben social network scale short form (LSNS-6), and relevant items in the six Kihon Checklist (KCL) domains. Due to low prevalence of frailty, individuals with pre-frailty and frailty were combined into the frailty-risk group. Repeated measures ANOVA with sex as a covariate was conducted to compare groups. Logistic regression was used to identify baseline predictors of frailty status at five years. Statistical significance was set at p < 0.05. Results: GDS, LSNS-6, and KCL scores remained stable over five years. However, physical fitness significantly declined in several measures, including grip strength, vertical jump height, knee extension strength, functional reach, and FAS. A significant interaction for the timed up and go test showed that the robust group maintained function, while the frailty-risk group declined. Logistic regression identified KCL oral function as a significant predictor (OR = 5.331, 95% CI = 1.593–17.839, p = 0.007). Conclusions: Maintaining both oral function and physical fitness is vital for preventing frailty, even among health-conscious older adults. Proactive strategies may support healthy aging. Full article