Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Chart Abstraction
2.3. Administrative Record Linkage
2.4. Data Analysis
3. Results
3.1. Cohort Characteristics
3.2. Test Utilization
3.3. Age at Testing
3.4. Cancer History
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | All Participants (n = 15,986) | Non-Predictive Testing (n = 13,619, 85.2%) | Predictive Testing (n = 2367, 14.8%) | p-Value | |
---|---|---|---|---|---|
Age at first test (median, IQR) | 53 (43–63) | 54 (45–64) | 44 (33–57) | <0.001 | |
Ancestry (%) | |||||
European | 10,130 (63.4) | 8519 (62.6) | 1611 (68.1) | <0.001 | |
Southeast Asian | 1048 (6.6) | 952 (7.0) | 96 (4.1) | <0.001 | |
Central/South Asian or Middle Eastern | 1282 (8.0) | 1114 (8.2) | 168 (7.1) | 0.08 | |
African/Caribbean | 606 (3.8) | 522 (3.8) | 84 (3.5) | 0.54 | |
Latin/Hispanic | 495 (3.1) | 449 (3.3) | 46 (1.9) | 0.001 | |
Other | 880 (5.5) | 681 (5.0) | 199 (8.4) | <0.001 | |
Unknown | 3023 (18.9) | 2599 (19.1) | 424 (17.9) | 0.19 | |
Ashkenazi Jewish (%) | 2946 (18.4) | 2663 (19.6) | 283 (10.9) | <0.001 | |
Neighborhood income quintile (%) | <0.001 | ||||
Rural | 1340 (8.4) | 1083 (8.0) | 257 (10.9) | ||
Urban, lowest quintile | 1940 (12.1) | 1657 (12.2) | 283 (12.0) | ||
Urban, second quintile | 2378 (14.9) | 2046 (15.0) | 332 (14.0) | ||
Urban, third quintile | 2522 (15.8) | 2136 (15.7) | 386 (16.3) | ||
Urban, fourth quintile | 3298 (20.6) | 2811 (20.6) | 487 (20.6) | ||
Urban, highest quintile | 4481 (28.0) | 3864 (28.4) | 617 (26.1) | ||
Marginalization summary score (mean, SD) | 3.03 (0.77) | 3.03 (0.77) | 2.99 (0.75) | 0.01 | |
Year of first test (%) | <0.001 | ||||
2007–2009 | 2933 (18.3) | 2407 (17.7) | 526 (22.2) | ||
2010–2012 | 4616 (28.9) | 3845 (28.2) | 771 (32.6) | ||
2013–2016 | 8437 (52.8) | 7367 (54.1) | 1070 (45.2) | ||
Result of first test (%) | <0.001 | ||||
Positive | 2034 (12.7) | 1077 (7.9) | 957 (40.4) | ||
Variant of uncertain significance | 1166 (7.3) | 1134 (8.3) | 32 (1.4) * | ||
Negative | 11,408 (71.4) | 11,408 (83.8) | 0 (0) | ||
Predictive Negative | 1377 (8.6) | 0 (0) | 1377 (58.2) |
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Dossa, F.; Baxter, N.N.; Sutradhar, R.; Little, T.; Velsher, L.; Lerner-Ellis, J.; Eisen, A.; Metcalfe, K. Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program. Curr. Oncol. 2025, 32, 439. https://doi.org/10.3390/curroncol32080439
Dossa F, Baxter NN, Sutradhar R, Little T, Velsher L, Lerner-Ellis J, Eisen A, Metcalfe K. Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program. Current Oncology. 2025; 32(8):439. https://doi.org/10.3390/curroncol32080439
Chicago/Turabian StyleDossa, Fahima, Nancy N. Baxter, Rinku Sutradhar, Tari Little, Lea Velsher, Jordan Lerner-Ellis, Andrea Eisen, and Kelly Metcalfe. 2025. "Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program" Current Oncology 32, no. 8: 439. https://doi.org/10.3390/curroncol32080439
APA StyleDossa, F., Baxter, N. N., Sutradhar, R., Little, T., Velsher, L., Lerner-Ellis, J., Eisen, A., & Metcalfe, K. (2025). Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program. Current Oncology, 32(8), 439. https://doi.org/10.3390/curroncol32080439