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Article

24 Citations

7,583 Views

15 Pages

Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones

Rui Xu,
Gang-Ming Xu,
Xiao-Ming Li,
Chun-Shun Li and
Bin-Gui Wang

Mar. Drugs2015, 13(11), 7040-7054;https://doi.org/10.3390/md13117040

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19 November 2015

The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite...

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Article

16 Citations

2,884 Views

16 Pages

Wentilactone A Reverses the NF-κB/ECM1 Signaling-Induced Cisplatin Resistance through Inhibition of IKK/IκB in Ovarian Cancer Cells

Cuiting Lv,
Chunxia Ren,
Yinjue Yu,
Huijing Yin,
Caiguo Huang,
Gong Yang and
Yang Hong

Nutrients2022, 14(18), 3790;https://doi.org/10.3390/nu14183790

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14 September 2022

Wentilactone A (WA) is a tetranorditerpenoid isolated from marine algae. We previously found that WA inhibited cancer cell proliferation with little toxicity. In this study, we show that high expression of extracellular matrix protein-1 (ECM1) promot...

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