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Open AccessArticle

Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones

by Rui Xu 1,2,†, Gang-Ming Xu 1,†, Xiao-Ming Li 1, Chun-Shun Li 1 and Bin-Gui Wang 1,*
1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Peer B. Jacobson
Mar. Drugs 2015, 13(11), 7040-7054; https://doi.org/10.3390/md13117040
Received: 27 September 2015 / Accepted: 13 November 2015 / Published: 19 November 2015
The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under static cultures with very low yields. In order to improve wentilactone production, culture conditions were optimized using the response surface methodology. Under the optimal static fermentation conditions, the experimental values were closely consistent with the prediction model. The yields of wentilactone A and B were increased about 11-fold to 13.4 and 6.5 mg/L, respectively. The result was further verified by fermentation scale-up for wentilactone production. Moreover, some small-molecule elicitors were found to have capacity of stimulating wentilactone production. To our knowledge, this is first report of optimized production of tetranorlabdane diterpenoids by a deep-sea derived marine fungus. The present study might be valuable for efficient production of wentilactones and fundamental investigation of the anti-tumor mechanism of norditerpenoids. View Full-Text
Keywords: Aspergillus dimorphicus; anti-tumor agent; wentilactones; optimization Aspergillus dimorphicus; anti-tumor agent; wentilactones; optimization
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Xu, R.; Xu, G.-M.; Li, X.-M.; Li, C.-S.; Wang, B.-G. Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones. Mar. Drugs 2015, 13, 7040-7054.

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