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1,182 Results Found

  • Article
  • Open Access
3 Citations
3,225 Views
21 Pages

1 October 2023

The Mohr–Coulomb (M-C) and Hoek–Brown (H-B) strength criteria are widely used in various engineering fields, such as mining engineering, tunnel engineering and so on. To investigate the M-C and H-B strength criteria considering the unload...

(This article belongs to the Special Issue Future Trends of Sustainable Rock Engineering)
  • Article
  • Open Access
50 Citations
5,151 Views
18 Pages

On the Kaiser Effect of Rock under Cyclic Loading and Unloading Conditions: Insights from Acoustic Emission Monitoring

  • Qingbin Meng,
  • Yanlong Chen,
  • Mingwei Zhang,
  • Lijun Han and ,
  • Hai Pu and
  • Jiangfeng Liu
  • + 1 author+ 0 author

23 August 2019

The Kaiser effect reflects the memory of the loaded rock to the irreversible damage and deformation. The stress level, loading rate and lithology are the main factors affecting the Kaiser effect of the rock. To identify the accurate stress point of t...

(This article belongs to the Special Issue Advanced Technologies for Energy Exploitation of Coals)
  • Article
  • Open Access
26 Citations
3,030 Views
19 Pages

15 May 2020

Aiming at the large deformation instability problem caused by the excavation unloading of a coal roadway in deep-buried slowly inclined jointed rock mass, the geomechanical parameters and deformation failure characteristics of an engineering geomecha...

  • Article
  • Open Access
3 Citations
1,986 Views
20 Pages

7 August 2024

Coal seam cavitation is one of the most effective techniques for gas disaster control in low-permeability coal. Due to the difference in cavitation method and process, the damage degree and fracture development range of the coal body around the caver...

(This article belongs to the Special Issue Monitoring, Process Control, Simulation, and Optimization in Coal Mining)
  • Article
  • Open Access
4 Citations
1,785 Views
18 Pages

Study on the Effect of High Temperature and Cyclic Loading and Unloading Methods on the Mechanical Properties of Granite

  • Fan Zhang,
  • Congcong Lv,
  • Kangwen Li,
  • Yiming Zhang and ,
  • Shengyuan Liu and
  • Man Li
  • + 1 author+ 0 author

17 April 2025

During the formation of deep rock bodies, such as hot dry rock, they are frequently exposed to high temperatures and repeated stress perturbations. The prolonged interaction of these two factors is a potential cause of deep underground rock instabili...

(This article belongs to the Special Issue Advances and Challenges in Rock Mechanics and Rock Engineering)
  • Article
  • Open Access
8 Citations
4,729 Views
30 Pages

The Destabilizing Effect of Glacial Unloading on a Large Volcanic Slope Instability in Southeast Iceland

  • Daniel Ben-Yehoshua,
  • Sigurður Erlingsson,
  • Þorsteinn Sæmundsson,
  • Reginald L. Hermanns and ,
  • Eyjólfur Magnússon,
  • Robert A. Askew and
  • Jóhann Helgason
  • + 2 authors+ 0 author

Since the turn of the 20th century, glacial thinning has been exposing volcanic mountain slopes around Iceland’s outlet glaciers. In the early 2000s, several slope instabilities appeared around the Svínafellsjökull outlet glacier in...

(This article belongs to the Special Issue Landslide Research: State of the Art and Innovations)
  • Article
  • Open Access
23 Citations
3,251 Views
20 Pages

The Effect of SERCA Activation on Functional Characteristics and Signaling of Rat Soleus Muscle upon 7 Days of Unloading

  • Kristina A. Sharlo,
  • Irina D. Lvova,
  • Sergey A. Tyganov,
  • Ksenia A. Zaripova and ,
  • Svetlana P. Belova,
  • Tatiana Y. Kostrominova,
  • Boris S. Shenkman and
  • Tatiana L. Nemirovskaya
  • + 3 authors+ 0 author

6 September 2023

Skeletal muscle abnormalities and atrophy during unloading are accompanied by the accumulation of excess calcium in the sarcoplasm. We hypothesized that calcium accumulation may occur, among other mechanisms, due to the inhibition of sarco/endoplasmi...

(This article belongs to the Section Molecular Medicine)
  • Article
  • Open Access
228 Views
18 Pages

The apparent unloading modulus of sheet metals decreases with plastic pre-strain, and its directional dependence may affect springback prediction. This study investigates its directional evolution in CN4301-4307+2B, DOCOL780DP+AM, and WBS235JR using...

  • Article
  • Open Access
10 Citations
3,269 Views
11 Pages

1 March 2023

To study the formation mechanism of the lower shaft resistance of uplift piles compared to compression piles, the additional stress caused by uplift and compressive piles in the soil is obtained through indoor model tests with embedded micro earth pr...

(This article belongs to the Section Civil Engineering)
  • Article
  • Open Access
19 Citations
3,928 Views
28 Pages

24 September 2021

The weakening effect is one of the most important causes triggering large deformation and failure of soft-rock engineering; however, few studies paid attention to damage evolution and constitutive relationship of rock in tensile damage in the excavat...

  • Article
  • Open Access
2,226 Views
15 Pages

17 September 2025

Under specific temperature and strain rate conditions, certain materials, such as low-carbon steels and select magnesium and aluminum alloys, experience a localized deformation phenomenon known as the Lüders effect. This behavior manifests as a...

  • Article
  • Open Access
28 Citations
4,317 Views
10 Pages

Effect of Microgravity on the Gut Microbiota Bacterial Composition in a Hindlimb Unloading Model

  • Ruqaiyyah Siddiqui,
  • Rizwan Qaisar,
  • Naveed Ahmed Khan,
  • Ahmad M. Alharbi and ,
  • Hasan Alfahemi and
  • Adel Elmoselhi
  • + 1 author+ 0 author

12 November 2022

We utilised a ground-based microgravity hindlimb unloading (HU) mouse model to elucidate the gut microbiota bacterial changes in mice under a simulated microgravity environment. Four-month-old, male C57/Bl6 mice were randomly divided into ground-base...

(This article belongs to the Special Issue The Space Environment on Human Health and Disease)
  • Article
  • Open Access
8 Citations
1,873 Views
19 Pages

This paper investigates the impact of surcharge/unloading at both sides of the ground surface on an existing underground shield tunnel at varying burial depths. A large-scale indoor model experiment was conducted to study the vertical convergence def...

(This article belongs to the Section Building Structures)
  • Article
  • Open Access
52 Citations
6,009 Views
26 Pages

Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models

  • Francesca Cialdai,
  • Alessandra Colciago,
  • Desiré Pantalone,
  • Angela Maria Rizzo and ,
  • Stefania Zava,
  • Lucia Morbidelli,
  • Fabio Celotti,
  • Daniele Bani and
  • Monica Monici
  • + 4 authors+ 0 author

Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reaso...

(This article belongs to the Special Issue Microgravity and Cell Adherence)
  • Article
  • Open Access
1 Citations
490 Views
20 Pages

Effect of Confining Pressure on the Damage Evolution Process of Coal with Boreholes Under Graded Cyclic Loading–Unloading

  • Xiaojing Feng,
  • Shutong Guo,
  • Dong Duan,
  • Weiheng Guo and ,
  • Zhiduo Fu and
  • Minggang Chang
  • + 1 author+ 0 author

8 May 2026

During underground mining, the stability of in-seam gas drainage boreholes is jointly affected by multiple factors, including the in situ stress state and borehole structure. Borehole instability can reduce gas drainage efficiency and increase underg...

(This article belongs to the Special Issue Sustainable Development of the Coal Industry: Process Safety and Environmental Protection)
  • Article
  • Open Access
5 Citations
2,982 Views
18 Pages

22 August 2022

The modeling of cyclic behavior in rock remains a challenge due to complex deformation characteristics. This paper studied the mechanical behaviors of granite samples under uniaxial cyclic loading and unloading through cyclic compression tests and ac...

(This article belongs to the Section Sustainable Engineering and Science)
  • Article
  • Open Access
35 Citations
3,478 Views
23 Pages

19 December 2019

In order to study the influence of advancing speed and stoping time of a coal face on the scale and frequency of rock burst, the energy release characteristics of an overburden fracture under six advancing speeds and four stoping times are studied by...

  • Article
  • Open Access
312 Views
26 Pages

Unloading Mechanical Behaviors of Clay Considering Initial Principal Stress Direction Effect: Experimental Study and Modified Constitutive Model

  • Ping Hu,
  • Wei-Xun Zhang,
  • Yi Han,
  • Xiang-Hua Song and ,
  • Le Zhang,
  • Jia-Yu Ruan and
  • Jun-Cheng Liu
  • + 2 authors+ 0 author

24 August 2026

Excavation-induced unloading can alter soil response through both stress-path effects and material orientation. This study investigates remolded clay from Jinan using conventional consolidated undrained (CCU) and lateral unloading undrained (LUU) tri...

(This article belongs to the Special Issue Testing of Materials and Elements in Civil Engineering (5th Edition))
  • Article
  • Open Access
2 Citations
2,823 Views
18 Pages

9 December 2022

In the seismic response analysis of liquefiable sites, the existing soil dynamic constitutive model is challenging to simulate saturated sand’s post-liquefaction deformation, and the current pore-water pressure buildup model cannot reflect the...

(This article belongs to the Special Issue Earthquake Engineering Technology and Its Application)
  • Proceeding Paper
  • Open Access
3 Citations
1,833 Views
6 Pages

Effect of Soil Loading and Unloading on Its Acoustic Behavior

  • Vladimir Frid,
  • Stelios M. Potirakis and
  • Semen Shulov

9 November 2020

The aim of the study was to understand the changes of ultrasound-wave speed (US) and acoustic emission (AE) as a result of soil loading and unloading. The soil was dune Sand, Poorly graded, i.e., “SP” according to the Unified Soil Classification Syst...

(This article belongs to the Proceedings of The 1st International Electronic Conference on Applied Sciences)
  • Article
  • Open Access
13 Citations
3,651 Views
25 Pages

Study on Disturbance Mechanism of Squeezed and Non-Squeezed Soil Piles on Soft Soil Foundation

  • Chengyuan Lin,
  • Ruyi Wang,
  • Mengshuang Huang,
  • Lebin Huang and
  • Qinwen Tan

30 June 2023

The construction process of pile foundations can significantly disrupt the soil. Therefore, it is necessary to limit the degree of soil disturbance caused by pile foundation construction to an acceptable level. This paper examines the disturbance eff...

(This article belongs to the Special Issue Advanced Numerical Simulations in Geotechnical Engineering II)
  • Article
  • Open Access
1 Citations
35 Views
37 Pages

Evaluating Compressibility Assumptions for Geological CO2 Storage Using Linear and Nonlinear Compression Evidence

  • Nuttapon Chaiduangsri,
  • Nopanom Kaewhanam,
  • Thammanun Chatwong,
  • Sudsakorn Inthidech and ,
  • Apichit Kampala,
  • Sitthiphat Eua-apiwatch and
  • Sivarit Sultornsanee
  • + 2 authors+ 0 author

7 November 2026

Pressure buildup in geological CO2 storage depends on how pore volume changes with effective stress, yet the laboratory evidence behind simulator compressibility inputs is often sparse. We test when a constant logarithmic compression slope is adequat...

(This article belongs to the Section H: Geo-Energy)
  • Article
  • Open Access
721 Views
18 Pages

30 December 2025

Traditional physical similarity simulation methods struggle to replicate the cumulative unloading–expansion effect in overburden, particularly due to inherent limitations in representing the bulking–compaction behavior of fractured rock m...

  • Article
  • Open Access
5 Citations
2,810 Views
19 Pages

Research on the Effects of Two-Sided Ground Surcharge/Unloading on Existing Shield Tunnels

  • Gang Wei,
  • Pengfei Xiang,
  • Haibo Jiang,
  • Di Sun and ,
  • Fengjun Xu and
  • Huifang Guo
  • + 1 author+ 0 author

6 December 2022

For the effect of two-sided sudden surcharge/unloading on existing shield tunnels, an indoor dimensional reduction model test was conducted at a scale of 1:15.5, measuring the ground settlement, lateral convergence of the shield tunnel, and additiona...

(This article belongs to the Section Civil Engineering)
  • Article
  • Open Access
4 Citations
1,834 Views
12 Pages

Percutaneous ventricular assist devices are utilized in cases of cardiogenic shock following acute myocardial infarction (AMI). However, the mechanism underlying the beneficial effects of LV unloading in AMI remains unclear. This study aimed to exami...

(This article belongs to the Special Issue Cardiovascular Diseases: Histopathological and Molecular Diagnostics)
  • Article
  • Open Access
2,244 Views
27 Pages

The mechanical behavior of rocks under loading conditions depends on stress path and magnitude. With increasing load, rocks have an elasto-plastic behavior. Within the loading yield surface, constitutive models assume that rocks behave elastically an...

(This article belongs to the Section Geomechanics)
  • Article
  • Open Access
12 Citations
3,826 Views
14 Pages

An Experimental Study on the Effects of True Triaxial Loading and Unloading Stress Paths on the Mechanical Properties of Red Sandstone

  • Shuai Wang,
  • Lianguo Wang,
  • Jiansheng Tian,
  • Hao Fan and ,
  • Chongyang Jiang and
  • Ke Ding
  • + 1 author+ 0 author

5 February 2022

Loading and unloading stress paths play critical roles in investigating the deformation and failure of roadway excavation. In this study, tests under four different loading and unloading stress paths were conducted on red sandstone samples, with the...

(This article belongs to the Special Issue Fracturing of Coal and Rock Mass)
  • Article
  • Open Access
7 Citations
3,075 Views
21 Pages

14 March 2023

After conducting true triaxial tests on sandstone in a laboratory setting, this study aims to determine the safe tunnelling rate of the roadway by examining the instability and failure characteristics of surrounding rock under different disturbance s...

(This article belongs to the Section Energy Sustainability)
  • Article
  • Open Access
1 Citations
2,165 Views
12 Pages

In this study, the response mechanism between macro- and microscales of deep hard-rock diorite is investigated under loading and unloading conditions. Moreover, the statistical theory is combined with particle flow code simulations to establish a cor...

(This article belongs to the Special Issue Construction in Urban Underground Space)
  • Article
  • Open Access
4 Citations
3,871 Views
13 Pages

13 January 2023

Timely and complete replication of the genome is essential for life. The PCNA ring plays an essential role in DNA replication and repair by contributing to the processivity of DNA polymerases and by recruiting proteins that act in DNA replication-ass...

(This article belongs to the Special Issue Nuclear Genome Stability: DNA Replication and DNA Repair)
  • Review
  • Open Access
3 Citations
1,878 Views
12 Pages

Continuous Use During Disuse: Mechanisms and Effects of Spontaneous Activity of Unloaded Postural Muscle

  • Boris S. Shenkman,
  • Vitaliy E. Kalashnikov,
  • Kristina A. Sharlo,
  • Olga V. Turtikova and ,
  • Roman O. Bokov and
  • Timur M. Mirzoev
  • + 1 author+ 0 author

20 November 2024

In most mammals, postural soleus muscles are involved in the maintenance of the stability of the body in the gravitational field of Earth. It is well established that immediately after a laboratory rat is exposed to conditions of weightlessness (para...

(This article belongs to the Special Issue Molecular Insight into Skeletal Muscle Atrophy and Regeneration)
  • Article
  • Open Access
661 Views
17 Pages

Effects of Body Weight Unloading and Treadmill Belt Surface on Tibial Acceleration-Based Loading Indicators During Running on a Microgravity Treadmill

  • Łukasz Oleksy,
  • Anna Mika,
  • Martyna Sopa,
  • Artur Stolarczyk and ,
  • Olga Adamska,
  • Maciej Kuchciak,
  • Miłosz Szczudło,
  • Paulina Ciepiela,
  • Rafał Buryta and
  • Renata Kielnar
  • + 6 authors+ 1 author

9 May 2026

Background/Objectives: The aim of this study was to compare tibial acceleration and acceleration-based indicators associated with tibial loading during running under full body weight (BW) conditions and with body weight support (80%, 60%, and 40% BW)...

(This article belongs to the Special Issue New Insights into Sports Injuries and Rehabilitation: From Injury to Performance)
  • Article
  • Open Access
8 Citations
3,829 Views
18 Pages

Quantifying Co-Deformation Effects in Metallic Laminates by Loading–Unloading–Reloading Tensile Tests

  • Philip Manuel Pohl,
  • Moritz Kuglstatter,
  • Mathias Göken and
  • Heinz Werner Höppel

30 May 2023

Heterostructured materials such as metallic laminates (LMCs) can be specifically tailored to showcase significantly increased mechanical behavior based on the hetero-deformation-induced (HDI) strengthening effect caused by the co-deformation at the v...

  • Communication
  • Open Access
7 Citations
3,212 Views
11 Pages

The purpose was to investigate the effect of load and fatigue on landing forces and mechanics. Thirteen Department of State special agents first completed drop jump testing, a maximal treadmill test, and another round of drop jump testing. During dro...

(This article belongs to the Special Issue Training for Optimal Sports Performance and Health)
  • Article
  • Open Access
9 Citations
2,177 Views
21 Pages

19 May 2024

A series of freeze–thaw cycling tests, as well as cyclic loading and unloading tests, have been conducted on nodular sandstones to investigate the effect of fatigue loading and freeze–thaw cycling on the damage evolution of fractured sand...

(This article belongs to the Special Issue Innovative Material Design and Nondestructive Testing Applications for Infrastructure Materials)
  • Article
  • Open Access
1 Citations
2,399 Views
28 Pages

31 October 2023

This paper addresses the flexible flow shop scheduling problem with unloading operations, which commonly occurs in modern manufacturing processes like sand casting. Although only a few related works have been proposed in the literature, the significa...

  • Article
  • Open Access
3 Citations
1,357 Views
49 Pages

31 October 2025

The aim of this work was to investigate the evolution of the mechanical integrity of the selected offshore oil reservoir during its life cycle. The geomechanical stability of the reservoir formation, including the caprock and base rock, was investiga...

(This article belongs to the Section B3: Carbon Emission and Utilization)
  • Article
  • Open Access
143 Views
23 Pages

Experimental and Inverse Analysis of Natural Cork Material with Anisotropic Nonlinear Viscoelastic Behavior

  • Cylia Yahiaoui,
  • Younès Saadallah,
  • Reza Afshar,
  • Kristofer Gamstedt and
  • B. Emek Abali

2 November 2026

Due to its cellular structure, cork from Quercus suber has significant deformability, showing magnificent recovery after being compressed by 50%. Its mechanical characteristics show dependency on the direction of the external load (anisotropy), makin...

(This article belongs to the Special Issue Advances in the Structure and Mechanical Properties of Polymer Composites)
  • Article
  • Open Access
4 Citations
2,067 Views
14 Pages

Laboratory Study of Effective Stress Coefficient for Saturated Claystone

  • Fanfan Li,
  • Weizhong Chen,
  • Zhigang Wu,
  • Hongdan Yu and ,
  • Ming Li,
  • Zhifeng Zhang and
  • Fusheng Zha
  • + 2 authors+ 0 author

22 September 2023

Claystone is potentially the main rock formation for the deep geological disposal of high-level radioactive nuclear waste. A major factor that affects the deformation of the host medium is effective stress. Therefore, studying the effective stress pr...

(This article belongs to the Special Issue Advanced Devices and Data Analysis in Vibration Control and Structural Health Monitoring)
  • Article
  • Open Access
3 Citations
2,112 Views
18 Pages

14 February 2023

Conventional and cyclic unloading tests with different unloading rates were conducted to study the influences of unloading patterns and rates on the deformation characteristics and mechanical properties of tectonic coal. The results demonstrate that,...

(This article belongs to the Section H1: Petroleum Engineering)
  • Article
  • Open Access
18 Citations
14,257 Views
24 Pages

An Evaluation Method of Brittleness Characteristics of Shale Based on the Unloading Experiment

  • Xiaogui Zhou,
  • Haiming Liu,
  • Yintong Guo,
  • Lei Wang and ,
  • Zhenkun Hou and
  • Peng Deng
  • + 1 author+ 0 author

10 May 2019

Shale reservoir has an initial unloading effect during the natural uplift and erosion process, which causes the shale brittleness to change, affecting the design of the fracturing scheme. To consider this, the axial compression loading and confining...

  • Article
  • Open Access
7 Citations
2,947 Views
20 Pages

Consolidated undrained triaxial shear tests were performed on undisturbed saturated structured clay at three unloading rates (0.1, 0.25, and 2.5 kPa/min) using a GDS triaxial system to determine the effects of different unloading rates and unloading...

(This article belongs to the Special Issue Geomechanics and Geotechnical Engineering Problems in the Design and Construction of Underground Buildings)
  • Article
  • Open Access
2 Citations
1,824 Views
20 Pages

11 November 2024

This paper utilizes the waste bunker of a waste incineration plant as the analysis model. It analyzes the airflow characteristics under various unloading door opening states and the air flow velocity through CFD simulation. The simulation analysis re...

(This article belongs to the Section Environmental and Green Processes)
  • Article
  • Open Access
2 Citations
1,775 Views
15 Pages

The Physical Behavior of Protected Coal Seams Based on Triaxial Unloading Conditions

  • Zhiheng Chen,
  • Junhua Xue,
  • Lanlan Guo,
  • Renhui Cheng and ,
  • Quanlin Yang and
  • Jian Xiao
  • + 1 author+ 0 author

22 January 2024

Protective seam mining is the most economical and effective measure for eliminating coal and gas herniation. To study the unloading effect of the mining of a protective seam on the protected layer, and to better grasp the effect of the protective lay...

(This article belongs to the Special Issue Prevention and Control of Coal Mine Gas Disasters)
  • Article
  • Open Access
11 Citations
3,437 Views
18 Pages

13 July 2023

Rubber composites are hyperelastic materials with obvious stress-softening effects during the cyclic loading–unloading process. In previous studies, it is hard to obtain the stress responses of rubber composites at arbitrary loading–unloa...

(This article belongs to the Topic Advanced Polymeric Composites: Processing, Characterization and Mechanical Behavior)
  • Article
  • Open Access
655 Views
19 Pages

Creep Mechanical Properties of Marble Under Graded Unloading Conditions

  • Yongcheng Guo,
  • Zhuo Yu,
  • Shunan Wang,
  • Jianlin Li and
  • Huafeng Deng

29 March 2026

To study the creep mechanical behavior of surrounding rock under the coupled effect of confining pressure unloading and deviatoric stress increase during the excavation of deep underground engineering, triaxial creep tests under stepwise unloading of...

(This article belongs to the Special Issue Advances in Rock Excavation and Underground Construction Technology)
  • Article
  • Open Access
8 Citations
2,920 Views
19 Pages

Mechanical Strength Decay Evaluation of Excavation Unloaded Rock Mass under Freeze-Thaw Conditions

  • Xingzhou Chen,
  • Wei Du,
  • Lili Chen,
  • Bin Ma and ,
  • Sheng Gong,
  • Hai Jiang and
  • Wenrui Wang
  • + 2 authors+ 0 author

29 November 2022

The quality of excavated and unloaded rock masses on steep and high slopes in cold regions is prone to deterioration, which in turn affects the long-term stability and safety of excavated slopes. Based on a triaxial unloading-damage test of sandstone...

(This article belongs to the Special Issue Research on Rock Mechanics and Backfilling Materials for Underground Mining)
  • Article
  • Open Access
1 Citations
2,991 Views
16 Pages

Effect of Dynamic Bridging on Homogeneous Grain Movement in a Microwave Processing Zone

  • Alexey A. Vasilyev,
  • Alexey N. Vasilyev,
  • Dmitry Budnikov,
  • Vadim Bolshev and ,
  • Michal Jasinski,
  • Zbigniew Leonowicz,
  • Radomir Gono and
  • Lukasz Jasinski
  • + 3 authors+ 0 author

7 October 2021

This article describes the influence of dynamic bridging in the unloading of a hopper at a processing plant on the grain flow homogeneity in a convective-microwave zone. In accordance with calculation methods for unloading hoppers, the parameters of...

(This article belongs to the Special Issue Innovative Technologies in Crop Production and Animal Husbandry)
  • Article
  • Open Access
1 Citations
366 Views
20 Pages

Influences of Internal Unloading and Lateral Stress on Rockburst Behavior in Deep Hard Rock Roadways

  • Xuefeng Si,
  • Yankun Ma,
  • Zilong Zhang,
  • Bo Meng and ,
  • Qiucai Zhang,
  • Song Luo and
  • Yong Luo
  • + 2 authors+ 0 author

27 June 2026

To explore the effects of internal unloading and lateral stress on rockburst behavior in deep hard rock roadways, rockburst simulation tests were executed utilizing a self-developed internal unloading apparatus. A miniature camera was employed to mon...

  • Article
  • Open Access
21 Citations
6,336 Views
14 Pages

Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity

  • John M. Lawler,
  • Jeffrey M. Hord,
  • Pat Ryan,
  • Dylan Holly and ,
  • Mariana Janini Gomes,
  • Dinah Rodriguez,
  • Vinicius Guzzoni,
  • Erika Garcia-Villatoro,
  • Chase Green and
  • Khaled Y. Kamal
  • + 13 authors+ 8 authors

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle atrophy during mechanical unloading (e.g., spaceflight and bedrest). Perturbations in heat shock proteins (e.g., HSP70), antioxidant enzymes, and sarcolemmal...

(This article belongs to the Special Issue Microgravity and Space Medicine)

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