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969 Results Found

  • Article
  • Open Access
2 Citations
2,450 Views
21 Pages

1 October 2023

The Mohr–Coulomb (M-C) and Hoek–Brown (H-B) strength criteria are widely used in various engineering fields, such as mining engineering, tunnel engineering and so on. To investigate the M-C and H-B strength criteria considering the unload...

  • Article
  • Open Access
45 Citations
4,527 Views
18 Pages

23 August 2019

The Kaiser effect reflects the memory of the loaded rock to the irreversible damage and deformation. The stress level, loading rate and lithology are the main factors affecting the Kaiser effect of the rock. To identify the accurate stress point of t...

  • Article
  • Open Access
22 Citations
2,722 Views
19 Pages

15 May 2020

Aiming at the large deformation instability problem caused by the excavation unloading of a coal roadway in deep-buried slowly inclined jointed rock mass, the geomechanical parameters and deformation failure characteristics of an engineering geomecha...

  • Article
  • Open Access
2 Citations
1,572 Views
20 Pages

7 August 2024

Coal seam cavitation is one of the most effective techniques for gas disaster control in low-permeability coal. Due to the difference in cavitation method and process, the damage degree and fracture development range of the coal body around the caver...

  • Article
  • Open Access
1 Citations
1,155 Views
18 Pages

17 April 2025

During the formation of deep rock bodies, such as hot dry rock, they are frequently exposed to high temperatures and repeated stress perturbations. The prolonged interaction of these two factors is a potential cause of deep underground rock instabili...

  • Article
  • Open Access
1 Citations
3,190 Views
30 Pages

The Destabilizing Effect of Glacial Unloading on a Large Volcanic Slope Instability in Southeast Iceland

  • Daniel Ben-Yehoshua,
  • Sigurður Erlingsson,
  • Þorsteinn Sæmundsson,
  • Reginald L. Hermanns,
  • Eyjólfur Magnússon,
  • Robert A. Askew and
  • Jóhann Helgason

Since the turn of the 20th century, glacial thinning has been exposing volcanic mountain slopes around Iceland’s outlet glaciers. In the early 2000s, several slope instabilities appeared around the Svínafellsjökull outlet glacier in...

  • Article
  • Open Access
16 Citations
2,722 Views
20 Pages

The Effect of SERCA Activation on Functional Characteristics and Signaling of Rat Soleus Muscle upon 7 Days of Unloading

  • Kristina A. Sharlo,
  • Irina D. Lvova,
  • Sergey A. Tyganov,
  • Ksenia A. Zaripova,
  • Svetlana P. Belova,
  • Tatiana Y. Kostrominova,
  • Boris S. Shenkman and
  • Tatiana L. Nemirovskaya

6 September 2023

Skeletal muscle abnormalities and atrophy during unloading are accompanied by the accumulation of excess calcium in the sarcoplasm. We hypothesized that calcium accumulation may occur, among other mechanisms, due to the inhibition of sarco/endoplasmi...

  • Article
  • Open Access
8 Citations
2,719 Views
11 Pages

1 March 2023

To study the formation mechanism of the lower shaft resistance of uplift piles compared to compression piles, the additional stress caused by uplift and compressive piles in the soil is obtained through indoor model tests with embedded micro earth pr...

  • Article
  • Open Access
17 Citations
3,379 Views
28 Pages

24 September 2021

The weakening effect is one of the most important causes triggering large deformation and failure of soft-rock engineering; however, few studies paid attention to damage evolution and constitutive relationship of rock in tensile damage in the excavat...

  • Article
  • Open Access
1,087 Views
15 Pages

17 September 2025

Under specific temperature and strain rate conditions, certain materials, such as low-carbon steels and select magnesium and aluminum alloys, experience a localized deformation phenomenon known as the Lüders effect. This behavior manifests as a...

  • Article
  • Open Access
16 Citations
3,759 Views
10 Pages

Effect of Microgravity on the Gut Microbiota Bacterial Composition in a Hindlimb Unloading Model

  • Ruqaiyyah Siddiqui,
  • Rizwan Qaisar,
  • Naveed Ahmed Khan,
  • Ahmad M. Alharbi,
  • Hasan Alfahemi and
  • Adel Elmoselhi

12 November 2022

We utilised a ground-based microgravity hindlimb unloading (HU) mouse model to elucidate the gut microbiota bacterial changes in mice under a simulated microgravity environment. Four-month-old, male C57/Bl6 mice were randomly divided into ground-base...

  • Article
  • Open Access
4 Citations
1,490 Views
19 Pages

This paper investigates the impact of surcharge/unloading at both sides of the ground surface on an existing underground shield tunnel at varying burial depths. A large-scale indoor model experiment was conducted to study the vertical convergence def...

  • Article
  • Open Access
41 Citations
5,640 Views
26 Pages

Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models

  • Francesca Cialdai,
  • Alessandra Colciago,
  • Desiré Pantalone,
  • Angela Maria Rizzo,
  • Stefania Zava,
  • Lucia Morbidelli,
  • Fabio Celotti,
  • Daniele Bani and
  • Monica Monici

Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reaso...

  • Article
  • Open Access
5 Citations
2,328 Views
18 Pages

22 August 2022

The modeling of cyclic behavior in rock remains a challenge due to complex deformation characteristics. This paper studied the mechanical behaviors of granite samples under uniaxial cyclic loading and unloading through cyclic compression tests and ac...

  • Article
  • Open Access
31 Citations
3,124 Views
23 Pages

19 December 2019

In order to study the influence of advancing speed and stoping time of a coal face on the scale and frequency of rock burst, the energy release characteristics of an overburden fracture under six advancing speeds and four stoping times are studied by...

  • Article
  • Open Access
2 Citations
2,424 Views
18 Pages

9 December 2022

In the seismic response analysis of liquefiable sites, the existing soil dynamic constitutive model is challenging to simulate saturated sand’s post-liquefaction deformation, and the current pore-water pressure buildup model cannot reflect the...

  • Proceeding Paper
  • Open Access
2 Citations
1,613 Views
6 Pages

Effect of Soil Loading and Unloading on Its Acoustic Behavior

  • Vladimir Frid,
  • Stelios M. Potirakis and
  • Semen Shulov

9 November 2020

The aim of the study was to understand the changes of ultrasound-wave speed (US) and acoustic emission (AE) as a result of soil loading and unloading. The soil was dune Sand, Poorly graded, i.e., “SP” according to the Unified Soil Classification Syst...

  • Article
  • Open Access
8 Citations
2,938 Views
25 Pages

Study on Disturbance Mechanism of Squeezed and Non-Squeezed Soil Piles on Soft Soil Foundation

  • Chengyuan Lin,
  • Ruyi Wang,
  • Mengshuang Huang,
  • Lebin Huang and
  • Qinwen Tan

30 June 2023

The construction process of pile foundations can significantly disrupt the soil. Therefore, it is necessary to limit the degree of soil disturbance caused by pile foundation construction to an acceptable level. This paper examines the disturbance eff...

  • Article
  • Open Access
251 Views
18 Pages

30 December 2025

Traditional physical similarity simulation methods struggle to replicate the cumulative unloading–expansion effect in overburden, particularly due to inherent limitations in representing the bulking–compaction behavior of fractured rock m...

  • Article
  • Open Access
4 Citations
2,258 Views
19 Pages

Research on the Effects of Two-Sided Ground Surcharge/Unloading on Existing Shield Tunnels

  • Gang Wei,
  • Pengfei Xiang,
  • Haibo Jiang,
  • Di Sun,
  • Fengjun Xu and
  • Huifang Guo

6 December 2022

For the effect of two-sided sudden surcharge/unloading on existing shield tunnels, an indoor dimensional reduction model test was conducted at a scale of 1:15.5, measuring the ground settlement, lateral convergence of the shield tunnel, and additiona...

  • Article
  • Open Access
1 Citations
1,325 Views
12 Pages

Percutaneous ventricular assist devices are utilized in cases of cardiogenic shock following acute myocardial infarction (AMI). However, the mechanism underlying the beneficial effects of LV unloading in AMI remains unclear. This study aimed to exami...

  • Article
  • Open Access
899 Views
27 Pages

The mechanical behavior of rocks under loading conditions depends on stress path and magnitude. With increasing load, rocks have an elasto-plastic behavior. Within the loading yield surface, constitutive models assume that rocks behave elastically an...

  • Article
  • Open Access
11 Citations
3,221 Views
14 Pages

5 February 2022

Loading and unloading stress paths play critical roles in investigating the deformation and failure of roadway excavation. In this study, tests under four different loading and unloading stress paths were conducted on red sandstone samples, with the...

  • Article
  • Open Access
4 Citations
2,483 Views
21 Pages

14 March 2023

After conducting true triaxial tests on sandstone in a laboratory setting, this study aims to determine the safe tunnelling rate of the roadway by examining the instability and failure characteristics of surrounding rock under different disturbance s...

  • Article
  • Open Access
1,601 Views
12 Pages

In this study, the response mechanism between macro- and microscales of deep hard-rock diorite is investigated under loading and unloading conditions. Moreover, the statistical theory is combined with particle flow code simulations to establish a cor...

  • Article
  • Open Access
3 Citations
3,496 Views
13 Pages

13 January 2023

Timely and complete replication of the genome is essential for life. The PCNA ring plays an essential role in DNA replication and repair by contributing to the processivity of DNA polymerases and by recruiting proteins that act in DNA replication-ass...

  • Review
  • Open Access
2 Citations
1,421 Views
12 Pages

Continuous Use During Disuse: Mechanisms and Effects of Spontaneous Activity of Unloaded Postural Muscle

  • Boris S. Shenkman,
  • Vitaliy E. Kalashnikov,
  • Kristina A. Sharlo,
  • Olga V. Turtikova,
  • Roman O. Bokov and
  • Timur M. Mirzoev

20 November 2024

In most mammals, postural soleus muscles are involved in the maintenance of the stability of the body in the gravitational field of Earth. It is well established that immediately after a laboratory rat is exposed to conditions of weightlessness (para...

  • Article
  • Open Access
7 Citations
3,155 Views
18 Pages

Quantifying Co-Deformation Effects in Metallic Laminates by Loading–Unloading–Reloading Tensile Tests

  • Philip Manuel Pohl,
  • Moritz Kuglstatter,
  • Mathias Göken and
  • Heinz Werner Höppel

30 May 2023

Heterostructured materials such as metallic laminates (LMCs) can be specifically tailored to showcase significantly increased mechanical behavior based on the hetero-deformation-induced (HDI) strengthening effect caused by the co-deformation at the v...

  • Communication
  • Open Access
5 Citations
2,903 Views
11 Pages

The purpose was to investigate the effect of load and fatigue on landing forces and mechanics. Thirteen Department of State special agents first completed drop jump testing, a maximal treadmill test, and another round of drop jump testing. During dro...

  • Article
  • Open Access
6 Citations
1,657 Views
21 Pages

19 May 2024

A series of freeze–thaw cycling tests, as well as cyclic loading and unloading tests, have been conducted on nodular sandstones to investigate the effect of fatigue loading and freeze–thaw cycling on the damage evolution of fractured sand...

  • Article
  • Open Access
1,984 Views
28 Pages

31 October 2023

This paper addresses the flexible flow shop scheduling problem with unloading operations, which commonly occurs in modern manufacturing processes like sand casting. Although only a few related works have been proposed in the literature, the significa...

  • Article
  • Open Access
666 Views
49 Pages

31 October 2025

The aim of this work was to investigate the evolution of the mechanical integrity of the selected offshore oil reservoir during its life cycle. The geomechanical stability of the reservoir formation, including the caprock and base rock, was investiga...

  • Article
  • Open Access
4 Citations
1,790 Views
14 Pages

Laboratory Study of Effective Stress Coefficient for Saturated Claystone

  • Fanfan Li,
  • Weizhong Chen,
  • Zhigang Wu,
  • Hongdan Yu,
  • Ming Li,
  • Zhifeng Zhang and
  • Fusheng Zha

22 September 2023

Claystone is potentially the main rock formation for the deep geological disposal of high-level radioactive nuclear waste. A major factor that affects the deformation of the host medium is effective stress. Therefore, studying the effective stress pr...

  • Article
  • Open Access
2 Citations
1,811 Views
18 Pages

14 February 2023

Conventional and cyclic unloading tests with different unloading rates were conducted to study the influences of unloading patterns and rates on the deformation characteristics and mechanical properties of tectonic coal. The results demonstrate that,...

  • Article
  • Open Access
17 Citations
13,813 Views
24 Pages

An Evaluation Method of Brittleness Characteristics of Shale Based on the Unloading Experiment

  • Xiaogui Zhou,
  • Haiming Liu,
  • Yintong Guo,
  • Lei Wang,
  • Zhenkun Hou and
  • Peng Deng

10 May 2019

Shale reservoir has an initial unloading effect during the natural uplift and erosion process, which causes the shale brittleness to change, affecting the design of the fracturing scheme. To consider this, the axial compression loading and confining...

  • Article
  • Open Access
4 Citations
2,437 Views
20 Pages

Consolidated undrained triaxial shear tests were performed on undisturbed saturated structured clay at three unloading rates (0.1, 0.25, and 2.5 kPa/min) using a GDS triaxial system to determine the effects of different unloading rates and unloading...

  • Article
  • Open Access
1 Citations
1,405 Views
20 Pages

11 November 2024

This paper utilizes the waste bunker of a waste incineration plant as the analysis model. It analyzes the airflow characteristics under various unloading door opening states and the air flow velocity through CFD simulation. The simulation analysis re...

  • Article
  • Open Access
1 Citations
1,423 Views
15 Pages

The Physical Behavior of Protected Coal Seams Based on Triaxial Unloading Conditions

  • Zhiheng Chen,
  • Junhua Xue,
  • Lanlan Guo,
  • Renhui Cheng,
  • Quanlin Yang and
  • Jian Xiao

22 January 2024

Protective seam mining is the most economical and effective measure for eliminating coal and gas herniation. To study the unloading effect of the mining of a protective seam on the protected layer, and to better grasp the effect of the protective lay...

  • Article
  • Open Access
8 Citations
2,764 Views
18 Pages

13 July 2023

Rubber composites are hyperelastic materials with obvious stress-softening effects during the cyclic loading–unloading process. In previous studies, it is hard to obtain the stress responses of rubber composites at arbitrary loading–unloa...

  • Article
  • Open Access
7 Citations
2,461 Views
19 Pages

Mechanical Strength Decay Evaluation of Excavation Unloaded Rock Mass under Freeze-Thaw Conditions

  • Xingzhou Chen,
  • Wei Du,
  • Lili Chen,
  • Bin Ma,
  • Sheng Gong,
  • Hai Jiang and
  • Wenrui Wang

29 November 2022

The quality of excavated and unloaded rock masses on steep and high slopes in cold regions is prone to deterioration, which in turn affects the long-term stability and safety of excavated slopes. Based on a triaxial unloading-damage test of sandstone...

  • Article
  • Open Access
1 Citations
2,590 Views
16 Pages

Effect of Dynamic Bridging on Homogeneous Grain Movement in a Microwave Processing Zone

  • Alexey A. Vasilyev,
  • Alexey N. Vasilyev,
  • Dmitry Budnikov,
  • Vadim Bolshev,
  • Michal Jasinski,
  • Zbigniew Leonowicz,
  • Radomir Gono and
  • Lukasz Jasinski

7 October 2021

This article describes the influence of dynamic bridging in the unloading of a hopper at a processing plant on the grain flow homogeneity in a convective-microwave zone. In accordance with calculation methods for unloading hoppers, the parameters of...

  • Article
  • Open Access
19 Citations
5,823 Views
14 Pages

Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity

  • John M. Lawler,
  • Jeffrey M. Hord,
  • Pat Ryan,
  • Dylan Holly,
  • Mariana Janini Gomes,
  • Dinah Rodriguez,
  • Vinicius Guzzoni,
  • Erika Garcia-Villatoro,
  • Chase Green and
  • Khaled Y. Kamal
  • + 8 authors

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle atrophy during mechanical unloading (e.g., spaceflight and bedrest). Perturbations in heat shock proteins (e.g., HSP70), antioxidant enzymes, and sarcolemmal...

  • Article
  • Open Access
1 Citations
533 Views
21 Pages

5 November 2025

To investigate the seepage and deformation failure characteristics of deep unloaded rock mass under cyclic loading and unloading disturbance, a series of triaxial cyclic loading and unloading tests were conducted on granite. These tests were performe...

  • Article
  • Open Access
16 Citations
2,343 Views
19 Pages

The optimization of film-unloading and film–soil separation components can effectively improve the residual film unloading rate and reduce impurity content. So, the DEM models of soil and residual film were established and the suspension and fl...

  • Article
  • Open Access
16 Citations
3,983 Views
21 Pages

Molecular and Metabolic Mechanism of Low-Intensity Pulsed Ultrasound Improving Muscle Atrophy in Hindlimb Unloading Rats

  • Lijun Sun,
  • Shasha An,
  • Zhihao Zhang,
  • Yaling Zhou,
  • Yanan Yu,
  • Zhanke Ma,
  • Xiushan Fan,
  • Liang Tang and
  • Jianzhong Guo

9 November 2021

Low-intensity pulsed ultrasound (LIPUS) has been proved to promote the proliferation of myoblast C2C12. However, whether LIPUS can effectively prevent muscle atrophy has not been clarified, and if so, what is the possible mechanism. The aim of this s...

  • Article
  • Open Access
1 Citations
2,254 Views
14 Pages

5 April 2022

The unclear understanding of the mechanical behavior of soil under unloading conditions is a significant reason for the frequent occurrence of accidents and difficulties in the deformation control of foundation pit engineering in coastal areas. This...

  • Article
  • Open Access
3 Citations
2,172 Views
16 Pages

3 March 2023

The creep associated with unloading surrounding rock during the excavation of deep tunnels seriously affects the stability of the tunnel, and a high seepage pressure will aggravate the strength attenuation and structural deterioration of the surround...

  • Article
  • Open Access
2 Citations
2,023 Views
17 Pages

12 January 2024

To address loading and unloading issues in civil and hydraulic engineering projects that employ coarse-grained soil as fill material under plane strain conditions during construction and operation, cyclic loading–unloading large-scale plane str...

  • Article
  • Open Access
4 Citations
2,967 Views
29 Pages

3 June 2020

3-D particle-based discrete element method (PB-DEM) was employed to numerically study the mechanical and progressive failure characteristics of pre-fissured marble specimens under conventional triaxial unloading conditions. The microscopic parameters...

  • Article
  • Open Access
4 Citations
1,929 Views
12 Pages

20 November 2022

The paper represents a test investigation of the mechanical properties and acoustic emission (AE) characteristics of low-strength coal specimens subjected to cyclic loading and unloading. From the lab tests, the following conclusions can be obtained:...

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