Search Results (825)

With the development of inspection robot control technology, wheel-legged robots are increasingly used in complex underground space inspection. To address low stability during obstacle crossing in unstructured terrains, a motion control strategy integrating an improved CPG algorithm and a biological reflex mechanism is proposed. It introduces an adaptive coupling matrix, augmented with the Lyapunov function, and vestibular/stumbling reflex models for real-time motion feedback. Simulink–Adams virtual prototypes and single-wheeled leg experiments (on the left front leg) were used to verify the system. Results show that the robot’s turning oscillation was ≤±0.00593 m, the 10° tilt maintained a stable center of mass at 10.2° with roll angle fluctuations ≤±5°, gully-crossing fluctuations ≤±0.01 m, and pitch recovery ≤2 s. The experiments aligned with the simulations, proving that the strategy effectively suppresses vertical vibrations, ensuring stable and high-precision inspection. Full article

Analysis of the EPR of dilute transition-ion complexes and metalloproteins in random phases, such as frozen solutions, powders, glasses, and gels, requires a model for the spectral ‘powder’ shape. Such a model comprises a description of the line shape and the linewidth of individual molecules as well as a notion of their physical origin. Spectral features sharpen up with decreasing temperature until the limit of constant linewidth of inhomogeneous broadening. At and below this temperature limit, each molecule has a linewidth that slightly differs from those of its congeners, and which is not related in a simple way to lifetime broadening. Choice of the model not only affects precise assignment of g-values, but also concentration determination (‘spin counting’), and therefore, calculation of stoichiometries in multi-center complexes. Forty years ago, the theoretically and experimentally well-founded statistical theory of g-strain was developed as a prime model for EPR powder patterns. In the intervening years until today, this model was universally ignored in favor of models that are incompatible with physical reality, resulting in many mistakes in EPR spectral interpretation. The purpose of this review is to outline the differences between the models, to reveal where analyses went astray, and thus to turn a very long standstill in EPR powder shape understanding into a new start towards proper methodology. Full article

This research compares speech discrimination abilities between 17 children who are hard-of-hearing (CHH) and 13 children with normal hearing (CNH), aged 9 to 36 months, using either a conditioned head turn (CHT) or condition play paradigm, for two phoneme pairs /ba-da/ and /sa-ʃa/. As CHH were tested in the aided and unaided conditions, CNH were also tested on each phoneme contrast twice to control for learning effects. When speech discrimination abilities were compared between CHH, with hearing aids (HAs), and CNH, there were no statistical differences observed in performance on stop consonant discrimination, but a significant statistical difference was observed for fricative discrimination performance. Among CHH, significant benefits were observed for /ba-da/ speech discrimination while wearing HAs, compared to the no HA condition. All CHH were early-identified, early amplified, and were enrolled in parent-centered early intervention services. Under these conditions, CHH demonstrated the ability to discriminate speech comparable to CNH. Additionally, repeated testing within 1-month did not result in a change in speech discrimination scores, indicating good test–retest reliability of speech discrimination scores. Finally, this research explored the question of infant/toddler listening fatigue in the behavioral speech discrimination task. The CHT paradigm included returning to a contrast (i.e., /a-i/) previously shown to be easier for both CHH and CNH to discriminate to examine if failure to discriminate /ba-da/ or /sa-ʃa/ was due to listening fatigue or off-task behavior. Full article

Introduction: Cystic fibrosis (CF) is a genetic condition affecting several organs and systems, including the pancreas, colon, respiratory system, and reproductive system. The detection of a growing number of CFTR variants and genotypes has contributed to an increase in the CF population which, in turn, has had an impact on the overall statistics regarding the prognosis and outcome of the condition. Given the increase in life expectancy, it is critical to better predict outcomes and prognosticate in CF. Thus, each person’s choice to aggressively treat specific disease components can be more appropriate and tailored, further increasing survival. The objective of our narrative review is to summarize the most recent information concerning the value and significance of clinical parameters in predicting outcomes, such as gender, diabetes, liver and pancreatic status, lung function, radiography, bacteriology, and blood and sputum biomarkers of inflammation and disease, and how variations in these parameters affect prognosis from the prenatal stage to maturity. Materials and methods: A methodological search of the available data was performed with regard to prognostic factors in the evolution of CF in children and young adults. We evaluated articles from the PubMed academic search engine using the following search terms: prognostic factors AND children AND cystic fibrosis OR mucoviscidosis. Results: We found that it is crucial to customize CF patients’ care based on their unique clinical and biological parameters, genetics, and related comorbidities. Conclusions: The predictive significance of more dynamic clinical condition markers provides more realistic future objectives to center treatment and targets for each patient. Over the past ten years, improvements in care, diagnostics, and treatment have impacted the prognosis for CF. Although genotyping offers a way to categorize CF to direct research and treatment, it is crucial to understand that a variety of other factors, such as epigenetics, genetic modifiers, environmental factors, and socioeconomic status, can affect CF outcomes. The long-term management of this complicated multisystem condition has been made easier for patients, their families, and physicians by earlier and more accurate identification techniques, evidence-based research, and centralized expert multidisciplinary care. Full article

The Sonora Estuarine Biocultural Corridor (CBES) is made up of six coastal wetlands with mangrove forest, internationally certified as Ramsar Sites. Four are part of indigenous territories whose inhabitants have serious development lags and low water security. Five are within one or more of six irrigation districts of national relevance. The objective is to learn about the socio-environmental problems of the CBES, focused on the issue of water, as well as community proposals for solutions. Intercultural, mixed methodology approach. Prospecting visits were carried out in the six estuaries of the CBES, and 84 semi-structured interviews were conducted with experts from all social sectors who know the problems of the CBES in three (out of six) estuaries associated with indigenous territories. The main problem is centered on the issue of water: they receive contaminated water from agroindustry, aquaculture, and the municipal service; the fresh water of the rivers is almost nil, rainfall has decreased while the heat increases, and marine and terrestrial biodiversity decreases. This affects the food and economic security of the local population and generates conflicts between the different productive activities. A multisectoral organization that integrates the six estuaries would improve community wellbeing and, in turn, climate resilience. Full article

This article presents an initial effort to systematize two interrelated research fronts within ecological economics (EE): ecological microeconomics and ecological macroeconomics. In response to the field’s transdisciplinary and plural nature—attributes that, while enriching, may limit its political influence—the article proposes a conceptual delineation of these two domains as a means to strengthen EE’s analytical identity and facilitate dialogue with other economic approaches. Ecological microeconomics focuses on the material and energy intensity of economic activity, the complementarity of natural capital in production processes, and the redesign of consumption and firm behavior under ecological constraints. Ecological macroeconomics, in turn, centers on the biophysical limits to growth, the concept of sustainable and optimal scale, and the integration of environmental variables into macroeconomic indicators and policy frameworks. The article argues that both fronts, despite their distinct emphases, are united by the need for long-term structural change and a normative commitment to sustainability. Together, they offer a coherent basis for rethinking prosperity within the ecological boundaries of the Earth system. Full article

Part I of this two-part documentation of the ECMWF ensemble (ECEPS) new tropical cyclone track and intensity forecasting challenges during the 2024 western North Pacific season described four typhoons that started well to the south of an unfavorable external environment north of 20° N. In this Part II, five other 2024 season typhoons that formed and intensified near and north of 20° N are documented. One change is that the Cooperative Institute for Meteorological Satellite Studies ADT + AIDT intensities derived from the Himawari-9 satellite were utilized for initialization and validation of the ECEPS intensity forecasts. Our first objective of providing earlier track and intensity forecast guidance than the Joint Typhoon Warning Center (JTWC) five-day forecasts was achieved for all five typhoons, although the track forecast spread was large for the early forecasts. For Marie (06 W) and Ampil (08 W) that formed near 25° N, 140° E in the middle of the unfavorable external environment, the ECEPS intensity forecasts accurately predicted the ADT + AIDT intensities with the exception that the rapid intensification of Ampil over the Kuroshio ocean current was underpredicted. Shanshan (11 W) was a challenging forecast as it intensified to a typhoon while being quasi-stationary near 17° N, 142° E before turning to the north to cross 20° N into the unfavorable external environment. While the ECEPS provided accurate guidance as to the timing and the longitude of the 20° N crossing, the later recurvature near Japan timing was a day early and 4 degrees longitude to the east. The ECEPS provided early, accurate track forecasts of Jebi’s (19 W) threat to mainland Japan. However, the ECEPS was predicting extratropical transition with V_max ~35 kt when the JTWC was interpreting Jebi’s remnants as a tropical cyclone. The ECEPS predicted well the unusual southward track of Krathon (20 W) out of the unfavorable environment to intensify while quasi-stationary near 18.5° N, 125.6° E. However, the rapid intensification as Krathon moved westward along 20° N was underpredicted. Full article

Energy is at the center of economic growth and environmental sustainability. Increasing energy efficiency and turning to environmentally friendly technologies are indispensable elements not only in reducing carbon emissions but also in supporting the transition to a green future. This study aims to deeply examine the simultaneous dynamic interactions between energy, environmental technologies, and economic growth by focusing on the environment and analyzing the transformative effects of these factors on environmental sustainability from a broad perspective. The models were estimated via simultaneous equation systems with two-stage and three-stage least squares methods with monthly data for Organization for Economic Cooperation and Development (OECD) countries between 1990 and 2021. As a result of the analyses, the estimation results of the two methods generally support each other. Notably, economic growth causes carbon emissions, and when tax revenues on energy are added to the model, the negative effect of economic growth on carbon emissions turns positive. Another significant result shows that energy efficiency does not reduce carbon emissions. Even an increase in energy efficiency causes an increase in carbon emissions, and the rebound effect is valid. Population and energy density do not have a negative impact on carbon emissions. Full article

Balance control in pirouettes has previously been characterized by constraint of the topple angle. However, there is a paucity of research using the margin of stability (MoS) as a dynamic measure of balance related to pirouettes. Therefore, this study aimed primarily to examine the MoS as a metric of balance during a single-turn en dehors pirouette in healthy female amateur ballet dancers. Four participants performed pirouettes until five successful pirouettes were achieved without hopping or loss of balance. Three-dimensional motion capture was used to record the motion trajectories of anatomical markers based on the Plug-in-Gait and Oxford Foot models. Motion synchronized with ground reaction forces was used to calculate the center of pressure (CoP), base of support (BoS), center of the pivot foot, center of mass (CoM), and extrapolated center of mass (XCoM) throughout the turn phase, using laboratory (LCS) and virtual left foot (LFT) coordinate systems. In the LCS and LFT coordinate system, the excursions and patterns of motion of both the CoM and XCoM relative to the CoP were similar, suggesting a neurological relationship. Two different measures of the margin of stability (MoS) in the LFT coordinate system were tabulated: the distance between the (1) XCoM and CoP and (2) XCoM and BoS center. The magnitude of both versions of the MoS was greatest at turn initiation and toe-touch, which was associated with two foot contacts. The MoS values were at a minimum approximately 50% of the stance during the turn phase: close to zero along the anteroposterior (A/P) axis and approximately 50 mm along the mediolateral (M/L) axis. On average, MoS magnitudes were reduced (mean across participants: approximately 20 mm) along the A/P axis, and larger MoS magnitudes (mean across participants: approximately 50 mm) along the M/L axis throughout the turn phase. Although all turns analyzed were completed successfully, the larger MoS values along the M/L axis suggest a fall potential. The variability between trials within a dancer and across participants and trials was documented and showed moderate inter-trial (16% to 51%) and across-participant CV% (range: 10% to 28%), with generally larger variations along the A/P axis. Although our results are preliminary, they suggest that the MoS may be useful for detecting faults in the control of dynamic balance in dehors pirouette performance, as a part of training and rehabilitation following injury. Full article

Understanding spatiotemporal mismatches between urban expansion and population dynamics is essential for guiding sustainable development in rapidly urbanizing regions. Using multi-source nighttime light (NTL) images and global settlement layers, this study investigates the settlement growth pattern and potential spatiotemporal mismatch with population distribution in Guangdong, China, from 1995 to 2019 at a 5-year interval. Specifically, population spatialization in urban and rural areas is separately mapped by adopting a population-based thresholding method, achieving strong agreement with the census record. Our analysis reveals distinct expansion patterns and mismatch conditions across Guangdong’s Core, Belt, and District subzones. The Core and District subzones primarily experienced infilling and edge-expansion urban growth, while the Belt subzone exhibited more dispersed spatial patterns. Notably, only 5 of 21 prefectures exhibited faster population growth than urban expansion, likely due to sustained migration driven by economic opportunities and advanced urbanization. Quantitatively, both urban expansion and population growth followed a Core, Belt, District order. Spatially, population-dominated areas were primarily clustered within 10 km of urban centers, while the District subzone extensively displayed overfilled settlements, indicating low-efficient land use. Temporally, urban growth relative to population in the Core subzone turned from slower pre-2000 to faster post-2000, followed by gradual deceleration, while the Belt subzone maintained balanced growth throughout the study period. The District subzone sustained faster urban growth from 2000 to 2019. Findings of the study provide an important reference for scientific urban planning and sustainable regional development, not only in Guangzhou but other rapidly urbanizing regions globally. Full article

Physiotherapy aims to improve postural dysfunction, often using balance exercises. The effects of rehabilitation-based balance exercises on postural control in dogs remains understudied. This study aimed to assess the impact of specific balancing exercises and blindfolding on center of pressure parameters in healthy dogs. Thirteen healthy adult dogs participated in the study. Center of pressure parameters were measured using a pressure platform during quiet standing, external perturbation, head turn, and blindfolded trials. External perturbation significantly increased the area of the elliptical sway, cranio-caudal excursion, and right–left excursion. Head turning led to large effect sizes, but no significant differences compared to quiet standing. Blindfolding led to medium to large effect sizes, though no significant differences were observed. The study confirmed that external perturbation challenges postural stability, resulting in increased sway. Head turning induces sway but may require further training or different methodologies for reliable outcomes. Blindfolding increased sway but was not statistically different. These findings underscore the potential use of perturbation-based exercises in canine rehabilitation to improve balance, while also highlighting the need for further studies to standardize balance challenges and explore the effects in dogs with orthopedic or neurological conditions. Full article

Oilfield data is characterized by complex types, large volumes, and significant noise interference, so data cleansing has become a key procedure for improving data quality. However, the traditional data cleansing process needs to deal with multiple types of problems, such as outliers, duplicate data, and missing values in turn, and the processing steps are complex and inefficient. Therefore, an integrated data cleansing and function fitting method is established. The fine-mesh data density analysis method is utilized to cleanse outliers and duplicate data, and the automated segmented fitting method is used for missing data imputation. For the real-time data generated during drilling or well logging, data cleansing is realized through grid partitioning and data density analysis, and the cleansing ratio is controlled by data density threshold and grid spacing. After data cleansing, based on similar standards, the cleansed data is segmented, and the fitting function type of each segment is determined to fill in the missing data, and data outputs with any frequency can be obtained. For the analysis of the hook load data measured by sensors at the drilling site and obtained from rig floor monitors or remote centers, the data cleansing percentage reaches 98.88% after two-stage cleansing, which still retains the original trend of the data. After data cleansing, the cleansed data are modeled through the automated segmented fitting method, with Mean Absolute Percentage Errors (MAPEs) less than 3.66% and coefficient of determination (R²) values greater than 0.94. Through the integrated data processing mechanism, the workflow can synchronously eliminate outliers and redundant data and fill in the missing values, thereby dynamically adapting to the data requirements of numerical simulation and intelligent analysis and significantly improving the efficiency of on-site data processing and decision-making reliability in the oilfield. Full article

Background and Objectives: Chronic wounds pose a significant challenge to healthcare systems, requiring long-term management and multidisciplinary approaches. The absence of a standardized national therapeutic protocol in Romania has resulted in inconsistent clinical practices, which in turn affect treatment efficacy and patient outcomes. The implementation of structured guidelines and the integration of regenerative therapies could enhance the management of chronic wounds. Materials and Methods: This study employs a cross-sectional observational design to assess the current management strategies among physicians treating chronic wounds and to identify variations in treatment approaches. A 37-question questionnaire was distributed among plastic surgeons, general surgeons, vascular surgeons, and dermatologists via Google Forms. The data collection period spanned one month, resulting in a total of 240 responses from medical centers in Bucharest, Romania. Results: The study found that most physicians treated several cases per week (40.8%) of delayed healing wounds, with the most frequent types being bedsores (57.5%) and diabetic (58.3%) or venous ulcers (55%). Challenges in wound care included patient reluctance, financial constraints, and the psychological burden on caregivers. The most relevant decision factor for surgical treatment was wound stage (86.7%). Most physicians used an initial conservative approach in wound care (52.5%) or did not have a standard approach (44.2%). Around a quarter of respondents (25.8%) used PRP as a treatment method, considering it to have moderate effectiveness (51.6%). The most important factor for encouraging PRP usage was having the necessary equipment for the procedure (72.5%). The most frequently considered benefit in the case of implementing a treatment protocol was increased treatment efficacy (62.5%). Physicians were also highly interested in the use of a standardized treatment protocol (40%). Approximately 41.7% of the physicians expressed a very high interest in having a standardized diagnostic system for chronic wounds. Conclusions: This study highlights that wound care practices remain variable and that the decision-making process is often challenging. There is a moderate belief in the effectiveness of PRP, suggesting that logistical barriers need to be addressed to facilitate access to it. Therapeutic protocols were seen as key to improving care efficacy and consistency, therefore pressing the need for national strategies that support protocol development. Full article

The residual stress induced during the processing of titanium alloy materials can significantly influence the deformation control of precision-machined workpieces, especially for workpieces characterized by low stiffness and high-precision requirements. In this study, TC18 titanium alloy forgings with a dense structure were manufactured via forging. By conducting turning and heat treatment experiments on the workpiece, the distribution and evolution of residual stress and the deformation characteristics of TC18 titanium alloy on slender shafts were systematically investigated under different turning and heat treatment conditions. Based on the experimental results, the effects of the turning parameters, including feed rate, cutting speed, cutting depth, and axial thrust force of machine tool center, on workpiece deformation were quantitatively analyzed, and an optimal heat treatment strategy was proposed. The findings indicate that between-centers turning is recommended to control workpiece deformation. Optimal turning parameters include a cutting speed of 640–800 r/min, a feed rate of 0.05–0.1 mm/r, a cutting depth of 0.1 mm, and a thrust force of the center set to 10% of the rated value, resulting in minimal deformation and superior surface quality. In addition, during the heat treatment annealing of slender shaft titanium alloys, residual stress is effectively eliminated at temperatures ranging from 640 to 680 °C with a holding time of 1–3 h. Furthermore, the vertically fixed placement method during heat treatment reduced deformation by approximately 50% compared to free placement. These results provide valuable insights for optimizing machining and heat treatment processes to enhance the dimensional stability of titanium alloy components. Full article

Background: The COVID-19 pandemic necessitated immediate regulatory vaccine approvals to facilitate timely global access. The prevailing differences in economies and resources and the varying maturity of the regulatory systems worldwide resulted in different levels of capacity to ensure vaccine quality, safety, and efficacy. In addition to the Emergency Use Authorization or equivalent by some advanced regulatory agencies, the WHO issued Emergency Use Listings (EULs), among other tools, to streamline and expedite regulatory approvals globally. This study aimed to assess the regulatory strategies and best practices adopted during the COVID-19 vaccine approvals and gather lessons for future emergency preparedness. Methods: A mixed-method approach employing qualitative desk reviews and a cross-sectional study collected data from 194 national regulatory authorities (NRAs) across all WHO regions. Results: Three main approval processes were identified: procurement-driven, reliance-based, and independent evaluations. Wealthier countries with more mature regulatory systems were found to spend a longer time issuing approvals, primarily due to being the initial assessors of the vaccines’ quality, safety, and efficacy. Furthermore, various regulatory flexibilities and best practices centered around regulatory reliance, rolling reviews, fast-tracking reviews, and employing digital tools were identified. Notably, the WHO’s EULs were essential in facilitating the timely approval of vaccines globally, including in low- and middle-income countries. Conclusions: The findings suggest a significant turn in vaccine regulation theories and practice, emphasizing balancing speed with scientific validity. This necessitates the creation of thorough provisions for emergency preparedness, regulatory reliance, and administrative flexibility in regulatory practices worldwide. Full article