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Search Results (175)

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9 pages, 915 KiB  
Article
Synopsis of the Genus Trichorondonia Breuning, 1965 with Description of a New Species from China (Coleoptera: Cerambycidae)
by Ruigang Yang, Jianhua Huang and Guanglin Xie
Insects 2025, 16(7), 743; https://doi.org/10.3390/insects16070743 - 21 Jul 2025
Viewed by 293
Abstract
This paper provides a brief review of the genus Trichorondonia Breuning, 1965. A new species, Trichorondonia wenkaii sp. nov. (文凯毛郎氏天牛), is described and illustrated. Trichorondonia kabateki Viktora, 2024 is newly recorded in Hubei province, with the first description of the male. Additionally, photographs [...] Read more.
This paper provides a brief review of the genus Trichorondonia Breuning, 1965. A new species, Trichorondonia wenkaii sp. nov. (文凯毛郎氏天牛), is described and illustrated. Trichorondonia kabateki Viktora, 2024 is newly recorded in Hubei province, with the first description of the male. Additionally, photographs of the holotypes of three previously described species are presented. A key to the four species is given. The new species differs from T. pilosipes and T. hybolasioides in having elytra with rounded lateral apical angles and a vertex with blackish-brown pubescence medially behind the eyes. The new species can also be easily distinguished from T. kabateki by the antennae being ventrally fringed with sparse hairs only on segments 1–8, the greyish-yellow pubescence on the pronotum being unevenly distributed and particularly sparse in the posterior half, the elytra having rather thin greyish-yellow pubescence and hardly visible greyish-white pubescence, elongated blackish-brown spots on the elytral longitudinal carinae, and a small tuft of black setae at the centre of the elytral base where there is no obvious tubercle. The type specimen of the new species was collected in Dianping village, Xinhua town, Leye county, Guangxi Zhuang Autonomous Region of China, and deposited at Insect Collection, College of Agriculture, Yangtze University, Jingzhou, Hubei, China (ICYZU). Full article
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13 pages, 3483 KiB  
Article
The “Double-Row Shoelace” Capsulodesis: A Novel Technique for the Repair and Reconstruction of the Scapholunate Ligament of the Wrist
by Adriano Cannella, Rocco De Vitis, Arturo Militerno, Giuseppe Taccardo, Vitale Cilli, Lorenzo Rocchi, Giulia Maria Sassara and Marco Passiatore
Surgeries 2025, 6(3), 57; https://doi.org/10.3390/surgeries6030057 - 16 Jul 2025
Viewed by 174
Abstract
Introduction: The scapholunate interosseus ligament (SLIL) is critical for wrist stability, with injuries causing carpal instability and potential scapholunate advanced collapse (SLAC). This technical note presents a novel ligament-sparing surgical technique for treating SLIL tears ranging from grade 2 to 4 of the [...] Read more.
Introduction: The scapholunate interosseus ligament (SLIL) is critical for wrist stability, with injuries causing carpal instability and potential scapholunate advanced collapse (SLAC). This technical note presents a novel ligament-sparing surgical technique for treating SLIL tears ranging from grade 2 to 4 of the Garcia-Elias classification. Materials and Methods: A retrospective study was performed on ten patients treated with this novel technique. The technique involves a dorsal approach to the wrist through a 5–7 cm incision ulnar to Lister’s tubercle. After exposing the scapholunate joint, reduction is performed using Kirschner wires (K-wires) as joysticks, followed by stabilisation with three K-wires through the scapholunate, scapho-capitate, and radio-lunate joints. Two 2.3 mm suture anchors with double sutures are placed where the reduction K-wires were removed. One pair of sutures connects the anchors and any remaining SLIL tissue, while the second pair create a shoelace-like capsulodesis. Post-operative care includes staged K-wire removal at one and two months, with progressive rehabilitation before returning to weight-bearing activities at six months. Results: All patients improved in pain and function. The technique addresses SLIL injuries by restoring both coronal alignment through ligament repair and sagittal alignment via dorsal capsulodesis. The use of suture anchors and direct repair preserves the native tissue while reinforcing the dorsal capsule–scapholunate septum complex, avoiding the need for tendon grafts or extensive bone tunnelling. Conclusions: This ligament-sparing technique offers several advantages, including absence of donor site morbidity, minimal damage to carpal cartilage and vascularity, and preservation of surgical options should revision be necessary. The procedure effectively addresses both components of scapholunate instability while maintaining a relatively straightforward surgical approach. Full article
(This article belongs to the Section Hand Surgery and Research)
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13 pages, 3735 KiB  
Article
The Genus Tegonotus Nalepa (Acariformes: Eriophyidae: Phyllocoptinae): Description of a New Species and Key to Valid Species
by Eid Muhammad Khan, Jawwad Hassan Mirza, Muhammad Kamran and Fahad Jaber Alatawi
Diversity 2025, 17(7), 465; https://doi.org/10.3390/d17070465 - 2 Jul 2025
Viewed by 261
Abstract
The genus Tegonotus Nalepa (Acariformes: Eriophyidae: Phyllocoptinae) is recorded for the first time from Saudi Arabia with the description of a new species, T. saudiensis sp. nov., collected from the inner fronds of Phoenix dactylifera L. (Arecaceae), described and illustrated based on females. [...] Read more.
The genus Tegonotus Nalepa (Acariformes: Eriophyidae: Phyllocoptinae) is recorded for the first time from Saudi Arabia with the description of a new species, T. saudiensis sp. nov., collected from the inner fronds of Phoenix dactylifera L. (Arecaceae), described and illustrated based on females. The individuals of the new species were vagrant on the abaxial leaf surface, causing no apparent damage to the host plant. The taxonomic status of the genus and its species was thoroughly assessed through the literature-based analysis of morphological characters. Consequently, the diagnosis of the genus Tegonotus is updated, and a key to 47 valid species is provided. Eight Tegonotus species are suggested to be transferred to three different genera within the tribe. A brief discussion on the taxonomic status of these species is provided. The position of scapular tubercles and setae (sc), and shape of the dorsal pedipalp genu seta (d), were found to be significant for the generic designation. Full article
(This article belongs to the Special Issue Diversity, Ecology, and Conservation of Mites)
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68 pages, 10407 KiB  
Review
Bioinspired Morphing in Aerodynamics and Hydrodynamics: Engineering Innovations for Aerospace and Renewable Energy
by Farzeen Shahid, Maqusud Alam, Jin-Young Park, Young Choi, Chan-Jeong Park, Hyung-Keun Park and Chang-Yong Yi
Biomimetics 2025, 10(7), 427; https://doi.org/10.3390/biomimetics10070427 - 1 Jul 2025
Viewed by 1272
Abstract
Bioinspired morphing offers a powerful route to higher aerodynamic and hydrodynamic efficiency. Birds reposition feathers, bats extend compliant membrane wings, and fish modulate fin stiffness, tailoring lift, drag, and thrust in real time. To capture these advantages, engineers are developing airfoils, rotor blades, [...] Read more.
Bioinspired morphing offers a powerful route to higher aerodynamic and hydrodynamic efficiency. Birds reposition feathers, bats extend compliant membrane wings, and fish modulate fin stiffness, tailoring lift, drag, and thrust in real time. To capture these advantages, engineers are developing airfoils, rotor blades, and hydrofoils that actively change shape, reducing drag, improving maneuverability, and harvesting energy from unsteady flows. This review surveys over 296 studies, with primary emphasis on literature published between 2015 and 2025, distilling four biological archetypes—avian wing morphing, bat-wing elasticity, fish-fin compliance, and tubercled marine flippers—and tracing their translation into morphing aircraft, ornithopters, rotorcraft, unmanned aerial vehicles, and tidal or wave-energy converters. We compare experimental demonstrations and numerical simulations, identify consensus performance gains (up to 30% increase in lift-to-drag ratio, 4 dB noise reduction, and 15% boost in propulsive or power-capture efficiency), and analyze materials, actuation, control strategies, certification, and durability as the main barriers to deployment. Advances in multifunctional composites, electroactive polymers, and model-based adaptive control have moved prototypes from laboratory proof-of-concept toward field testing. Continued collaboration among biology, materials science, control engineering, and fluid dynamics is essential to unlock robust, scalable morphing technologies that meet future efficiency and sustainability targets. Full article
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24 pages, 4371 KiB  
Article
Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression
by G. Lorenzo Odierna, Christopher F. Sharpley, Vicki Bitsika, Ian D. Evans and Kirstan A. Vessey
Neurol. Int. 2025, 17(6), 96; https://doi.org/10.3390/neurolint17060096 - 19 Jun 2025
Viewed by 618
Abstract
Background/Objectives: Major Depression (MD) is a common disorder that has significant social and economic impacts. Approximately 30% of all MD patients are refractory to common treatments, representing a major obstacle to managing the impacts of depression. One potential explanation for the incomplete treatment [...] Read more.
Background/Objectives: Major Depression (MD) is a common disorder that has significant social and economic impacts. Approximately 30% of all MD patients are refractory to common treatments, representing a major obstacle to managing the impacts of depression. One potential explanation for the incomplete treatment efficacy in MD is a substantial divergence in the mechanisms and brain networks involved in different subtypes of the disorder. The aim of this study was to identify novel brain regional targets for MD clinical screening using a gene-informed approach. Methods: A new analysis pipeline, called “Analysis Tool for Local Association of Neuronal Transcript Expression” (ATLANTE), was generated and validated. The pipeline identifies brain regions based on the shared high expression of user-generated gene lists; in this study, the pipeline was applied to discover brain regions that may be significant to MD. Results: Nine discrete brain regions of interest to MD were identified, including the temporal pole, anterior transverse temporal gyrus (Heschl’s gyrus), olfactory tubercle, ventral tegmental area, postcentral gyrus, CA1 of the hippocampus, olfactory area, perirhinal gyrus, and posterior insular cortex. The application of network and clustering analyses identified genes of special importance, including, most notably, PRKN. Conclusions: This study provides two major insights. The first is that several brain regions have unique MD-associated genetic architectures, indicating a potential explanation for subtype-specific dysfunction. The second insight is that the PRKN gene, which is strongly associated with Parkinson’s disease, is a key player amongst the MD-associated genes. These findings reveal novel targets for the clinical screening of depression and reinforce a mechanistic connection between MD and Parkinson’s disease. Full article
(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
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12 pages, 1225 KiB  
Article
Sonographic Evaluations of the Pubic Symphysis at Different Stages of Pregnancy
by Slawomir Wozniak, Aleksandra Piatek, Bozena Kurc-Darak, Zygmunt Domagala, Friedrich Paulsen and Jerzy Florjanski
J. Clin. Med. 2025, 14(11), 3898; https://doi.org/10.3390/jcm14113898 - 1 Jun 2025
Viewed by 1270
Abstract
Background/Objectives: The pubic symphysis is formed by the fusion of the right and left pubic bones. The metrics, such as breadth, length, and depth, increase during pregnancy and can be measured and analyzed using standard sonography. Obstetricians require clear and consistent criteria [...] Read more.
Background/Objectives: The pubic symphysis is formed by the fusion of the right and left pubic bones. The metrics, such as breadth, length, and depth, increase during pregnancy and can be measured and analyzed using standard sonography. Obstetricians require clear and consistent criteria for standard sonography evaluation. Methods: Sonographic examinations were performed on a cohort of 225 pregnant women, aged between 23 and 41 years, as part of a prospective observational study. The parameters measured included pubic symphysis entry middle width, intertubercular distance, pubic symphysis width, and pubic symphysis depth. Results: The width of the pubic symphysis exhibited the greatest consistency, measuring between 2.2 and 11.3 mm, whereas the depth displayed the highest variability, ranging from 5.4 to 22.6 mm. The measurements most correlated with fetal weight included pubic symphysis entry width (6.5 ± 3.4 mm; p ˂ 0.001), pubic symphysis width (6.4 ± 2.9 mm; p ˂ 0.001), and depth (14.8 ± 4.8 mm; p = 0.03). The intertubercular distance exhibited the strongest correlation with maternal age (15.1 ± 5.4 mm; p = 0.03). In contrast, pubic symphysis entry width (6.4 ± 3.3 mm; p = 0.02; 6.4 ± 3.4 mm; p ˂ 0.001) and pubic symphysis width (6.3 ± 2.6 mm; p = 0.01; 6.3 ± 2.6; p ˂ 0.001) demonstrated stronger associations with maternal weight and weight gained during pregnancy, respectively. In the singular pregnancy group, the width of the pubic symphysis exhibited significant correlations with fetal weight categories: under or equal to 1000 g (4.56 ± 1.5 mm; p = 0.02), 1001–2000 g (5.51 ± 2.6 mm; p = 0.02), and more than 3000 g (7.3 ± 3.9 mm; p = 0.02). Pubic symphysis entry width is significantly correlated with fetal weight in the range of 1001–2000 g (5.5 ± 3 mm; p = 0.02) and fetal weight exceeding 3000 g (7.4 ± 3.9 mm; p = 0.02). In singular pregnancies, statistically significant differences were noted in intertubercular distance (15.9 ± 7.2 mm vs. 13.4 ± 6.2 mm; p = 0.03) when comparing fetuses weighing 2000 g or less between nulliparous and multiparous women. Conclusions: Fetal and maternal weight were the primary parameters that were positively correlated with these measurements. The term ‘pubic symphysis entry’ is proposed to describe a trapezoidal space situated superior to the pubic symphysis disc, delineated by an imaginary line connecting the bilateral pubic tubercles. Full article
(This article belongs to the Section Obstetrics & Gynecology)
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19 pages, 7427 KiB  
Article
Analysis of Meiotic Behavior and 2n Pollen Formation Frequency in Triploid Hybrids of Chinese Jujube
by Yunxi Zhong, Lixin Ge, Yinfang Song, Zhi Luo, Jiurui Wang, Mengjun Liu and Fenfen Yan
Plants 2025, 14(11), 1643; https://doi.org/10.3390/plants14111643 - 28 May 2025
Viewed by 437
Abstract
The Chinese jujube (Ziziphus jujuba Mill.), an economically significant fruit tree native to China, is valued for both fresh and dried uses. In plants, 2n gametes serve as the fundamental basis for creating a sexual polyploid germplasm. This study investigated the 2n [...] Read more.
The Chinese jujube (Ziziphus jujuba Mill.), an economically significant fruit tree native to China, is valued for both fresh and dried uses. In plants, 2n gametes serve as the fundamental basis for creating a sexual polyploid germplasm. This study investigated the 2n gametogenesis frequency in triploid hybrid jujubes through meiotic analysis of the hybrid strain Q161 and a two-year pollen analysis on hybrid progeny, assessing the natural 2n pollen frequencies to identify a high-2n-pollen germplasm and revealing the occurrence of 2n pollen. Meiotic analysis of the triploid hybrid Q161 (2n = 36) revealed cytological anomalies, including binucleate cells (22.80% abnormal tetrads), with natural 2n pollen production rates reaching 4.00% and 4.67% over two consecutive years. Scanning electron microscopy (SEM) revealed that the 2n pollen exhibited pronounced exine ornamentation with cerebroid sculpturing and tubercle-like structures at the apertures. Analysis of the triploid progeny for two consecutive years demonstrated a pollen viability of 30.45% and 23.83% (CV: 19. 39–29.69%), with the mean 2n pollen frequencies of 22.52% and 7.64%, peaking at 52.16% and 28.95% in elite individuals. Six triploid germplasm accessions with naturally elevated 2n pollen frequencies were identified. Under natural conditions, a triploid hybrid germplasm in Chinese jujube produces 2n pollen grains due to abnormal meiotic behavior, and a natural triploid germplasm with high pollen productivity was identified. This research provides a critical theoretical foundation for sexual polyploid breeding strategies. Full article
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20 pages, 8549 KiB  
Article
Ultrastructural Characterization of Developmental Stages and Head Sensilla in Portici okadai, Vector of Thelazia callipaeda
by Da Sun, Yang Luo, Yikang Wang, Hongle Cui, Yanting Gou, Juan Zhou, Bo Luo, Hui Liu, Rong Yan and Lingjun Wang
Insects 2025, 16(5), 539; https://doi.org/10.3390/insects16050539 - 20 May 2025
Viewed by 550
Abstract
Phortica okadai, a vector of Thelazia callipaeda, is associated with an increasing incidence of thelaziasis. The complex habitat and chemosensory system of P. okadai are critical for its proliferation and expansion. However, ultrastructural data across developmental stages remain limited. This study [...] Read more.
Phortica okadai, a vector of Thelazia callipaeda, is associated with an increasing incidence of thelaziasis. The complex habitat and chemosensory system of P. okadai are critical for its proliferation and expansion. However, ultrastructural data across developmental stages remain limited. This study used scanning electron microscopy to examine the ultrastructure of P. okadai developmental stages, with a focus on head sensilla. The results showed that the eggs of P. okadai are dark brown and cylindro-oval. The larvae are vermiform, divided into 11 segments. The pupae are marked by a conspicuous respiratory tubercle, and the posterior spiracle contains three distinct spiracular slits. Among five types of sensilla (trichoid, intermediate, chaetica, coeloconic, and basiconic), coeloconic, intermediate, and trichoid sensilla were predominantly found on the antennae, while basiconic and chaetica sensilla were distributed on both the antennae and the maxillary palps of P. okadai. The analysis revealed that the absence of dorsal appendages on the eggs distinguishes P. okadai from D. melanogaster. Males have longer antennae and exhibit sexual dimorphism in the length of sensilla (ChII, TB, and LB). This study provides the first comprehensive ultrastructural characterization of P. okadai developmental stages and head sensilla, laying a foundation for species identification and olfactory system research. Full article
(This article belongs to the Section Insect Physiology, Reproduction and Development)
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14 pages, 3046 KiB  
Article
Lingual Foramina Anatomy: An Observational Study in Dry Mandibles
by Charalambos Tsatsarelis, Zoi Maria Thomaidi and Vasileios Papadopoulos
Dent. J. 2025, 13(5), 218; https://doi.org/10.3390/dj13050218 - 19 May 2025
Viewed by 352
Abstract
Background/Objectives: The lingual foramina of the mandible serve as passageways for arterial branches that are susceptible to injury during surgical procedures, potentially leading to varying degrees of hemorrhage. The objective of the present study was to contribute to the quantification and classification [...] Read more.
Background/Objectives: The lingual foramina of the mandible serve as passageways for arterial branches that are susceptible to injury during surgical procedures, potentially leading to varying degrees of hemorrhage. The objective of the present study was to contribute to the quantification and classification of lingual foramina using cadaveric dry mandibles in relation to surgical safety and, especially, to the risk of perioperative bleeding. Methods: This study examined the number, diameter, and spatial relationship of lingual foramina to the genial tubercle, alveolar process, and alveolar crest in dry mandibles. Stainless steel wire threads and Digimatic caliper measurements were utilized. Cluster analysis was employed for the classification of foramina into distinct spatial groups. One-way analysis of variance (ANOVA) was used to compare mean values among ≥3 groups. Results: A total of 100 dry mandibles were initially analyzed for the presence of lingual foramina with a diameter of ≥2 mm. In 96 of them (50 dentate and 46 edentulous), 387 lingual foramina (mean: 4.03 per mandible) were recognized; the remaining 4 had smaller lingual foramina (diameter <2 mm). Only 4 mandibles (4.2%) exhibited a single lingual foramen, whereas the remaining 92 (95.8%) displayed multiple foramina (up to nine). The observed lingual foramina had a diameter of 0.44 ± 0.02 mm and were located at distances of 8.74 ± 0.54 mm from the genial tubercle, 14.19 ± 0.87 mm from the alveolar crest, and 14.53 ± 0.84 mm from the inferior border of the mandible. Based on their relationship to the genial tubercle, the foramina were classified into four distinct groups: (i) right (27/387—7%), (ii) proximal (254/387—66%), (iii) superior (81/387—21%), and (iv) left (25/387—6%). The superior group exhibited the largest mean diameter (0.52 ± 0.22 mm, ANOVA p < 0.001). The probability of detecting a lingual foramen was minimized at a distance of 13.00 ± 0.50 mm from the genial tubercle, delineating a relatively safe zone with a lower risk of hemorrhage. Conclusions: This study provides anatomical insights that contribute to appropriate preoperative planning and the minimization of complications during surgical interventions on the mandible. Full article
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20 pages, 7480 KiB  
Article
The Coracohumeral Ligament and Its Fascicles: An Anatomic Study
by Emilio González-Arnay, Isabel Pérez-Santos, Camino Braojos-Rodríguez, Artimes García-Parra, Elena Bañón-Boulet, Noé Liria-Martín, Lidia Real-Yanes and Mario Fajardo-Pérez
J. Funct. Morphol. Kinesiol. 2025, 10(2), 149; https://doi.org/10.3390/jfmk10020149 - 27 Apr 2025
Viewed by 893
Abstract
Background: The coracohumeral ligament (CHL) is inserted in the coracoid process, from which it extends laterally and caudally, blending with the tendinous insertions of the subscapularis muscle and the supraspinatus muscle, with a third intermediate area between the muscles inserted between the humeral [...] Read more.
Background: The coracohumeral ligament (CHL) is inserted in the coracoid process, from which it extends laterally and caudally, blending with the tendinous insertions of the subscapularis muscle and the supraspinatus muscle, with a third intermediate area between the muscles inserted between the humeral tubercles, and it contributes to the fibrous tunnel that engulfs the long head of the biceps tendon. Most previous studies mention insertions from the base of the coracoid process, but not from the tip, and some authors describe anterior and posterior columns. In contrast, others stress the existence of superficial and deep fascicles. Also, the relationship between the coracohumeral and the glenohumeral ligaments is unclear. Given the position of the CHL covering most of the rotator interval, and its role in the stability of the shoulder capsule and pathologies like frozen shoulder, a clear description of its fascicles in a plane-wise manner might be helpful for a selective surgical approach. Methods: We studied sixteen soft-embalmed shoulders to avoid misclassifying fascicles due to formalin-linked tissue amalgamation. Further histological assessment was performed on the two remaining non-embalmed shoulders. Results: In our sample, the coracohumeral ligament hung from the anterior and posterior edges of the coracoid process’ inferior surface, defining two columns that converged near the tip of the coracoid process. Both columns were formed by superficial and deep fascicles directed to different depths of the rotator cuff, usually via the rotator interval, fusing with the connective tissue around the muscles without direct distal attachments. We performed histological and morphometrical assessments, and we discuss clinical and biomechanical implications. Conclusions: The coracohumeral ligament contains four fascicles that fuse with the connective tissue of the shoulder joint, forming a double necklace around the subscapularis and supraspinatus. Therefore, its functions probably extend beyond simple vertical stabilization. Full article
(This article belongs to the Section Functional Anatomy and Musculoskeletal System)
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11 pages, 4471 KiB  
Article
Tibial Tubercle Avulsion Fracture in Young Athletes Surgically Treated: Mid-Long Term Result and Comparison
by Lorenzo Moretti, Carlo Amati, Alessandro Geronimo, Andrea Michele Abbaticchio, Maria Paola Miolla, Daniela Dibello and Giuseppe Solarino
Children 2025, 12(5), 533; https://doi.org/10.3390/children12050533 - 22 Apr 2025
Viewed by 467
Abstract
Objectives: Tibial apophysis avulsion fracture is an unusual injury in young pediatric athletes. The mechanism of injury is often related to sports (i.e football and basketball). Fifteen patients who had this kind of fracture underwent surgical Open Reduction and Internal Fixation (ORIF) [...] Read more.
Objectives: Tibial apophysis avulsion fracture is an unusual injury in young pediatric athletes. The mechanism of injury is often related to sports (i.e football and basketball). Fifteen patients who had this kind of fracture underwent surgical Open Reduction and Internal Fixation (ORIF) with two or three cannulated screws and tendon stripping. In this kind of injury and treatment, one of the most important concerns is the recovery of the extensor apparatus strength of the lower limb. Materials and Methods: We followed up the patients for 12 months, performing biomechanical tests and a kinetic analysis to evaluate the activation of the leg muscles such as rectus femoris, vastus medialis, vastus lateralis, and semitendinosus muscle fibers and compared them with the contralateral healthy limb. Results: The results showed that there was an almost complete recovery of muscle strength activation without any statistically significant differences compared to the healthy limb. Conclusions: This surgical treatment appears to be safe and effective in the treatment of tibial apophysis fractures in young athletes, since this type of surgical treatment does not compromise the recovery of the extensor apparatus strength and/or return to sport of the lower limb in case of tibial apophysis fractures in young athletes. Full article
(This article belongs to the Section Pediatric Orthopedics & Sports Medicine)
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12 pages, 2953 KiB  
Article
Chronic Cavitary Pulmonary Histoplasmosis–Novel Concepts Regarding Pathogenesis
by John F. Fisher, Michael Saccente, George S. Deepe, Natasha M. Savage, Wajih Askar and Jose A. Vazquez
J. Fungi 2025, 11(3), 201; https://doi.org/10.3390/jof11030201 - 5 Mar 2025
Viewed by 1076
Abstract
Because the apices of the lungs are most commonly involved in chronic cavitary histoplasmosis (CCPH), it has been assumed by many to have a pathogenesis which is similar to post-primary tuberculosis. Fungi such as Aspergillus may colonize pulmonary bullae. Although less common, colonization [...] Read more.
Because the apices of the lungs are most commonly involved in chronic cavitary histoplasmosis (CCPH), it has been assumed by many to have a pathogenesis which is similar to post-primary tuberculosis. Fungi such as Aspergillus may colonize pulmonary bullae. Although less common, colonization by Histoplasma capsulatum in a heavily endemic area is possible or even probable. In chronic obstructive pulmonary disease (COPD), apical bullae are characteristic. Since COPD is common and CCPH is rare, the pathogenesis of CCPH remains incompletely understood. What is presently known about the pathogenesis of CCPH has not changed appreciably since 1976. A cellblock from a patient with CCPH was analyzed with histochemical stains for T cells, B cells, plasma cells, and macrophages to better understand the pathogenesis of CCPH. The pathogenesis of cavitary disease in histoplasmosis has been assumed to resemble that of tuberculosis. However, liquefaction of a caseous focus in lung apices which resulted from blood-borne tubercle bacilli is distinctly unlike CCPH, as caseation is unusual. Rather, repeated colonization of the apical and other bullae by propagules (microconidium, macroconidium, hyphal fragment) of H. capsulatum in patients with COPD who have resided in heavily endemic areas appears to be the primary event in CCPH. Immunohistochemical enumeration of specific cell types in a patient with CCPH has not been previously carried out to our knowledge, but is only a first step in understanding the disease. In future studies, identification of the varieties of macrophages and cytokines in CCPH may reveal whether the process is pro-inflammatory, anti-inflammatory, or both. Full article
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15 pages, 5365 KiB  
Article
Computed Tomography Angiography-Guided Study of the Superficial Femoral Artery Course in the Thigh and the Identification of Dangerous Zones for Lateral Femoral Surgical Approaches
by Yılmaz Mertsoy, Şeyhmus Kavak and Ayhan Şenol
Medicina 2025, 61(3), 441; https://doi.org/10.3390/medicina61030441 - 28 Feb 2025
Viewed by 688
Abstract
Background and Objectives: The superficial femoral artery (SFA) can be injured during an intramedullary femoral nailing procedure with proximal and distal cross fixation, performed for proximal femoral fractures and intertrochanteric fractures. The aim of this study was to determine the safe and [...] Read more.
Background and Objectives: The superficial femoral artery (SFA) can be injured during an intramedullary femoral nailing procedure with proximal and distal cross fixation, performed for proximal femoral fractures and intertrochanteric fractures. The aim of this study was to determine the safe and dangerous zones for the SFA during operative interventions on the femoral body in Turkish society and to define the relationship of these zones with femur length and sex. Materials and Methods: Using a computed tomography angiography, the relationship between the SFA and the medial shaft of the femur was examined in 160 limbs of 80 patients. The upper and lower cut points of the medial part of the SFA in the sagittal plane were defined. The distance of these points to the adductor tubercle was measured and the ratio of this value to the femur length was calculated. Results: The average distance of the SFA to the adductor tubercle in women was 214.2 ± 25.9 mm at the anterior border of the femur, while in men it was 229.8 ± 26.2 mm (p = 0.000). The danger zone length was 85 mm in women and 102 mm in men, and the difference was statistically significant (p = 0.000). The average distance of the SFA to the adductor tubercle at the anterior border of the femur was 223.1 ± 27.3 mm, the average femur length was 374.9 ± 30.2 mm, and a moderate correlation was found between them (r = 0.568). Conclusions: When determining the intraoperative danger zone using anatomical reference points in surgical approaches to the femur, variables such as sex and femur length should not be ignored. Full article
(This article belongs to the Special Issue Clinical Research in Orthopaedics and Trauma Surgery)
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20 pages, 6161 KiB  
Article
Differences in Formation of Prepuce and Urethral Groove During Penile Development Between Guinea Pigs and Mice Are Controlled by Differential Expression of Shh, Fgf10 and Fgfr2
by Shanshan Wang and Zhengui Zheng
Cells 2025, 14(5), 348; https://doi.org/10.3390/cells14050348 - 27 Feb 2025
Viewed by 814
Abstract
The penile tubular urethra forms by canalization of the urethral plate without forming an obvious urethral groove in mice, while the urethral epithelium forms a fully open urethral groove before urethra closure through the distal-opening-proximal-closing process in humans and guinea pigs. Our knowledge [...] Read more.
The penile tubular urethra forms by canalization of the urethral plate without forming an obvious urethral groove in mice, while the urethral epithelium forms a fully open urethral groove before urethra closure through the distal-opening-proximal-closing process in humans and guinea pigs. Our knowledge of the mechanism of penile development is mainly based on studies in mice. To reveal how the fully opened urethral groove forms in humans and guinea pigs, we compared the expression patterns and levels of key developmental genes using in situ hybridization and quantitative PCR during glans and preputial development between guinea pigs and mice. Our results revealed that, compared with mouse preputial development, which started before sexual differentiation, preputial development in guinea pigs was delayed and initiated at the same time that sexual differentiation began. Fgf10 was mainly expressed in the urethral epithelium in developing genital tubercle (GT) of guinea pigs. The relative expression of Shh, Fgf8, Fgf10, Fgfr2, and Hoxd13 was reduced more than 4-fold in the GT of guinea pigs compared to that of mice. Hedgehog and Fgf inhibitors induced urethral groove formation and restrained preputial development in cultured mouse GT, while Shh and Fgf10 proteins induced preputial development in cultured guinea pig GT. Our discovery suggests that the differential expression of Shh and Fgf10/Fgfr2 may be the main reason a fully opened urethral groove forms in guinea pigs, and it may be similar in humans as well. Full article
(This article belongs to the Section Reproductive Cells and Development)
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19 pages, 1122 KiB  
Review
Unlocking the Mystery of Patella Dislocation—Diagnostic Methods in Pediatric Populations: A Comprehensive Narrative Review
by Ewa Tramś, Ignacy Tołwiński, Marcin Tyrakowski, Dariusz Grzelecki, Jacek Kowalczewski and Rafał Kamiński
J. Clin. Med. 2025, 14(4), 1376; https://doi.org/10.3390/jcm14041376 - 19 Feb 2025
Cited by 1 | Viewed by 1097
Abstract
Background/Objectives: The diagnostic guidelines for pediatric patellofemoral instability (PFI) remain incomplete. PFI remains a challenging issue as it affects the biomechanics of the knee joint, triggers anterior knee pain, and is linked to the development of early-onset osteoarthritis. The diagnostic process is complicated [...] Read more.
Background/Objectives: The diagnostic guidelines for pediatric patellofemoral instability (PFI) remain incomplete. PFI remains a challenging issue as it affects the biomechanics of the knee joint, triggers anterior knee pain, and is linked to the development of early-onset osteoarthritis. The diagnostic process is complicated by numerous anatomical factors that must be considered. This review aims to consolidate current knowledge presented in the literature on radiological diagnostics for PFI in pediatric populations, with the application of all imaging techniques—including ultrasonography (US), magnetic resonance imaging (MRI), computed tomography (CT), and radiography (RTG)—which enable the evaluation of anatomical risk factors critical for the diagnosis, prevention, and treatment of PFI. Methods: A search of the PubMed/MEDLINE database was conducted to identify relevant studies from 1975 to 2024. The search terms were as follows: (patellar or patella) and (instability or displacement or dislocation) and (diagnostic or diagnosis or imaging or radiographic). A total of 2743 articles were retrieved, which were screened to yield 29 studies for further review. These studies were then divided into seven categories regarding the diagnostic methods: risk factors, tibial tubercle trochlear groove (TT-TG)/tibial tubercle posterior cruciate ligament (TT-PCL), MPFL injury and cartilage damage, patella and trochlear dysplasia, torsional abnormalities, coronal plane alignment, and genetics. Results: The methods presented statistically significant differences, with those most commonly used for the diagnosis of patella dislocation being TT-TG index, MPFL rapture, and trochlear dysplasia. Conclusions: In summary, multiple diagnostic tools, including MRI, CT, X-ray, and physical examination, are available for the assessment of PFI, each contributing to treatment decisions. Although MRI remains the primary diagnostic tool, further research is needed to establish more precise diagnostic criteria. Full article
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