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25 pages, 6900 KiB  
Article
Detection of Trends and Anomalies with MACD and RSI Market Indicators for Temperature and Precipitation
by Yunus Ziya Kaya
Symmetry 2025, 17(8), 1268; https://doi.org/10.3390/sym17081268 (registering DOI) - 8 Aug 2025
Abstract
The changes in climatological variables are a critical concern for climatologists, hydrologists, and water resources managers. In the face of global climate change, a more profound understanding of the recent changes in climatological conditions of a specific region is becoming increasingly urgent. To [...] Read more.
The changes in climatological variables are a critical concern for climatologists, hydrologists, and water resources managers. In the face of global climate change, a more profound understanding of the recent changes in climatological conditions of a specific region is becoming increasingly urgent. To this end, hydro-climatological time series are being investigated in various ways, from traditional approaches to state-of-the-art techniques. This manuscript investigates the trend changes of surface temperature and total precipitation hydro-climatological parameters over a long period, using two of the most popular market price trend detection indicators, MACD and RSI. The RSI indicator evaluation methodology has been modified for the hydro-climatological time series. Minimum, maximum, mean surface temperatures, and precipitation parameters were analyzed. The length of the data sets is 122 years, starting in 1901 and ending in 2022. The application of these indicators to the mentioned parameters underscores their potential as powerful tools in the detection of climatological trends and trend variability over time, highlighting the need for proactive climate management strategies. The results revealed that the MACD and RSI indicators are effective tools not only for trend detection but also for determining climatological anomalies. These tools can be used to complement traditional statistical trend analysis. Moreover, their visual capabilities allow the methods to offer a more comprehensive understanding of climate management strategies. Full article
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111 pages, 6426 KiB  
Article
Economocracy: Global Economic Governance
by Constantinos Challoumis
Economies 2025, 13(8), 230; https://doi.org/10.3390/economies13080230 (registering DOI) - 7 Aug 2025
Abstract
Economic systems face critical challenges, including widening income inequality, unemployment driven by automation, mounting public debt, and environmental degradation. This study introduces Economocracy as a transformative framework aimed at addressing these systemic issues by integrating democratic principles into economic decision-making to achieve social [...] Read more.
Economic systems face critical challenges, including widening income inequality, unemployment driven by automation, mounting public debt, and environmental degradation. This study introduces Economocracy as a transformative framework aimed at addressing these systemic issues by integrating democratic principles into economic decision-making to achieve social equity, economic efficiency, and environmental sustainability. The research focuses on two core mechanisms: Economic Productive Resets (EPRs) and Economic Periodic Injections (EPIs). EPRs facilitate proportional redistribution of resources to reduce income disparities, while EPIs target investments to stimulate job creation, mitigate automion-related job displacement, and support sustainable development. The study employs a theoretical and analytical methodology, developing mathematical models to quantify the impact of EPRs and EPIs on key economic indicators, including the Gini coefficient for inequality, unemployment rates, average wages, and job displacement due to automation. Hypothetical scenarios simulate baseline conditions, EPR implementation, and the combined application of EPRs and EPIs. The methodology is threefold: (1) a mathematical–theoretical validation of the Cycle of Money framework, establishing internal consistency; (2) an econometric analysis using global historical data (2000–2023) to evaluate the correlation between GNI per capita, Gini coefficient, and average wages; and (3) scenario simulations and Difference-in-Differences (DiD) estimates to test the systemic impact of implementing EPR/EPI policies on inequality and labor outcomes. The models are further strengthened through tools such as OLS regression, and Impulse results to assess causality and dynamic interactions. Empirical results confirm that EPR/EPI can substantially reduce income inequality and unemployment, while increasing wage levels, findings supported by both the theoretical architecture and data-driven outcomes. Results demonstrate that Economocracy can significantly lower income inequality, reduce unemployment, increase wages, and mitigate automation’s effects on the labor market. These findings highlight Economocracy’s potential as a viable alternative to traditional economic systems, offering a sustainable pathway that harmonizes growth, social justice, and environmental stewardship in the global economy. Economocracy demonstrates potential to reduce debt per capita by increasing the efficiency of public resource allocation and enhancing average income levels. As EPIs stimulate employment and productivity while EPRs moderate inequality, the resulting economic growth expands the tax base and alleviates fiscal pressures. These dynamics lead to lower per capita debt burdens over time. The analysis is situated within the broader discourse of institutional economics to demonstrate that Economocracy is not merely a policy correction but a new economic system akin to democracy in political life. Full article
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21 pages, 961 KiB  
Article
A Mixed-Method Assessment of Drivers and Barriers for Substituting Dairy with Plant-Based Alternatives by Danish Adults
by Beatriz Philippi Rosane, Lise Tjørring, Annika Ley, Derek Victor Byrne, Barbara Vad Andersen, Susanne Gjedsted Bügel and Sophie Wennerscheid
Foods 2025, 14(15), 2755; https://doi.org/10.3390/foods14152755 - 7 Aug 2025
Abstract
The market for plant-based alternatives to animal foods has increased rapidly in the past decade, mainly due to consumer demand. Little evidence is available regarding nutritional impacts, drivers, and barriers to using these products as substitutes for animal foods in real-life conditions. This [...] Read more.
The market for plant-based alternatives to animal foods has increased rapidly in the past decade, mainly due to consumer demand. Little evidence is available regarding nutritional impacts, drivers, and barriers to using these products as substitutes for animal foods in real-life conditions. This pilot study followed 16 Danish adults (30 ± 11 years old; 11 females) for 4 weeks with substituting milk, cheese, and yogurt with plant-based analogues to dairy (PBADs) and assessed their drivers and barriers to applying the intervention with a mixed-method approach. PBADs are constantly compared to their animal counterparts, both regarding product characteristics, such as price and sensory properties, as well as cultural roles and subjective memories. The mixed methods showed dairy attachment, price, and taste were the main barriers to consuming PBAD, while changes in life and social circles were drivers (qualitative data). As for the liking of PBADs, plant-based yoghurt was the preferred intervention product (73.5/100, p < 0.05), followed by plant-based drinks (65.9/100), while plant-based cheese was the lowest rated (47.9/100, p < 0.05). As for dietary changes, a lower average intake of sugars, saturated fatty acids, cholesterol, calcium, phosphorus, and zinc was observed after the intervention. Additionally, this study describes the attachment of the study population to milk and dairy products. It shows that choosing dairy is beyond nourishment but is connected to tradition, culture, pleasure, memories, and a sense of belonging. In contrast, there is no history or attachment to PBADs. Full article
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18 pages, 860 KiB  
Article
Disruption in Southern Africa’s Money Laundering Activity by Artificial Intelligence Technologies
by Michael Masunda and Haresh Barot
J. Risk Financial Manag. 2025, 18(8), 441; https://doi.org/10.3390/jrfm18080441 - 7 Aug 2025
Abstract
The rise in illicit financial activities across the South Africa–Zimbabwe corridor, with an estimated annual loss of $3.1 billion demands advanced AI solutions to augment traditional detection methods. This study introduces FALCON, a groundbreaking hybrid transformer–GNN model that integrates temporal transaction analysis (TimeGAN) [...] Read more.
The rise in illicit financial activities across the South Africa–Zimbabwe corridor, with an estimated annual loss of $3.1 billion demands advanced AI solutions to augment traditional detection methods. This study introduces FALCON, a groundbreaking hybrid transformer–GNN model that integrates temporal transaction analysis (TimeGAN) and graph-based entity mapping (GraphSAGE) to detect illicit financial flows with unprecedented precision. By leveraging data from South Africa’s FIC, Zimbabwe’s RBZ, and SWIFT, FALCON achieved 98.7%, surpassing Random Forest (72.1%) and human auditors (64.5%), while reducing false positives to 1.2% (AUC-ROC: 0.992). Tested on 1.8 million transactions, including falsified CTRs, STRs, and Ethereum blockchain data, FALCON uncovered $450 million laundered by 23 shell companies with a cross-border detection precision of 94%, directly mitigating illicit financial flows in Southern Africa. For regulators, FALCON met FAFT standards, yielding 92% court admissibility, and its GDPR-compliant design (ε = 1.2 differential privacy) met stringent legal standards. Deployed on AWS Graviton3, FALCON processed 2 million transactions/second at $0.002 per 1000 transactions, demonstrating real-time scalability, making it cost-effective for financial institutions in emerging markets. As the first AI framework tailored for Southern Africa’s financial ecosystems, FALCON sets a new benchmark for ethical AML solutions in emerging economies with immediate applicability to CBDC supervision. The transparent validation of publicly available data underscores its potential to transform global financial crime detection. Full article
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21 pages, 1788 KiB  
Article
Investigation, Prospects, and Economic Scenarios for the Use of Biochar in Small-Scale Agriculture in Tropical
by Vinicius John, Ana Rita de Oliveira Braga, Criscian Kellen Amaro de Oliveira Danielli, Heiriane Martins Sousa, Filipe Eduardo Danielli, Newton Paulo de Souza Falcão, João Guerra, Dimas José Lasmar and Cláudia S. C. Marques-dos-Santos
Agriculture 2025, 15(15), 1700; https://doi.org/10.3390/agriculture15151700 - 6 Aug 2025
Abstract
This study investigates the production and economic feasibility of biochar for smallholder and family farms in Central Amazonia, with potential implications for other tropical regions. The costs of construction of a prototype mobile kiln and biochar production were evaluated, using small-sized biomass from [...] Read more.
This study investigates the production and economic feasibility of biochar for smallholder and family farms in Central Amazonia, with potential implications for other tropical regions. The costs of construction of a prototype mobile kiln and biochar production were evaluated, using small-sized biomass from acai (Euterpe oleracea Mart.) agro-industrial residues as feedstock. The biochar produced was characterised in terms of its liming capacity (calcium carbonate equivalence, CaCO3eq), nutrient content via organic fertilisation methods, and ash analysis by ICP-OES. Field trials with cowpea assessed economic outcomes, as well scenarios of fractional biochar application and cost comparison between biochar production in the prototype kiln and a traditional earth-brick kiln. The prototype kiln showed production costs of USD 0.87–2.06 kg−1, whereas traditional kiln significantly reduced costs (USD 0.03–0.08 kg−1). Biochar application alone increased cowpea revenue by 34%, while combining biochar and lime raised cowpea revenues by up to 84.6%. Owing to high input costs and the low value of the crop, the control treatment generated greater net revenue compared to treatments using lime alone. Moreover, biochar produced in traditional kilns provided a 94% increase in net revenue compared to liming. The estimated externalities indicated that carbon credits represented the most significant potential source of income (USD 2217 ha−1). Finally, fractional biochar application in ten years can retain over 97% of soil carbon content, demonstrating potential for sustainable agriculture and carbon sequestration and a potential further motivation for farmers if integrated into carbon markets. Public policies and technological adaptations are essential for facilitating biochar adoption by small-scale tropical farmers. Full article
(This article belongs to the Special Issue Converting and Recycling of Agroforestry Residues)
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22 pages, 1177 KiB  
Article
An Empirical Study on the Impact of Financial Technology on the Profitability of China’s Listed Commercial Banks
by Xue Yuan, Chin-Hong Puah and Dayang Affizzah binti Awang Marikan
J. Risk Financial Manag. 2025, 18(8), 440; https://doi.org/10.3390/jrfm18080440 - 6 Aug 2025
Abstract
This paper selects 50 listed commercial banks in China from 2012 to 2023 as research samples, and employs the fixed effects model and Hansen’s threshold regression method to systematically examine the impact mechanism and non-linear characteristics of FinTech development on the profitability of [...] Read more.
This paper selects 50 listed commercial banks in China from 2012 to 2023 as research samples, and employs the fixed effects model and Hansen’s threshold regression method to systematically examine the impact mechanism and non-linear characteristics of FinTech development on the profitability of commercial banks. The key findings are summarized as follows: (1) FinTech significantly undermines the overall profitability of commercial banks by reshaping the competitive landscape of the industry and intensifying the technology substitution effect. This is primarily reflected in the reduction in traditional interest income and the erosion of market share in intermediary business. (2) Heterogeneity analysis indicates that large state-owned banks and joint-stock banks experience more pronounced negative impacts compared to small and medium-sized banks. (3) Additional research findings reveal a significant single-threshold effect between FinTech and bank profitability, with a critical value of 4.169. When the development level of FinTech surpasses this threshold, its inhibitory effect diminishes substantially, suggesting that after achieving a certain degree of technological integration, commercial banks may partially alleviate external competitive pressures through synergistic effects. This study offers crucial empirical evidence and theoretical support for commercial banks to develop differentiated technology strategies and for regulatory authorities to design dynamically adaptable policy frameworks. Full article
(This article belongs to the Section Financial Technology and Innovation)
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23 pages, 1191 KiB  
Article
The Power of Interaction: Fan Growth in Livestreaming E-Commerce
by Hangsheng Yang and Bin Wang
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 203; https://doi.org/10.3390/jtaer20030203 - 6 Aug 2025
Abstract
Fan growth serves as a critical performance indicator for the sustainable development of livestreaming e-commerce (LSE). However, existing research has paid limited attention to this topic. This study investigates the unique interactive advantages of LSE over traditional e-commerce by examining how interactivity drives [...] Read more.
Fan growth serves as a critical performance indicator for the sustainable development of livestreaming e-commerce (LSE). However, existing research has paid limited attention to this topic. This study investigates the unique interactive advantages of LSE over traditional e-commerce by examining how interactivity drives fan growth through the mediating role of user retention and the moderating role of anchors’ facial attractiveness. To conduct the analysis, real-time data were collected from 1472 livestreaming sessions on Douyin, China’s leading LSE platform, between January and March 2023, using Python-based (3.12.7) web scraping and third-party data sources. This study operationalizes key variables through text sentiment analysis and image recognition techniques. Empirical analyses are performed using ordinary least squares (OLS) regression with robust standard errors, propensity score matching (PSM), and sensitivity analysis to ensure robustness. The results reveal the following: (1) Interactivity has a significant positive effect on fan growth. (2) User retention partially mediates the relationship between interactivity and fan growth. (3) There is a substitution effect between anchors’ facial attractiveness and interactivity in enhancing user retention, highlighting the substitution relationship between anchors’ personal characteristics and livestreaming room attributes. This research advances the understanding of interactivity’s mechanisms in LSE and, notably, is among the first to explore the marketing implications of anchors’ facial attractiveness in this context. The findings offer valuable insights for both academic research and managerial practice in the evolving livestreaming commerce landscape. Full article
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19 pages, 790 KiB  
Article
How Does the Power Generation Mix Affect the Market Value of US Energy Companies?
by Silvia Bressan
J. Risk Financial Manag. 2025, 18(8), 437; https://doi.org/10.3390/jrfm18080437 - 6 Aug 2025
Abstract
To remain competitive in the decarbonization process of the economy worldwide, energy companies must preserve their market value to attract new investors and remain resilient throughout the transition to net zero. This article examines the market value of US energy companies during the [...] Read more.
To remain competitive in the decarbonization process of the economy worldwide, energy companies must preserve their market value to attract new investors and remain resilient throughout the transition to net zero. This article examines the market value of US energy companies during the period 2012–2024 in relation to their power generation mix. Panel regression analyses reveal that Tobin’s q and price-to-book ratios increase significantly for solar and wind power, while they experience moderate increases for natural gas power. In contrast, Tobin’s q and price-to-book ratios decline for nuclear and coal power. Furthermore, accounting-based profitability, measured by the return on assets (ROA), does not show significant variation with any type of power generation. The findings suggest that market investors prefer solar, wind, and natural gas power generation, thereby attributing greater value (that is, demanding lower risk compensation) to green companies compared to traditional ones. These insights provide guidance to executives, investors, and policy makers on how the power generation mix can influence strategic decisions in the energy sector. Full article
(This article belongs to the Special Issue Linkage Between Energy and Financial Markets)
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18 pages, 425 KiB  
Article
A Clustering Method for Product Cannibalization Detection Using Price Effect
by Lu Xu
Electronics 2025, 14(15), 3120; https://doi.org/10.3390/electronics14153120 - 5 Aug 2025
Abstract
In marketing science, product categorization using cannibalization relationship data is an emerging but still underdeveloped area, where clustering using price effect information is a novel direction that is worth further exploration. In this study, by assuming a realistic modeling of the cross-price effect, [...] Read more.
In marketing science, product categorization using cannibalization relationship data is an emerging but still underdeveloped area, where clustering using price effect information is a novel direction that is worth further exploration. In this study, by assuming a realistic modeling of the cross-price effect, we developed and experimentally validated with simulations an agglomerative clustering algorithm that outputs clustering results closer to the ground truth compared with other agglomerative algorithms based on traditional cluster linkages. Full article
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26 pages, 449 KiB  
Review
The Science of Aging: Understanding Phenolic and Flavor Compounds and Their Influence on Alcoholic Beverages Aged with Alternative Woods
by Tainá Francisca Cordeiro de Souza, Bruna Melo Miranda, Julio Cesar Colivet Briceno, Joaquín Gómez-Estaca and Flávio Alves da Silva
Foods 2025, 14(15), 2739; https://doi.org/10.3390/foods14152739 - 5 Aug 2025
Abstract
Aging in wooden barrels is a proven technique that enhances the sensory complexity of alcoholic beverages by promoting the extraction of volatile and phenolic compounds. While oak has been traditionally used, there is a growing interest in exploring alternative wood species that can [...] Read more.
Aging in wooden barrels is a proven technique that enhances the sensory complexity of alcoholic beverages by promoting the extraction of volatile and phenolic compounds. While oak has been traditionally used, there is a growing interest in exploring alternative wood species that can impart distinct sensory characteristics and promote innovative maturation processes. This review examines the impact of alternative woods on the aging of beverages, such as wine, cachaça, tequila, and beer, focusing on their influence on aroma, flavor, color, and chemical composition. A bibliometric analysis highlights the increasing scientific attention toward wood diversification and emerging aging technologies, including ultrasound and micro-oxygenation, which accelerate maturation while preserving sensory complexity. The role of toasting techniques in modulating the release of phenolic and volatile compounds is also discussed, emphasizing their contribution to unique sensory profiles. Additionally, regulatory aspects and sustainability considerations are explored, suggesting that alternative woods can expand flavor possibilities while supporting environmentally sustainable practices. This review underscores the potential of non-traditional wood species to drive innovation in the aging of alcoholic beverages and provide new sensory experiences that align with evolving consumer preferences and market trends. Full article
(This article belongs to the Section Drinks and Liquid Nutrition)
17 pages, 909 KiB  
Review
Potential of Natural Esters as Immersion Coolant in Electric Vehicles
by Raj Shah, Cindy Huang, Gobinda Karmakar, Sevim Z. Erhan, Majher I. Sarker and Brajendra K. Sharma
Energies 2025, 18(15), 4145; https://doi.org/10.3390/en18154145 - 5 Aug 2025
Viewed by 63
Abstract
As the popularity of electric vehicles (EVs) continues to increase, the need for effective and efficient driveline lubricants and dielectric coolants has become crucial. Commercially used mineral oils or synthetic ester-based coolants, despite performing satisfactorily, are not environmentally friendly. The fatty esters of [...] Read more.
As the popularity of electric vehicles (EVs) continues to increase, the need for effective and efficient driveline lubricants and dielectric coolants has become crucial. Commercially used mineral oils or synthetic ester-based coolants, despite performing satisfactorily, are not environmentally friendly. The fatty esters of vegetable oils, after overcoming their shortcomings (like poor oxidative stability, higher viscosity, and pour point) through chemical modification, have recently been used as potential dielectric coolants in transformers. The benefits of natural esters, including a higher flash point, breakdown voltage, dielectric character, thermal conductivity, and most importantly, readily biodegradable nature, have made them a suitable and sustainable substitute for traditional coolants in electric transformers. Based on their excellent performance in transformers, research on their application as dielectric immersion coolants in modern EVs has been emerging in recent years. This review primarily highlights the beneficial aspects of natural esters performing dual functions—cooling as well as lubricating, which is necessary for “wet” e-motors in EVs—through a comparative study with the commercially used mineral and synthetic coolants. The adoption of natural fatty esters of vegetable oils as an immersion cooling fluid is a significant sustainable step for the battery thermal management system (BTMS) of modern EVs considering environmental safety protocols. Continued research and development are necessary to overcome the ongoing challenges and optimize esters for widespread use in the rapidly expanding electric vehicle market. Full article
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31 pages, 1755 KiB  
Article
Two-Stage Distributionally Robust Optimization for an Asymmetric Loss-Aversion Portfolio via Deep Learning
by Xin Zhang, Shancun Liu and Jingrui Pan
Symmetry 2025, 17(8), 1236; https://doi.org/10.3390/sym17081236 - 4 Aug 2025
Viewed by 122
Abstract
In portfolio optimization, investors often overlook asymmetric preferences for gains and losses. We propose a distributionally robust two-stage portfolio optimization (DR-TSPO) model, which is suitable for scenarios where the loss reference point is adaptively updated based on prior decisions. For analytical convenience, we [...] Read more.
In portfolio optimization, investors often overlook asymmetric preferences for gains and losses. We propose a distributionally robust two-stage portfolio optimization (DR-TSPO) model, which is suitable for scenarios where the loss reference point is adaptively updated based on prior decisions. For analytical convenience, we further reformulate the DR-TSPO model as an equivalent second-order cone programming counterpart. Additionally, we develop a deep learning-based constraint correction algorithm (DL-CCA) trained directly on problem descriptions, which enhances computational efficiency for large-scale non-convex distributionally robust portfolio optimization. Our empirical results obtained using global market data demonstrate that during COVID-19, the DR-TSPO model outperformed traditional two-stage optimization in reducing conservatism and avoiding extreme losses. Full article
(This article belongs to the Section Computer)
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22 pages, 715 KiB  
Article
Research on the Development of the New Energy Vehicle Industry in the Context of ASEAN New Energy Policy
by Yalin Mo, Lu Li and Haihong Deng
Sustainability 2025, 17(15), 7073; https://doi.org/10.3390/su17157073 - 4 Aug 2025
Viewed by 109
Abstract
The green transformation of traditional energy structures and the development of the new energy industry are crucial drivers of sustainable development in the country. The ASEAN Plan of Action for Energy Cooperation (2016–2025; APAEC [2016–2025]), established in 2016, has significantly promoted the growth [...] Read more.
The green transformation of traditional energy structures and the development of the new energy industry are crucial drivers of sustainable development in the country. The ASEAN Plan of Action for Energy Cooperation (2016–2025; APAEC [2016–2025]), established in 2016, has significantly promoted the growth of the new energy sector and enhanced energy structures across Association of Southeast Asian Nations (ASEAN). This initiative has also inspired these countries to develop corresponding industrial policies aimed at supporting the new energy vehicle (NEV) industry, resulting in significant growth in this sector within the ASEAN region. This paper analyzes the factors influencing the development of the NEV industry in the context of ASEAN’s new energy policies, drawing empirical insights from data collected across six ASEAN countries from 2013 to 2024. Following the implementation of the APAEC (2016–2025), it was observed that ASEAN countries reached a consensus on energy development and cooperation, collaboratively advancing the NEV industry through regional policies. Furthermore, factors such as national governance, financial development, education levels, and the size of the automotive market positively contribute to the growth of the NEV industry in ASEAN. Conversely, high energy consumption can hinder its progress. Additionally, further research indicates that the APAEC (2016–2025) has exerted a more pronounced impact on countries with robust automotive industry foundations or those prioritizing relevant policies. The findings of this paper offer valuable insights for ASEAN countries in the formulating policies for the NEV industry, optimizing energy structures, and achieving low-carbon energy transition and sustainable development. Full article
(This article belongs to the Section Energy Sustainability)
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36 pages, 1202 KiB  
Article
Exploring Service Needs and Development Strategies for the Healthcare Tourism Industry Through the APA-NRM Technique
by Chung-Ling Kuo and Chia-Li Lin
Sustainability 2025, 17(15), 7068; https://doi.org/10.3390/su17157068 - 4 Aug 2025
Viewed by 91
Abstract
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism [...] Read more.
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism and medical services, which is health tourism. This growing demand has prompted many service providers to see it as a business opportunity and enter the market. Tourism can help travelers release work stress and restore physical and mental balance; meanwhile, health check-ups and disease treatment can help them regain health. Consumers have long favored health and medical tourism because it helps relieve stress and promotes overall well-being. As people age, some consumers experience a gradual decline in physical functions, making it difficult for them to participate in regular travel services provided by traditional travel agencies. Therefore, this study aims to explore the service needs of health and medical tourism customers (tourists/patients) and the interrelationships among these service needs, so that health and medical tourism service providers can develop more customized and diversified services. This study identifies four key drivers of medical tourism services: medical services, medical facilities, tour planning, and hospitality facilities. This study uses the APA (attention and performance analysis) method to assess each dimension and criterion and utilizes the DEMATEL method with the NRM (network relationship map) to identify network relationships. By combining APA and NRM techniques, this study develops the APA-NRM technique to evaluate adoption strategies and identify suitable paths for health tourism services, providing tailored development strategies and recommendations for service providers to enhance the service experience. Full article
(This article belongs to the Special Issue Inclusive Tourism and Its Place in Sustainable Development Concepts)
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32 pages, 944 KiB  
Review
Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation
by Sarfaraz K. Niazi
Pharmaceuticals 2025, 18(8), 1157; https://doi.org/10.3390/ph18081157 - 4 Aug 2025
Viewed by 517
Abstract
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for Harmonization (ICH) Q13 guidance and compelling economic advantages. This comprehensive review examines the [...] Read more.
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for Harmonization (ICH) Q13 guidance and compelling economic advantages. This comprehensive review examines the technical, economic, and regulatory aspects of implementing continuous manufacturing specifically for recombinant protein production and biosimilar development, synthesizing validated data from peer-reviewed research, regulatory sources, and global implementation case studies. The analysis demonstrates that continuous manufacturing offers substantial benefits, including a reduced equipment footprint of up to 70%, a 3- to 5-fold increase in volumetric productivity, enhanced product quality consistency, and facility cost reductions of 30–50% compared to traditional batch processes. Leading biomanufacturers across North America, Europe, and the Asia–Pacific region are successfully integrating perfusion upstream processes with connected downstream bioprocesses, enabling the fully end-to-end continuous manufacture of biopharmaceuticals with demonstrated commercial viability. The regulatory framework has been comprehensively established through ICH Q13 guidance and region-specific implementations across the FDA, EMA, PMDA, and emerging market authorities. This review provides a critical analysis of advanced technologies, including single-use perfusion bioreactors, continuous chromatography systems, real-time process analytical technology, and Industry 4.0 integration strategies. The economic modeling presents favorable return-on-investment profiles, accompanied by a detailed analysis of global market dynamics, regional implementation patterns, and supply chain integration opportunities. Full article
(This article belongs to the Section Pharmaceutical Technology)
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