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Search Results (2,278)

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18 pages, 3354 KiB  
Article
Hydrological Modeling of the Chikugo River Basin Using SWAT: Insights into Water Balance and Seasonal Variability
by Francis Jhun Macalam, Kunyang Wang, Shin-ichi Onodera, Mitsuyo Saito, Yuko Nagano, Masatoshi Yamazaki and Yu War Nang
Sustainability 2025, 17(15), 7027; https://doi.org/10.3390/su17157027 (registering DOI) - 2 Aug 2025
Abstract
Integrated hydrological modeling plays a crucial role in advancing sustainable water resource management, particularly in regions facing seasonal and extreme precipitation events. However, comprehensive studies that assess hydrological variability in temperate river basins remain limited. This study addresses this gap by evaluating the [...] Read more.
Integrated hydrological modeling plays a crucial role in advancing sustainable water resource management, particularly in regions facing seasonal and extreme precipitation events. However, comprehensive studies that assess hydrological variability in temperate river basins remain limited. This study addresses this gap by evaluating the performance of the Soil and Water Assessment Tool (SWAT) in simulating streamflow, water balance, and seasonal hydrological dynamics in the Chikugo River Basin, Kyushu Island, Japan. The basin, originating from Mount Aso and draining into the Ariake Sea, is subject to frequent typhoons and intense rainfall, making it a critical case for sustainable water governance. Using the Sequential Uncertainty Fitting Version 2 (SUFI-2) approach, we calibrated the SWAT model over the period 20072–2021. Water balance analysis revealed that baseflow plays dominant roles in basin hydrology which is essential for agricultural and domestic water needs by providing a stable groundwater contribution despite increasing precipitation and varying water demand. These findings contribute to a deeper understanding of hydrological behavior in temperate catchments and offer a scientific foundation for sustainable water allocation, planning, and climate resilience strategies. Full article
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25 pages, 5388 KiB  
Article
Numerical and Experimental Evaluation of Axial Load Transfer in Deep Foundations Within Stratified Cohesive Soils
by Şahin Çaglar Tuna
Buildings 2025, 15(15), 2723; https://doi.org/10.3390/buildings15152723 (registering DOI) - 1 Aug 2025
Abstract
This study presents a numerical and experimental evaluation of axial load transfer mechanisms in deep foundations constructed in stratified cohesive soils in İzmir, Türkiye. A full-scale bi-directional static load test equipped with strain gauges was conducted on a barrette pile to investigate depth-dependent [...] Read more.
This study presents a numerical and experimental evaluation of axial load transfer mechanisms in deep foundations constructed in stratified cohesive soils in İzmir, Türkiye. A full-scale bi-directional static load test equipped with strain gauges was conducted on a barrette pile to investigate depth-dependent mobilization of shaft resistance. A finite element model was developed and calibrated using field-observed load–settlement and strain data to replicate the pile–soil interaction and deformation behavior. The analysis revealed a shaft-dominated load transfer behavior, with progressive mobilization concentrated in intermediate-depth cohesive layers. Sensitivity analysis identified the undrained stiffness (Eu) as the most influential parameter governing pile settlement. A strong polynomial correlation was established between calibrated Eu values and SPT N60, offering a practical tool for preliminary design. Additionally, strain energy distribution was evaluated as a supplementary metric, enhancing the interpretation of mobilization zones beyond conventional stress-based methods. The integrated approach provides valuable insights for performance-based foundation design in layered cohesive ground, supporting the development of site-calibrated numerical models informed by full-scale testing data. Full article
(This article belongs to the Section Building Structures)
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20 pages, 3027 KiB  
Article
Evolutionary Game Analysis of Multi-Agent Synergistic Incentives Driving Green Energy Market Expansion
by Yanping Yang, Xuan Yu and Bojun Wang
Sustainability 2025, 17(15), 7002; https://doi.org/10.3390/su17157002 (registering DOI) - 1 Aug 2025
Abstract
Achieving the construction sector’s dual carbon objectives necessitates scaling green energy adoption in new residential buildings. The current literature critically overlooks four unresolved problems: oversimplified penalty mechanisms, ignoring escalating regulatory costs; static subsidies misaligned with market maturity evolution; systematic exclusion of innovation feedback [...] Read more.
Achieving the construction sector’s dual carbon objectives necessitates scaling green energy adoption in new residential buildings. The current literature critically overlooks four unresolved problems: oversimplified penalty mechanisms, ignoring escalating regulatory costs; static subsidies misaligned with market maturity evolution; systematic exclusion of innovation feedback from energy suppliers; and underexplored behavioral evolution of building owners. This study establishes a government–suppliers–owners evolutionary game framework with dynamically calibrated policies, simulated using MATLAB multi-scenario analysis. Novel findings demonstrate: (1) A dual-threshold penalty effect where excessive fines diminish policy returns due to regulatory costs, requiring dynamic calibration distinct from fixed-penalty approaches; (2) Market-maturity-phased subsidies increasing owner adoption probability by 30% through staged progression; (3) Energy suppliers’ cost-reducing innovations as pivotal feedback drivers resolving coordination failures, overlooked in prior tripartite models; (4) Owners’ adoption motivation shifts from short-term economic incentives to environmentally driven decisions under policy guidance. The framework resolves these gaps through integrated dynamic mechanisms, providing policymakers with evidence-based regulatory thresholds, energy suppliers with cost-reduction targets, and academia with replicable modeling tools. Full article
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32 pages, 15216 KiB  
Article
Leveraging Soil Geography for Land Use Planning: Assessing and Mapping Soil Ecosystem Services Indicators in Emilia-Romagna, NE Italy
by Fabrizio Ungaro, Paola Tarocco and Costanza Calzolari
Geographies 2025, 5(3), 39; https://doi.org/10.3390/geographies5030039 (registering DOI) - 1 Aug 2025
Abstract
An indicator-based approach was implemented to assess the contributions of soils in supplying ecosystem services, providing a scalable tool for modeling the spatial heterogeneity of soil functions at regional and local scales. The method consisted of (i) the definition of soil-based ecosystem services [...] Read more.
An indicator-based approach was implemented to assess the contributions of soils in supplying ecosystem services, providing a scalable tool for modeling the spatial heterogeneity of soil functions at regional and local scales. The method consisted of (i) the definition of soil-based ecosystem services (SESs), using available point data and thematic maps; (ii) the definition of appropriate SES indicators; (iii) the assessment and mapping of potential SESs provision for the Emilia-Romagna region (22.510 km2) in NE Italy. Depending on data availability and on the role played by terrain features and soil geography and its complexity, maps of basic soil characteristics (textural fractions, organic C content, and pH) covering the entire regional territory were produced at a 1 ha resolution using digital soil mapping techniques and geostatistical simulations to explicitly consider spatial variability. Soil physical properties such as bulk density, porosity, and hydraulic conductivity at saturation were derived using pedotransfer functions calibrated using local data and integrated with supplementary information such as land capability and remote sensing indices to derive the inputs for SES assessment. Eight SESs were mapped at 1:50,000 reference scale: buffering capacity, carbon sequestration, erosion control, food provision, biomass provision, water regulation, water storage, and habitat for soil biodiversity. The results are discussed and compared for the different pedolandscapes, identifying clear spatial patterns of soil functions and potential SES supply. Full article
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40 pages, 6841 KiB  
Article
Distributionally Robust Multivariate Stochastic Cone Order Portfolio Optimization: Theory and Evidence from Borsa Istanbul
by Larissa Margerata Batrancea, Mehmet Ali Balcı, Ömer Akgüller and Lucian Gaban
Mathematics 2025, 13(15), 2473; https://doi.org/10.3390/math13152473 - 31 Jul 2025
Abstract
We introduce a novel portfolio optimization framework—Distributionally Robust Multivariate Stochastic Cone Order (DR-MSCO)—which integrates partial orders on random vectors with Wasserstein-metric ambiguity sets and adaptive cone structures to model multivariate investor preferences under distributional uncertainty. Grounded in measure theory and convex analysis, DR-MSCO [...] Read more.
We introduce a novel portfolio optimization framework—Distributionally Robust Multivariate Stochastic Cone Order (DR-MSCO)—which integrates partial orders on random vectors with Wasserstein-metric ambiguity sets and adaptive cone structures to model multivariate investor preferences under distributional uncertainty. Grounded in measure theory and convex analysis, DR-MSCO employs data-driven cone selection calibrated to market regimes, along with coherent tail-risk operators that generalize Conditional Value-at-Risk to the multivariate setting. We derive a tractable second-order cone programming reformulation and demonstrate statistical consistency under empirical ambiguity sets. Empirically, we apply DR-MSCO to 23 Borsa Istanbul equities from 2021–2024, using a rolling estimation window and realistic transaction costs. Compared to classical mean–variance and standard distributionally robust benchmarks, DR-MSCO achieves higher overall and crisis-period Sharpe ratios (2.18 vs. 2.09 full sample; 0.95 vs. 0.69 during crises), reduces maximum drawdown by 10%, and yields endogenous diversification without exogenous constraints. Our results underscore the practical benefits of combining multivariate preference modeling with distributional robustness, offering institutional investors a tractable tool for resilient portfolio construction in volatile emerging markets. Full article
(This article belongs to the Special Issue Modern Trends in Mathematics, Probability and Statistics for Finance)
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23 pages, 2554 KiB  
Article
Modeling the Higher Heating Value of Spanish Biomass via Neural Networks and Analytical Equations
by Anbarasan Jayapal, Fernando Ordonez Morales, Muhammad Ishtiaq, Se Yun Kim and Nagireddy Gari Subba Reddy
Energies 2025, 18(15), 4067; https://doi.org/10.3390/en18154067 (registering DOI) - 31 Jul 2025
Abstract
Accurate estimation of biomass higher heating value (HHV) is crucial for designing efficient bioenergy systems. In this study, we developed a Backpropagation artificial neural network (ANN) that predicts HHV from routine proximate/ultimate composition data. The network (9-6-6-1 architecture, trained for 15,000 epochs with [...] Read more.
Accurate estimation of biomass higher heating value (HHV) is crucial for designing efficient bioenergy systems. In this study, we developed a Backpropagation artificial neural network (ANN) that predicts HHV from routine proximate/ultimate composition data. The network (9-6-6-1 architecture, trained for 15,000 epochs with learning rate 0.3 and momentum 0.4) was calibrated on 99 diverse Spanish biomass samples (inputs: moisture, ash, volatile matter, fixed carbon, C, H, O, N, S). The optimized ANN achieved strong predictive accuracy (validation R2 ≈ 0.81; mean squared error ≈ 1.33 MJ/kg; MAE ≈ 0.77 MJ/kg), representing a substantial improvement over 54 analytical models despite the known complexity and variability of biomass composition. Importantly, in direct comparisons it significantly outperformed 54 published analytical HHV correlations—the ANN achieved substantially higher R2 and lower prediction error than any fixed-form formula in the literature. A sensitivity analysis confirmed chemically intuitive trends (higher C/H/FC increase HHV; higher moisture/ash/O reduce it), indicating the model learned meaningful fuel-property relationships. The ANN thus provided a computationally efficient and robust tool for rapid, accurate HHV estimation from compositional data. Future work will expand the dataset, incorporate thermal pretreatment effects, and integrate the model into a user-friendly decision-support platform for bioenergy applications. Full article
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13 pages, 2435 KiB  
Article
Preliminary Evaluation of Spherical Over-Refraction Measurement Using a Smartphone
by Rosa Maria Salmeron-Campillo, Gines Martinez-Ros, Jose Angel Diaz-Guirado, Tania Orenes-Nicolas, Mateusz Jaskulski and Norberto Lopez-Gil
Photonics 2025, 12(8), 772; https://doi.org/10.3390/photonics12080772 (registering DOI) - 31 Jul 2025
Viewed by 58
Abstract
Background: Smartphones offer a promising tool for monitoring refractive error, especially in underserved areas where there is a shortage of eye-care professionals. We propose a novel method for measuring spherical over-refraction using smartphones. Methods: Specific levels of myopia using positive spherical trial lenses, [...] Read more.
Background: Smartphones offer a promising tool for monitoring refractive error, especially in underserved areas where there is a shortage of eye-care professionals. We propose a novel method for measuring spherical over-refraction using smartphones. Methods: Specific levels of myopia using positive spherical trial lenses, ranging from 0.00 D to 1.50 D in 0.25 D increments, were induced in 30 young participants (22 ± 5 years). A comparison was conducted between the induced over-refraction and the measurements obtained using a non-commercial mobile application based on the face–device distance measurement using the front camera while the subject was performing a resolution task. Results: Calibrated mobile app over-refraction results showed that 89.5% of the estimates had an error ≤ 0.25 D, and no errors exceeding 0.50 D. Bland–Altman analysis revealed no significant bias between app and clinical over-refraction, with a mean difference of 0.00 D ± 0.44 D (p = 0.981), indicating high accuracy and precision of the method. Conclusions: The methodology used shows high accuracy and precision in the measurement of the spherical over-refraction with only the use of a smartphone, allowing self-monitorization of potential myopia progression. Full article
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14 pages, 2727 KiB  
Article
A Multimodal MRI-Based Model for Colorectal Liver Metastasis Prediction: Integrating Radiomics, Deep Learning, and Clinical Features with SHAP Interpretation
by Xin Yan, Furui Duan, Lu Chen, Runhong Wang, Kexin Li, Qiao Sun and Kuang Fu
Curr. Oncol. 2025, 32(8), 431; https://doi.org/10.3390/curroncol32080431 - 30 Jul 2025
Viewed by 86
Abstract
Purpose: Predicting colorectal cancer liver metastasis (CRLM) is essential for prognostic assessment. This study aims to develop and validate an interpretable multimodal machine learning framework based on multiparametric MRI for predicting CRLM, and to enhance the clinical interpretability of the model through [...] Read more.
Purpose: Predicting colorectal cancer liver metastasis (CRLM) is essential for prognostic assessment. This study aims to develop and validate an interpretable multimodal machine learning framework based on multiparametric MRI for predicting CRLM, and to enhance the clinical interpretability of the model through SHapley Additive exPlanations (SHAP) analysis and deep learning visualization. Methods: This multicenter retrospective study included 463 patients with pathologically confirmed colorectal cancer from two institutions, divided into training (n = 256), internal testing (n = 111), and external validation (n = 96) sets. Radiomics features were extracted from manually segmented regions on axial T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI). Deep learning features were obtained from a pretrained ResNet101 network using the same MRI inputs. A least absolute shrinkage and selection operator (LASSO) logistic regression classifier was developed for clinical, radiomics, deep learning, and combined models. Model performance was evaluated by AUC, sensitivity, specificity, and F1-score. SHAP was used to assess feature contributions, and Grad-CAM was applied to visualize deep feature attention. Results: The combined model integrating features across the three modalities achieved the highest performance across all datasets, with AUCs of 0.889 (training), 0.838 (internal test), and 0.822 (external validation), outperforming single-modality models. Decision curve analysis (DCA) revealed enhanced clinical net benefit from the integrated model, while calibration curves confirmed its good predictive consistency. SHAP analysis revealed that radiomic features related to T2WI texture (e.g., LargeDependenceLowGrayLevelEmphasis) and clinical biomarkers (e.g., CA19-9) were among the most predictive for CRLM. Grad-CAM visualizations confirmed that the deep learning model focused on tumor regions consistent with radiological interpretation. Conclusions: This study presents a robust and interpretable multiparametric MRI-based model for noninvasively predicting liver metastasis in colorectal cancer patients. By integrating handcrafted radiomics and deep learning features, and enhancing transparency through SHAP and Grad-CAM, the model provides both high predictive performance and clinically meaningful explanations. These findings highlight its potential value as a decision-support tool for individualized risk assessment and treatment planning in the management of colorectal cancer. Full article
(This article belongs to the Section Gastrointestinal Oncology)
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25 pages, 2761 KiB  
Article
Leveraging Deep Learning, Grid Search, and Bayesian Networks to Predict Distant Recurrence of Breast Cancer
by Xia Jiang, Yijun Zhou, Alan Wells and Adam Brufsky
Cancers 2025, 17(15), 2515; https://doi.org/10.3390/cancers17152515 - 30 Jul 2025
Viewed by 179
Abstract
Background: Unlike most cancers, breast cancer poses a persistent risk of distant recurrence—often years after initial treatment—making long-term risk stratification uniquely challenging. Current tools fall short in predicting late metastatic events, particularly for early-stage patients. Methods: We present an interpretable machine [...] Read more.
Background: Unlike most cancers, breast cancer poses a persistent risk of distant recurrence—often years after initial treatment—making long-term risk stratification uniquely challenging. Current tools fall short in predicting late metastatic events, particularly for early-stage patients. Methods: We present an interpretable machine learning (ML) pipeline to predict distant recurrence-free survival at 5, 10, and 15 years, integrating Bayesian network-based causal feature selection, deep feed-forward neural network models (DNMs), and SHAP-based interpretation. Using electronic health record (EHR)-based clinical data from over 6000 patients, we first applied the Markov blanket and interactive risk factor learner (MBIL) to identify minimally sufficient predictor subsets. These were then used to train optimized DNM classifiers, with hyperparameters tuned via grid search and benchmarked against models from 10 traditional ML methods and models trained using all predictors. Results: Our best models achieved area under the curve (AUC) scores of 0.79, 0.83, and 0.89 for 5-, 10-, and 15-year predictions, respectively—substantially outperforming baselines. MBIL reduced input dimensionality by over 80% without sacrificing accuracy. Importantly, MBIL-selected features (e.g., nodal status, hormone receptor expression, tumor size) overlapped strongly with top SHAP contributors, reinforcing interpretability. Calibration plots further demonstrated close agreement between predicted probabilities and observed recurrence rates. The percentage performance improvement due to grid search ranged from 25.3% to 60%. Conclusions: This study demonstrates that combining causal selection, deep learning, and grid search improves prediction accuracy, transparency, and calibration for long-horizon breast cancer recurrence risk. The proposed framework is well-positioned for clinical use, especially to guide long-term follow-up and therapy decisions in early-stage patients. Full article
(This article belongs to the Special Issue AI-Based Applications in Cancers)
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13 pages, 777 KiB  
Article
Nomogram Development and Feature Selection Strategy Comparison for Predicting Surgical Site Infection After Lower Extremity Fracture Surgery
by Humam Baki and Atilla Sancar Parmaksızoğlu
Medicina 2025, 61(8), 1378; https://doi.org/10.3390/medicina61081378 - 30 Jul 2025
Viewed by 142
Abstract
Background and Objectives: Surgical site infections (SSIs) are a frequent complication after lower extremity fracture surgery, yet tools for individualized risk prediction remain limited. This study aimed to develop and internally validate a nomogram for individualized SSI risk prediction based on perioperative [...] Read more.
Background and Objectives: Surgical site infections (SSIs) are a frequent complication after lower extremity fracture surgery, yet tools for individualized risk prediction remain limited. This study aimed to develop and internally validate a nomogram for individualized SSI risk prediction based on perioperative clinical parameters. Materials and Methods: This retrospective cohort study included adults who underwent lower extremity fracture surgery between 2022 and 2025 at a tertiary care center. Thirty candidate predictors were evaluated. Feature selection was performed using six strategies, and the final model was developed with logistic regression based on bootstrap inclusion frequency. Model performance was assessed by area under the curve, calibration slope, Brier score, sensitivity, and specificity. Results: Among 638 patients undergoing lower extremity fracture surgery, 76 (11.9%) developed SSIs. Of six feature selection strategies compared, bootstrap inclusion frequency identified seven predictors: red blood cell count, preoperative C-reactive protein, chronic kidney disease, operative time, chronic obstructive pulmonary disease, body mass index, and blood transfusion. The final model demonstrated an AUROC of 0.924 (95% CI, 0.876–0.973), a calibration slope of 1.03, and a Brier score of 0.0602. Sensitivity was 86.2% (95% CI, 69.4–94.5) and specificity was 89.5% (95% CI, 83.8–93.3). Chronic kidney disease (OR, 88.75; 95% CI, 5.51–1428.80) and blood transfusion (OR, 85.07; 95% CI, 11.69–619.09) were the strongest predictors of infection. Conclusions: The developed nomogram demonstrates strong predictive performance and may support personalized SSI risk assessment in patients undergoing lower extremity fracture surgery. Full article
(This article belongs to the Special Issue Evaluation, Management, and Outcomes in Perioperative Medicine)
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15 pages, 2006 KiB  
Article
Hydrological Responses to Territorial Spatial Change in the Xitiaoxi River Basin: A Simulation Study Using the SWAT Model Driven by China Meteorological Assimilation Driving Datasets
by Dongyan Kong, Huiguang Chen and Kongsen Wu
Water 2025, 17(15), 2267; https://doi.org/10.3390/w17152267 - 30 Jul 2025
Viewed by 185
Abstract
The use of the Soil and Water Assessment Tool (SWAT) model driven by China Meteorological Assimilation Driving Datasets (CMADS) for runoff simulation research is of great significance for regional flood prevention and control. Therefore, from the perspective of production-living-ecological space, this article combined [...] Read more.
The use of the Soil and Water Assessment Tool (SWAT) model driven by China Meteorological Assimilation Driving Datasets (CMADS) for runoff simulation research is of great significance for regional flood prevention and control. Therefore, from the perspective of production-living-ecological space, this article combined multi-source data such as DEM, soil texture and land use type, in order to construct scenarios of territorial spatial change (TSC) across distinct periods. Based on the CMADS-L40 data and the SWAT model, it simulated the runoff dynamics in the Xitiaoxi River Basin, and analyzed the hydrological response characteristics under different TSCs. The results showed that The SWAT model, driven by CMADS-L40 data, demonstrated robust performance in monthly runoff simulation. The coefficient of determination (R2), Nash–Sutcliffe efficiency coefficient (NSE), and the absolute value of percentage bias (|PBIAS|) during the calibration and validation period all met the accuracy requirements of the model, which validated the applicability of CMADS-L40 data and the SWAT model for runoff simulation at the watershed scale. Changes in territorial spatial patterns are closely correlated with runoff variation. Changes in agricultural production space and forest ecological space show statistically significant negative correlation with runoff change, while industrial production space change exhibits a significant positive correlation with runoff change. The expansion of production space, particularly industrial production space, leads to increased runoff, whereas the enlargement of agricultural production space and forest ecological space can reduce runoff. This article contributes to highlighting the role of land use policy in hydrological regulation, providing a scientific basis for optimizing territorial spatial planning to mitigate flood risks and protect water resources. Full article
(This article belongs to the Topic Natural Hazards and Disaster Risks Reduction, 2nd Edition)
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23 pages, 3075 KiB  
Article
Building an Agent-Based Simulation Framework of Smartphone Reuse and Recycling: Integrating Privacy Concern and Behavioral Norms
by Wenbang Hou, Dingjie Peng, Jianing Chu, Yuelin Jiang, Yu Chen and Feier Chen
Sustainability 2025, 17(15), 6885; https://doi.org/10.3390/su17156885 - 29 Jul 2025
Viewed by 140
Abstract
The rapid proliferation of electronic waste, driven by the short lifecycle of smartphones and planned obsolescence strategies, presents escalating global environmental challenges. To address these issues from a systems perspective, this study develops an agent-based modeling (ABM) framework that simulates consumer decisions and [...] Read more.
The rapid proliferation of electronic waste, driven by the short lifecycle of smartphones and planned obsolescence strategies, presents escalating global environmental challenges. To address these issues from a systems perspective, this study develops an agent-based modeling (ABM) framework that simulates consumer decisions and stakeholder interactions within the smartphone reuse and recycling ecosystem. The model incorporates key behavioral drivers—privacy concerns, moral norms, and financial incentives—to examine how social and economic factors shape consumer behavior. Four primary agent types—consumers, manufacturers, recyclers, and second-hand retailers—are modeled to capture complex feedback and market dynamics. Calibrated using empirical data from Jiangsu Province, China, the simulation reveals a dominant consumer tendency to store obsolete smartphones rather than engage in reuse or formal recycling. However, the introduction of government subsidies significantly shifts behavior, doubling participation in second-hand markets and markedly improving recycling rates. These results highlight the value of integrating behavioral insights into environmental modeling to inform circular economy strategies. By offering a flexible and behaviorally grounded simulation tool, this study supports the design of more effective policies for promoting responsible smartphone disposal and lifecycle extension. Full article
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37 pages, 1520 KiB  
Article
Comparative Analysis of Machine and Deep Learning Algorithms for Bragg Peak Estimation in Polymeric Materials for Tissue-Sparing Radiotherapy
by Koray Acici
Polymers 2025, 17(15), 2068; https://doi.org/10.3390/polym17152068 - 29 Jul 2025
Viewed by 180
Abstract
Proton therapy has emerged as a highly precise and tissue-sparing radiotherapy technique, capitalizing on the unique energy deposition pattern of protons characterized by the Bragg peak. Ensuring treatment accuracy relies on calibration phantoms, often composed of tissue-equivalent polymeric materials. This study investigates the [...] Read more.
Proton therapy has emerged as a highly precise and tissue-sparing radiotherapy technique, capitalizing on the unique energy deposition pattern of protons characterized by the Bragg peak. Ensuring treatment accuracy relies on calibration phantoms, often composed of tissue-equivalent polymeric materials. This study investigates the dosimetric behavior of four commonly used polymers—Parylene, Epoxy, Lexan, and Mylar—by analyzing their linear energy transfer (LET) values and Bragg curve characteristics across various proton energies. Experimental LET data were collected and used to train and evaluate the predictive power for Bragg peak of multiple artificial intelligence models, including kNN, SVR, MLP, RF, LWRF, XGBoost, 1D-CNN, LSTM, and BiLSTM. These algorithms were optimized using 10-fold cross-validation and assessed through statistical error and performance metrics including MAE, RAE, RMSE, RRSE, CC, and R2. Results demonstrate that certain AI models, particularly RF and LWRF, accurately (in terms of all evaluation metrics) predict Bragg peaks in Epoxy polymers, reducing the reliance on costly and time-consuming simulations. In terms of CC and R2 metrics, the LWRF model demonstrated superior performance, achieving scores of 0.9969 and 0.9938, respectively. However, when evaluated against MAE, RMSE, RAE, and RRSE metrics, the RF model emerged as the top performer, yielding values of 12.3161, 15.8223, 10.3536, and 11.4389, in the same order. Additionally, the SVR model achieved the highest number of statistically significant differences when compared pairwise with the other eight models, showing significance against six of them. The findings support the use of AI as a robust tool for designing reliable calibration phantoms and optimizing proton therapy planning. This integrative approach enhances the synergy between materials science, medical physics, and data-driven modeling in advanced radiotherapy systems. Full article
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14 pages, 2191 KiB  
Article
AI-Based Ultrasound Nomogram for Differentiating Invasive from Non-Invasive Breast Cancer Masses
by Meng-Yuan Tsai, Zi-Han Yu and Chen-Pin Chou
Cancers 2025, 17(15), 2497; https://doi.org/10.3390/cancers17152497 - 29 Jul 2025
Viewed by 152
Abstract
Purpose: This study aimed to develop a predictive nomogram integrating AI-based BI-RADS lexicons and lesion-to-nipple distance (LND) ultrasound features to differentiate mass-type ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) visible on ultrasound. Methods: The final study cohort consisted of 170 [...] Read more.
Purpose: This study aimed to develop a predictive nomogram integrating AI-based BI-RADS lexicons and lesion-to-nipple distance (LND) ultrasound features to differentiate mass-type ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) visible on ultrasound. Methods: The final study cohort consisted of 170 women with 175 pathologically confirmed malignant breast lesions, including 26 cases of DCIS and 149 cases of IDC. LND and AI-based features from the S-Detect system (BI-RADS lexicons) were analyzed. Rare features were consolidated into broader categories to enhance model stability. Data were split into training (70%) and validation (30%) sets. Logistic regression identified key predictors for an LND nomogram. Model performance was evaluated using receiver operating characteristic (ROC) curves, 1000 bootstrap resamples, and calibration curves to assess discrimination and calibration. Results: Multivariate logistic regression identified smaller lesion size, irregular shape, LND ≤ 3 cm, and non-hypoechoic echogenicity as independent predictors of DCIS. These variables were integrated into the LND nomogram, which demonstrated strong discriminative performance (AUC = 0.851 training; AUC = 0.842 validation). Calibration was excellent, with non-significant Hosmer-Lemeshow tests (p = 0.127 training, p = 0.972 validation) and low mean absolute errors (MAE = 0.016 and 0.034, respectively), supporting the model’s accuracy and reliability. Conclusions: The AI-based comprehensive nomogram demonstrates strong reliability in distinguishing mass-type DCIS from IDC, offering a practical tool to enhance non-invasive breast cancer diagnosis and inform preoperative planning. Full article
(This article belongs to the Section Methods and Technologies Development)
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20 pages, 9605 KiB  
Article
Future Modeling of Urban Growth Using Geographical Information Systems and SLEUTH Method: The Case of Sanliurfa
by Songül Naryaprağı Gülalan, Fred Barış Ernst and Abdullah İzzeddin Karabulut
Sustainability 2025, 17(15), 6833; https://doi.org/10.3390/su17156833 (registering DOI) - 28 Jul 2025
Viewed by 348
Abstract
This study was conducted using Geographic Information Systems (GISs), Remote Sensing (RS) techniques, and the SLEUTH model based on Cellular Automata (CA) to analyze the spatial and temporal dynamics of urban growth in Sanliurfa Province and to create future projections. The model in [...] Read more.
This study was conducted using Geographic Information Systems (GISs), Remote Sensing (RS) techniques, and the SLEUTH model based on Cellular Automata (CA) to analyze the spatial and temporal dynamics of urban growth in Sanliurfa Province and to create future projections. The model in question simulates urban sprawl by using Slope, Land Use/Land Cover (LULC), Excluded Areas, urban areas, transportation, and hill shade layers as inputs. In addition, disaster risk areas and public policies that will affect the urbanization of the city were used as input layers. In the study, the spatial pattern of urbanization in Sanliurfa was determined by using Landsat satellite images of six different periods covering the years 1985–2025. The Analytical Hierarchy Process (AHP) method was applied within the scope of Multi-Criteria Decision Analysis (MCDA). Weighting was made for each parameter. Spatial analysis was performed by combining these values with data in raster format. The results show that the SLEUTH model successfully reflects past growth trends when calibrated at different spatial resolutions and can provide reliable predictions for the future. Thus, the proposed model can be used as an effective decision support tool in the evaluation of alternative urbanization scenarios in urban planning. The findings contribute to the sustainability of land management policies. Full article
(This article belongs to the Special Issue Advanced Studies in Sustainable Urban Planning and Urban Development)
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