Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (1,054)

Search Parameters:
Keywords = time-slicing

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
23 pages, 2056 KB  
Article
Modeling the Evolution of AI Identity Using Structural Features and Temporal Role Dynamics in Complex Networks
by Yahui Lu, Raihanah Mhod Mydin and Ravichandran Vengadasamy
Mathematics 2025, 13(20), 3315; https://doi.org/10.3390/math13203315 - 17 Oct 2025
Abstract
In increasingly networked environments, artificial agents are required to operate not with fixed roles but with identities that adapt, evolve, and emerge through interaction. Traditional identity modeling approaches, whether symbolic or statistical, fail to capture this dynamic, relational nature. This paper proposes a [...] Read more.
In increasingly networked environments, artificial agents are required to operate not with fixed roles but with identities that adapt, evolve, and emerge through interaction. Traditional identity modeling approaches, whether symbolic or statistical, fail to capture this dynamic, relational nature. This paper proposes a network-based framework for constructing and analyzing AI identity by modeling interaction, representation, and emergence within complex networks. The goal is to uncover how agent identity can be inferred and explained through structural roles, temporal behaviors, and community dynamics. The approach begins by transforming raw data from three benchmark domain, Reddit, the Interaction Network dataset, and AMine, into temporal interaction graphs. These graphs are structurally enriched via motif extraction, centrality scoring, and community detection. Graph Neural Networks (GNNs), including GCNs, GATs, and GraphSAGE, are applied to learn identity embeddings across time slices. Extensive evaluations include identity coherence, role classification accuracy, and temporal embedding consistency. Ablation studies assess the contribution of motif and temporal layers. The proposed model achieves strong performance across all metrics. On the AMiner dataset, identity coherence reaches 0.854, with a role classification accuracy of 80.2%. GAT demonstrates the highest temporal consistency and resilience to noise. Role trajectories and motif patterns confirm the emergence of stable and transient identities over time. The results validate the fact that the framework is not only associated with healthy quantitative performance but also offers information on behavioral development. The model will be expanded with semantic representations and be more concerned with ethical considerations, such as privacy, fairness, and transparency, to make identity modeling in artificial intelligence systems responsible and trustworthy. Full article
(This article belongs to the Special Issue Modeling and Data Analysis of Complex Networks)
Show Figures

Figure 1

26 pages, 2445 KB  
Article
Image-Based Deep Learning Approach for Drilling Kick Risk Prediction
by Wei Liu, Yuansen Wei, Jiasheng Fu, Qihao Li, Yi Zou, Tao Pan and Zhaopeng Zhu
Processes 2025, 13(10), 3251; https://doi.org/10.3390/pr13103251 - 13 Oct 2025
Viewed by 211
Abstract
As oil and gas exploration and development advance into deep and ultra-deep areas, kick accidents are becoming more frequent during drilling operations, posing a serious threat to construction safety. Traditional kick monitoring methods are limited in their multivariate coupling modeling. These models rely [...] Read more.
As oil and gas exploration and development advance into deep and ultra-deep areas, kick accidents are becoming more frequent during drilling operations, posing a serious threat to construction safety. Traditional kick monitoring methods are limited in their multivariate coupling modeling. These models rely too heavily on single-feature weights, making them prone to misjudgment. Therefore, this paper proposes a drilling kick risk prediction method based on image modality. First, a sliding window mechanism is used to slice key drilling parameters in time series to extract multivariate data for continuous time periods. Second, data processing is performed to construct joint logging curve image samples. Then, classical CNN models such as VGG16 and ResNet are used to train and classify image samples; finally, the performance of the model on a number of indicators is evaluated and compared with different CNN and temporal neural network models. Finally, the model’s performance is evaluated across multiple metrics and compared with CNN and time series neural network models of different structures. Experimental results show that the image-based VGG16 model outperforms typical convolutional neural network models such as AlexNet, ResNet, and EfficientNet in overall performance, and significantly outperforms LSTM and GRU time series models in classification accuracy and comprehensive discriminative power. Compared to LSTM, the recall rate increased by 23.8% and the precision increased by 5.8%, demonstrating that its convolutional structure possesses stronger perception and discriminative capabilities in extracting local spatiotemporal features and recognizing patterns, enabling more accurate identification of kick risks. Furthermore, the pre-trained VGG16 model achieved an 8.69% improvement in accuracy compared to the custom VGG16 model, fully demonstrating the effectiveness and generalization advantages of transfer learning in small-sample engineering problems and providing feasibility support for model deployment and engineering applications. Full article
(This article belongs to the Section Energy Systems)
Show Figures

Figure 1

24 pages, 6626 KB  
Article
Harnessing GPS Spatiotemporal Big Data to Enhance Visitor Experience and Sustainable Management of UNESCO Heritage Sites: A Case Study of Mount Huangshan, China
by Jianping Sun, Shi Chen, Yinlan Huang, Huifang Rong and Qiong Li
ISPRS Int. J. Geo-Inf. 2025, 14(10), 396; https://doi.org/10.3390/ijgi14100396 - 12 Oct 2025
Viewed by 331
Abstract
In the era of big data, the rapid proliferation of user-generated content enriched with geolocations offers new perspectives and datasets for probing the spatiotemporal dynamics of tourist mobility. Mining large-scale geospatial traces has become central to tourism geography: it reveals preferences for attractions [...] Read more.
In the era of big data, the rapid proliferation of user-generated content enriched with geolocations offers new perspectives and datasets for probing the spatiotemporal dynamics of tourist mobility. Mining large-scale geospatial traces has become central to tourism geography: it reveals preferences for attractions and routes to enable intelligent recommendation, enhance visitor experience, and advance smart tourism, while also informing spatial planning, crowd management, and sustainable destination development. Using Mount Huangshan—a UNESCO World Cultural and Natural Heritage site—as a case study, we integrate GPS trajectories and geo-tagged photographs from 2017–2023. We apply a Density-Field Hotspot Detector (DF-HD), a Space–Time Cube (STC), and spatial gridding to analyze behavior from temporal, spatial, and fully spatiotemporal perspectives. Results show a characteristic “double-peak, double-trough” seasonal pattern in the number of GPS tracks, cumulative track length, and geo-tagged photos. Tourist behavior exhibits pronounced elevation dependence, with clear vertical differentiation. DF-HD efficiently delineates hierarchical hotspot areas and visitor interest zones, providing actionable evidence for demand-responsive crowd diversion. By integrating sequential time slices with geography in a 3D framework, the STC exposes dynamic spatiotemporal associations and evolutionary regularities in visitor flows, supporting real-time crowd diagnosis and optimized spatial resource allocation. Comparative findings further confirm that Huangshan’s seasonal intensity is significantly lower than previously reported, while the high agreement between trajectory density and gridded photos clarifies the multi-tier clustering of route popularity. These insights furnish a scientific basis for designing secondary tour loops, alleviating pressure on core areas, and charting an effective pathway toward internal structural optimization and sustainable development of the Mount Huangshan Scenic Area. Full article
(This article belongs to the Special Issue Spatial Information for Improved Living Spaces)
Show Figures

Figure 1

12 pages, 1926 KB  
Article
Tracking False Lumen Remodeling with AI: A Variational Autoencoder Approach After Frozen Elephant Trunk Surgery
by Anja Osswald, Sharaf-Eldin Shehada, Matthias Thielmann, Alan B. Lumsden, Payam Akhyari and Christof Karmonik
J. Pers. Med. 2025, 15(10), 486; https://doi.org/10.3390/jpm15100486 - 11 Oct 2025
Viewed by 184
Abstract
Objective: False lumen (FL) thrombosis plays a key role in aortic remodeling after Frozen Elephant Trunk (FET) surgery, yet current imaging assessments are limited to categorical classifications. This study aimed to evaluate an unsupervised artificial intelligence (AI) algorithm based on a variational autoencoder [...] Read more.
Objective: False lumen (FL) thrombosis plays a key role in aortic remodeling after Frozen Elephant Trunk (FET) surgery, yet current imaging assessments are limited to categorical classifications. This study aimed to evaluate an unsupervised artificial intelligence (AI) algorithm based on a variational autoencoder (VAE) for automated, continuous quantification of FL thrombosis using serial computed tomography angiography (CTA). Methods: In this retrospective study, a VAE model was applied to axial CTA slices from 30 patients with aortic dissection who underwent FET surgery. The model encoded each image into a structured latent space, from which a continuous “thrombus score” was developed and derived to quantify the extent of FL thrombosis. Thrombus scores were compared between postoperative and follow-up scans to assess individual remodeling trajectories. Results: The VAE successfully encoded anatomical features of the false lumen into a structured latent space, enabling unsupervised classification of thrombus states. A continuous thrombus score was derived from this space, allowing slice-by-slice quantification of thrombus burden across the aorta. The algorithm demonstrated robust reconstruction accuracy and consistent separation of fully patent, partially thrombosed, and completely thrombosed lumen states without the need for manual annotation. Across the cohort, 50% of patients demonstrated an increase in thrombus score over time, 40% a decrease, and 10% remained unchanged. Despite these individual differences, no statistically significant change in overall thrombus burden was observed at the group level (p = 0.82), emphasizing the importance of individualized longitudinal assessment. Conclusions: The VAE-based method enables reproducible, annotation-free quantification of FL thrombosis and captures patient-specific remodeling patterns. This approach may enhance post-FET surveillance and supports the integration of AI-driven tools into personalized aortic imaging workflows. Full article
Show Figures

Figure 1

20 pages, 4674 KB  
Article
Gate-iInformer: Enhancing Long-Sequence Fuel Forecasting in Aviation via Inverted Transformers and Gating Networks
by Yanxiong Wu, Junqi Fu, Yu Li, Wenjing Feng, Yongshuo Zhu and Lu Li
Aerospace 2025, 12(10), 904; https://doi.org/10.3390/aerospace12100904 - 9 Oct 2025
Viewed by 236
Abstract
Accurately predicting aircraft fuel consumption is vital for aviation safety, operational efficiency, and resource optimization, yet existing models face key limitations. Traditional physical models rely on prior assumptions, while mainstream deep learning models use fixed architectures and time-slice tokens—failing to adapt to distinct [...] Read more.
Accurately predicting aircraft fuel consumption is vital for aviation safety, operational efficiency, and resource optimization, yet existing models face key limitations. Traditional physical models rely on prior assumptions, while mainstream deep learning models use fixed architectures and time-slice tokens—failing to adapt to distinct flight phases and losing long-range temporal features critical for cross-phase dependency capture. This paper proposes Gate-iInformer, an adaptive framework centered on iInformer with a gating network. It treats flight parameters as independent tokens, integrates Informer to handle long-range dependencies, and uses the gating network to dynamically select pre-trained phase-specific sub-models. Validated on 21,000 Air China 2023 medium-aircraft flights, it reduces MAE and RMSE by up to 53.38% and 44.51%, achieves 0.068 MAE in landing, and outperforms benchmarks. Its prediction latency is under 0.5 s, meeting ADS-B needs. Future work will expand data sources to enhance generalization, boosting aviation intelligent operation. Full article
(This article belongs to the Section Air Traffic and Transportation)
Show Figures

Figure 1

20 pages, 1853 KB  
Article
Enhanced U-Net for Spleen Segmentation in CT Scans: Integrating Multi-Slice Context and Grad-CAM Interpretability
by Sowad Rahman, Md Azad Hossain Raju, Abdullah Evna Jafar, Muslima Akter, Israt Jahan Suma and Jia Uddin
BioMedInformatics 2025, 5(4), 56; https://doi.org/10.3390/biomedinformatics5040056 - 8 Oct 2025
Viewed by 380
Abstract
Accurate spleen segmentation in abdominal CT scans remains a critical challenge in medical image analysis due to variable morphology, low tissue contrast, and proximity to similar anatomical structures. This paper presents an enhanced U-Net architecture that addresses these challenges through multi-slice contextual integration [...] Read more.
Accurate spleen segmentation in abdominal CT scans remains a critical challenge in medical image analysis due to variable morphology, low tissue contrast, and proximity to similar anatomical structures. This paper presents an enhanced U-Net architecture that addresses these challenges through multi-slice contextual integration and interpretable deep learning. Our approach incorporates three-channel inputs from adjacent CT slices, implements a hybrid loss function combining Dice and binary cross-entropy terms, and integrates Grad-CAM visualization for enhanced model interpretability. Comprehensive evaluation on the Medical Decathlon dataset demonstrates superior performance, with a Dice similarity coefficient of 0.923 ± 0.04, outperforming standard 2D approaches by 3.2%. The model exhibits robust performance across varying slice thicknesses, contrast phases, and pathological conditions. Grad-CAM analysis reveals focused attention on spleen–tissue interfaces and internal vascular structures, providing clinical insight into model decision-making. The system demonstrates practical applicability for automated splenic volumetry, trauma assessment, and surgical planning, with processing times suitable for clinical workflow integration. Full article
Show Figures

Figure 1

32 pages, 3888 KB  
Review
AI-Driven Innovations in 3D Printing: Optimization, Automation, and Intelligent Control
by Fatih Altun, Abdulcelil Bayar, Abdulhammed K. Hamzat, Ramazan Asmatulu, Zaara Ali and Eylem Asmatulu
J. Manuf. Mater. Process. 2025, 9(10), 329; https://doi.org/10.3390/jmmp9100329 - 7 Oct 2025
Viewed by 966
Abstract
By greatly increasing automation, accuracy, and flexibility at every step of the additive manufacturing process, from design and production to quality assurance, artificial intelligence (AI) is revolutionizing the 3D printing industry. The integration of AI algorithms into 3D printing systems enables real-time optimization [...] Read more.
By greatly increasing automation, accuracy, and flexibility at every step of the additive manufacturing process, from design and production to quality assurance, artificial intelligence (AI) is revolutionizing the 3D printing industry. The integration of AI algorithms into 3D printing systems enables real-time optimization of print parameters, accurate prediction of material behavior, and early defect detection using computer vision and sensor data. Machine learning (ML) techniques further streamline the design-to-production pipeline by generating complex geometries, automating slicing processes, and enabling adaptive, self-correcting control during printing—functions that align directly with the principles of Industry 4.0/5.0, where cyber-physical integration, autonomous decision-making, and human–machine collaboration drive intelligent manufacturing systems. Along with improving operational effectiveness and product uniformity, this potent combination of AI and 3D printing also propels the creation of intelligent manufacturing systems that are capable of self-learning. This confluence has the potential to completely transform sectors including consumer products, healthcare, construction, and aerospace as it develops. This comprehensive review explores how AI enhances the capabilities of 3D printing, with a focus on process optimization, defect detection, and intelligent control mechanisms. Moreover, unresolved challenges are highlighted—including data scarcity, limited generalizability across printers and materials, certification barriers in safety-critical domains, computational costs, and the need for explainable AI. Full article
Show Figures

Figure 1

21 pages, 4285 KB  
Article
Spatiotemporal Modeling and Intelligent Recognition of Sow Estrus Behavior for Precision Livestock Farming
by Kaidong Lei, Bugao Li, Hua Yang, Hao Wang, Di Wang and Benhai Xiong
Animals 2025, 15(19), 2868; https://doi.org/10.3390/ani15192868 - 30 Sep 2025
Viewed by 248
Abstract
Accurate recognition of estrus behavior in sows is of great importance for achieving scientific breeding management, improving reproductive efficiency, and reducing labor costs in modern pig farms. However, due to the evident spatiotemporal continuity, stage-specific changes, and ambiguous category boundaries of estrus behaviors, [...] Read more.
Accurate recognition of estrus behavior in sows is of great importance for achieving scientific breeding management, improving reproductive efficiency, and reducing labor costs in modern pig farms. However, due to the evident spatiotemporal continuity, stage-specific changes, and ambiguous category boundaries of estrus behaviors, traditional methods based on static images or manual observation suffer from low efficiency and high misjudgment rates in practical applications. To address these issues, this study follows a video-based behavior recognition approach and designs three deep learning model structures: (Convolutional Neural Network combined with Long Short-Term Memory) CNN + LSTM, (Three-Dimensional Convolutional Neural Network) 3D-CNN, and (Convolutional Neural Network combined with Temporal Convolutional Network) CNN + TCN, aiming to achieve high-precision recognition and classification of four key behaviors (SOB, SOC, SOS, SOW) during the estrus process in sows. In terms of data processing, a sliding window strategy was adopted to slice the annotated video sequences, constructing image sequence samples with uniform length. The training, validation, and test sets were divided in a 6:2:2 ratio, ensuring balanced distribution of behavior categories. During model training and evaluation, a systematic comparative analysis was conducted from multiple aspects, including loss function variation (Loss), accuracy, precision, recall, F1-score, confusion matrix, and ROC-AUC curves. Experimental results show that the CNN + TCN model performed best overall, with validation accuracy exceeding 0.98, F1-score approaching 1.0, and an average AUC value of 0.9988, demonstrating excellent recognition accuracy and generalization ability. The 3D-CNN model performed well in recognizing short-term dynamic behaviors (such as SOC), achieving a validation F1-score of 0.91 and an AUC of 0.770, making it suitable for high-frequency, short-duration behavior recognition. The CNN + LSTM model exhibited good robustness in handling long-duration static behaviors (such as SOB and SOS), with a validation accuracy of 0.99 and an AUC of 0.9965. In addition, this study further developed an intelligent recognition system with front-end visualization, result feedback, and user interaction functions, enabling local deployment and real-time application of the model in farming environments, thus providing practical technical support for the digitalization and intelligentization of reproductive management in large-scale pig farms. Full article
Show Figures

Figure 1

18 pages, 1985 KB  
Article
AI-Enhanced Deep Learning Framework for Pulmonary Embolism Detection in CT Angiography
by Nan-Han Lu, Chi-Yuan Wang, Kuo-Ying Liu, Yung-Hui Huang and Tai-Been Chen
Bioengineering 2025, 12(10), 1055; https://doi.org/10.3390/bioengineering12101055 - 29 Sep 2025
Viewed by 381
Abstract
Pulmonary embolism (PE) on CT pulmonary angiography (CTPA) demands rapid, accurate assessment, yet small, low-contrast clots in distal arteries remain challenging. We benchmarked ten fully convolutional network (FCN) backbones and introduced Consensus Intersection-Optimized Fusion (CIOF)—a K-of-M, pixel-wise mask fusion with the voting threshold [...] Read more.
Pulmonary embolism (PE) on CT pulmonary angiography (CTPA) demands rapid, accurate assessment, yet small, low-contrast clots in distal arteries remain challenging. We benchmarked ten fully convolutional network (FCN) backbones and introduced Consensus Intersection-Optimized Fusion (CIOF)—a K-of-M, pixel-wise mask fusion with the voting threshold K* selected on training patients to maximize IoU. Using the FUMPE cohort (35 patients; 12,034 slices) with patient-based random splits (18 train, 17 test), we trained five FCN architectures (each with Adam and SGDM) and evaluated segmentation with IoU, Dice, FNR/FPR, and latency. CIOF achieved the best overall performance (mean IoU 0.569; mean Dice 0.691; FNR 0.262), albeit with a higher runtime (~63.7 s per case) because all ten models are executed and fused; the strongest single backbone was Inception-ResNetV2 + SGDM (IoU 0.530; Dice 0.648). Stratified by embolization ratio, CIOF remained superior across <10−4, 10−4–10−3, and >10−3 clot burdens, with mean IoU/Dice = 0.238/0.328, 0.566/0.698, and 0.739/0.846, respectively—demonstrating gains for tiny, subsegmental emboli. These results position CIOF as an accuracy-oriented, interpretable ensemble for offline or second-reader use, while faster single backbones remain candidates for time-critical triage. Full article
(This article belongs to the Section Biosignal Processing)
Show Figures

Figure 1

28 pages, 1463 KB  
Article
Strategic Management Knowledge Map via BERTopic (1980–2025): Evolution, Integration, and Application
by Kuei-Kuei Lai, Chih-Wen Hsiao and Yu-Jin Hsu
Appl. Syst. Innov. 2025, 8(5), 142; https://doi.org/10.3390/asi8050142 - 29 Sep 2025
Viewed by 490
Abstract
Problem: Amid digital disruption and the cross-fertilization of RBV, DCV, and KBV, strategic management knowledge has grown fragmented with blurred boundaries. Conventional mapping (citation/co-word, LDA) lacks semantic and temporal resolution, obscuring overlaps, divergences, and turning points and hindering links to actionable indicators (e.g., [...] Read more.
Problem: Amid digital disruption and the cross-fertilization of RBV, DCV, and KBV, strategic management knowledge has grown fragmented with blurred boundaries. Conventional mapping (citation/co-word, LDA) lacks semantic and temporal resolution, obscuring overlaps, divergences, and turning points and hindering links to actionable indicators (e.g., the Balanced Scorecard). Hence, an integrated, semantically faithful, time-stamped map is needed to bridge research and operational metrics. Gap: Prior maps rely on citation/co-word signals, miss textual meaning, and treat RBV/DCV/KBV in isolation—lacking a theory-aligned, time-stamped, manager-oriented synthesis. Objectives: This study aims to (1) reveal how RBV, DCV, and KBV evolve and interrelate over time; (2) produce an integrated, semantically grounded map; and (3) translate selected themes into actionable managerial indicators. Method: We analyzed 25,907 WoS articles (1980–2025) with BERTopic (Sentence-BERT + UMAP + HDBSCAN + c-TF-IDF). We used an RBV/DCV/KBV lexicon to guide retrieval/interpretation (not to constrain modeling). We discovered 230 topics, retained 33 via coherence (C_V), and benchmarked them against LDA. Key findings: A concise set of 33 high-quality themes with a higher C_V than LDA on this corpus was established. A Fish-Scale view (overlapping subfields across economics, management, sociology) that clarifies RBV–DCV–KBV intersections was achieved. Era-sliced prevalence shows how themes emerge and recombine over 1980–2025. Selected themes mapped to Balanced Scorecard (BSC) indicators linking capabilities → processes → customer outcomes → financial results. Contribution: A clear, time-aware synthesis of RBV–DCV–KBV and a scalable, reproducible pipeline for structuring fragmented theory landscapes are presented in this study—bridging scholarly integration with managerial application via BSC mapping. Full article
(This article belongs to the Topic Social Sciences and Intelligence Management, 2nd Volume)
Show Figures

Figure 1

19 pages, 5648 KB  
Article
Role of RET-Regulated GDNF-GFRα1 Endocytosis in Methamphetamine-Induced Neurotoxicity
by Mengran Lv, Baoyu Shen, Zhenling Wu, Genmeng Yang, Yuanyuan Cao, Yuan Zhang, Junjie Shu, Wenjuan Dong, Zhenping Hou, Di Jing, Xinjie Zhang, Yuhan Hou, Jing Xu, Lihua Li and Shijun Hong
Int. J. Mol. Sci. 2025, 26(19), 9522; https://doi.org/10.3390/ijms26199522 - 29 Sep 2025
Viewed by 295
Abstract
Methamphetamine (METH) is a highly addictive synthetic psychostimulant that can induce severe neurotoxicity, leading to neurodegeneration similar to neurodegenerative diseases. The endocytosis of glial cell line-derived neurotrophic factor (GDNF) and its family receptor alpha 1 (GFRα1), regulated by transmembrane receptor tyrosine kinase (RET), [...] Read more.
Methamphetamine (METH) is a highly addictive synthetic psychostimulant that can induce severe neurotoxicity, leading to neurodegeneration similar to neurodegenerative diseases. The endocytosis of glial cell line-derived neurotrophic factor (GDNF) and its family receptor alpha 1 (GFRα1), regulated by transmembrane receptor tyrosine kinase (RET), has been shown to resist neurodegeneration. Specifically, the endocytosis of GDNF-GFRα1 mediated by RET is crucial in protecting neurons. Although many molecular mechanisms of METH induced neurotoxicity have been explored, the obstacles to the neuroprotective effect of GDNF in the context of METH induced neurotoxicity are still unclear. In this study, an increase in cell apoptosis and GDNF expression was observed in the hippocampus of METH abusers. METH also induces cell degeneration, cytotoxicity, and GDNF expression and release in hippocampal neuronal (HT-22) cells in a concentration-dependent manner (0.25, 0.5, 1, 2, and 4 mM) and time-dependent manner (3, 6, 12, 24, and 48 h). Meanwhile, after 24 h of exposure to METH (2mM), apoptosis, impaired endocytosis of GDNF-GFRα1, and decreased expression of RET were observed in HT-22 cells and organotypic hippocampal slices of mice. More notably, overexpression of RET weakened METH induced cell degeneration, apoptosis, and disruption of GDNF-GFRα1 endocytosis in HT-22 cells. This study suggests that RET is a key molecule for METH to disrupt GDNF-mediated neuroprotective signaling, and targeting RET-mediated endocytosis of GDNF-GFRα1 may be a potential therapeutic approach for METH induced neurotoxicity and neurodegeneration. Full article
(This article belongs to the Section Molecular Toxicology)
Show Figures

Figure 1

15 pages, 2039 KB  
Article
Optimising Multimodal Image Registration Techniques: A Comprehensive Study of Non-Rigid and Affine Methods for PET/CT Integration
by Babar Ali, Mansour M. Alqahtani, Essam M. Alkhybari, Ali H. D. Alshehri, Mohammad Sayed and Tamoor Ali
Diagnostics 2025, 15(19), 2484; https://doi.org/10.3390/diagnostics15192484 - 28 Sep 2025
Viewed by 458
Abstract
Background/Objective: Multimodal image registration plays a critical role in modern medical imaging, enabling the integration of complementary modalities such as positron emission tomography (PET) and computed tomography (CT). This study compares the performance of three widely used image registration techniques—Demons Image Registration [...] Read more.
Background/Objective: Multimodal image registration plays a critical role in modern medical imaging, enabling the integration of complementary modalities such as positron emission tomography (PET) and computed tomography (CT). This study compares the performance of three widely used image registration techniques—Demons Image Registration with Modality Transformation, Free-Form Deformation using the Medical Image Registration Toolbox (MIRT), and MATLAB Intensity-Based Registration—in terms of improving PET/CT image alignment. Methods: A total of 100 matched PET/CT image slices from a clinical scanner were analysed. Preprocessing techniques, including histogram equalisation and contrast enhancement (via imadjust and adapthisteq), were applied to minimise intensity discrepancies. Each registration method was evaluated under varying parameter conditions with regard to sigma fluid (range 4–8), histogram bins (100 to 256), and interpolation methods (linear and cubic). Performance was assessed using quantitative metrics: root mean square error (RMSE), mean squared error (MSE), mean absolute error (MAE), the Pearson correlation coefficient (PCC), and standard deviation (STD). Results: Demons registration achieved optimal performance at a sigma fluid value of 6, with an RMSE of 0.1529, and demonstrated superior computational efficiency. The MIRT showed better adaptability to complex anatomical deformations, with an RMSE of 0.1725. MATLAB Intensity-Based Registration, when combined with contrast enhancement, yielded the highest accuracy (RMSE = 0.1317 at alpha = 6). Preprocessing improved registration accuracy, reducing the RMSE by up to 16%. Conclusions: Each registration technique has distinct advantages: the Demons algorithm is ideal for time-sensitive tasks, the MIRT is suited to precision-driven applications, and MATLAB-based methods offer flexible processing for large datasets. This study provides a foundational framework for optimising PET/CT image registration in both research and clinical environments. Full article
(This article belongs to the Special Issue Diagnostics in Oncology Research)
Show Figures

Figure 1

18 pages, 3029 KB  
Article
Polarization and Depolarization Current Characteristics of Cables at Different Water Immersion Stages
by Yuyang Jiao, Jingjiang Qu, Yingqiang Shang, Jingyue Ma, Jiren Chen, Jun Xiong and Zepeng Lv
Energies 2025, 18(19), 5094; https://doi.org/10.3390/en18195094 - 25 Sep 2025
Viewed by 250
Abstract
To address the insulation degradation caused by moisture intrusion due to damage to the outer sheath of power cables, this study systematically analyzed the charge transport characteristics of XLPE cables at different water immersion stages using polarization/depolarization current (PDC) measurements. An evaluation method [...] Read more.
To address the insulation degradation caused by moisture intrusion due to damage to the outer sheath of power cables, this study systematically analyzed the charge transport characteristics of XLPE cables at different water immersion stages using polarization/depolarization current (PDC) measurements. An evaluation method for assessing water immersion levels was proposed based on conductivity, charge density, and charge mobility. Experiments were conducted on commercial 10 kV XLPE cable samples subjected to accelerated water immersion for durations ranging from 0 to 30 days. PDC data were collected via a custom-built three-electrode measurement platform. The results indicated that with increasing immersion time, the decay rate of polarization/depolarization currents slowed, the steady-state current amplitude rose significantly, and the DC conductivity increased from 1.86 × 10−17 S/m to 2.70 × 10−15 S/m—a nearly two-order-of-magnitude increase. The Pearson correlation coefficient between charge mobility and immersion time reached 0.96, indicating a strong positive correlation. Additional tests on XLPE insulation slices showed a rapid rise in conductivity during early immersion, a decrease in breakdown voltage from 93.64 kV to 66.70 kV, and enhanced space charge accumulation under prolonged immersion and higher electric fields. The proposed dual-parameter criterion (conductivity and charge mobility) effectively distinguishes between early and advanced stages of cable water immersion, offering a practical approach for non-destructive assessment of insulation conditions and early detection of moisture intrusion, with significant potential for application in predictive maintenance and insulation diagnostics. Full article
Show Figures

Figure 1

16 pages, 3974 KB  
Article
Optimizing FDM Printing Parameters via Orthogonal Experiments and Neural Networks for Enhanced Dimensional Accuracy and Efficiency
by Jinxing Wu, Yi Zhang, Wenhao Hu, Changcheng Wu, Zuode Yang and Guangyi Duan
Coatings 2025, 15(10), 1117; https://doi.org/10.3390/coatings15101117 - 24 Sep 2025
Viewed by 422
Abstract
Optimizing printing parameters is crucial for enhancing the efficiency, surface quality, and dimensional accuracy of Fused Deposition Modeling (FDM) processes. A review of numerous publications reveals that most scholars analyze factors such as nozzle diameter and printing speed, while few investigate the impact [...] Read more.
Optimizing printing parameters is crucial for enhancing the efficiency, surface quality, and dimensional accuracy of Fused Deposition Modeling (FDM) processes. A review of numerous publications reveals that most scholars analyze factors such as nozzle diameter and printing speed, while few investigate the impact of layer thickness, infill density, and shell layer count on print quality. Therefore, this study employed 3D slicing software to process the three-dimensional model and design printing process parameters. It systematically investigated the effects of layer thickness, infill density, and number of shells on printing time and geometric accuracy, quantifying the evaluation through volumetric error. Using an ABS connecting rod model, optimal parameters were determined within the defined range through orthogonal experimental design and signal-to-noise ratio (S/N) analysis. Subsequently, a backpropagation (BP) neural network was constructed to establish a predictive model for process optimization. Results indicate that parameter selection significantly impacts print duration and surface quality. Validation confirmed that the combination of 0.1 mm layer thickness, 40% infill density, and 5-layer shell configuration achieves the highest dimensional accuracy (minimum volumetric error and S/N value). Under this configuration, the volumetric error rate was 3.062%, with an S/N value of −9.719. Compared to other parameter combinations, this setup significantly reduced volumetric error, enhanced surface texture, and improved overall print precision. Statistical analysis indicates that the BP neural network model achieves a Mean Absolute Percentage Error (MAPE) of no more than 5.41% for volume error rate prediction and a MAPE of 5.58% for signal-to-noise ratio prediction. This validates the model’s high-precision predictive capability, with the established prediction model providing effective data support for FDM parameter optimization. Full article
Show Figures

Figure 1

6 pages, 872 KB  
Proceeding Paper
Temporary Dry Eyes Caused by Eating Fried Foods
by Yung-Fu Liu, Feng-Ming Yeh, Ya-Hui Hsieh, Cheng-Hung Lai, Wei-Hsin Chen and Der-Chin Chen
Eng. Proc. 2025, 103(1), 30; https://doi.org/10.3390/engproc2025103030 - 22 Sep 2025
Viewed by 264
Abstract
Tear osmotic pressure, tear volume, and quality were measured before and after subjects without dry eye syndrome ate fried chicken slices for one week. By analyzing the data, we explored the causes of temporary dry eye syndrome. A 2 mL volume of normal [...] Read more.
Tear osmotic pressure, tear volume, and quality were measured before and after subjects without dry eye syndrome ate fried chicken slices for one week. By analyzing the data, we explored the causes of temporary dry eye syndrome. A 2 mL volume of normal saline was added to fluorescent tear test paper, which was applied to the conjunctiva of the subject, and the tear breakup time and tear lake height were measured with a digital slit lamp. The tear test paper was placed on the outside of the subject’s lower eyelid to test their tear volume. A total of 29 subjects, aged between 20 and 55 years old, ate fried foods for one week. The amount of tears produced before and after they ate fried chicken slices was tested using paired samples t-tests. The tear volume in the left and right eyes decreased at a significance level of p < 0.05. The tear membrane breakup time before and after treatment was analyzed using fluorescent reagents and digital slit lamps. The paired-sample t-test results showed that there was a statistically significant difference (p < 0.05). Eating fried chicken slices for a week significantly contributed to dry eyes, regardless of gender and age. Full article
(This article belongs to the Proceedings of The 8th Eurasian Conference on Educational Innovation 2025)
Show Figures

Figure 1

Back to TopTop