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Search Results (677)

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Keywords = the effective stress principle

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17 pages, 2065 KB  
Article
A Damage Constitutive Model for Rock Considering Crack Propagation Under Uniaxial Compression
by Shengnan Li, Hao Yang, Yu Li, Xianglong Liu, Junhao Tan, Yuecheng Guo, Qiao Liang, Yaqian Shen, Xingxing Wei and Chenzhen Ma
Modelling 2025, 6(4), 116; https://doi.org/10.3390/modelling6040116 - 1 Oct 2025
Abstract
This study aims to accurately characterize the nonlinear stress–strain evolution of rocks under uniaxial compression considering crack propagation. First, the rock meso-structure was generalized into intact rock unit cells, crack propagation damage unit cells, and pore unit cells according to phenomenological theory. A [...] Read more.
This study aims to accurately characterize the nonlinear stress–strain evolution of rocks under uniaxial compression considering crack propagation. First, the rock meso-structure was generalized into intact rock unit cells, crack propagation damage unit cells, and pore unit cells according to phenomenological theory. A mesoscopic rock stress model considering crack propagation was established based on the static equilibrium relationship of the unit cells, and the effective stress of the crack propagation damage unit cells was solved based on fracture mechanics. Then, the geometric damage theory and conservation-of-energy principle were introduced to construct the damage evolution equation for rock crack propagation. On this basis, the effective stress of the damage unit cells and the crack propagation damage equation were incorporated into the rock meso-structure static equilibrium equation, and the effect of nonlinear deformation in the soft rock compaction stage was considered to establish a rock damage constitutive model based on mesoscopic crack propagation evolution. Finally, methods for determining model parameters were proposed, and the effects of the model parameters on rock stress–strain curves were explored. The results showed that the theoretical model calculations agreed well with the experimental results, thus verifying the rationality of the damage constitutive model and the clear physical meaning of the model parameters. Full article
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29 pages, 9747 KB  
Article
Analysis of Subsurface Damage Based on K9 Glass Grinding
by Yao Liu, Jingjing Xie, Ruiliang Li, Jiankun Gao, Ming Li and Lin Sun
Materials 2025, 18(19), 4558; https://doi.org/10.3390/ma18194558 - 30 Sep 2025
Abstract
During the grinding process of K9 glass, various forms of surface damage—such as indentations and pitting—as well as subsurface damage—including cracks and residual stress—are generated. This paper focuses on the planetary grinding method utilizing bonded abrasives for both process research and subsurface damage [...] Read more.
During the grinding process of K9 glass, various forms of surface damage—such as indentations and pitting—as well as subsurface damage—including cracks and residual stress—are generated. This paper focuses on the planetary grinding method utilizing bonded abrasives for both process research and subsurface damage detection. It examines the timeliness of grinding duration and analyzes the effects of abrasive grain size and grinding pressure on surface quality. Building upon the principle of differential etching, an improved HF chemical etching method is proposed to establish a relationship model that correlates the depth of subsurface damage with abrasive grain size, applied pressure, and surface roughness. Full article
(This article belongs to the Section Advanced and Functional Ceramics and Glasses)
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26 pages, 4070 KB  
Article
Evaluation of Paper Mill Sludge Using Bioindicators: Response of Soil Microorganisms and Plants
by Adam Pochyba, Dagmar Samešová, Juraj Poništ, Michal Sečkár, Jarmila Schmidtová, Marián Schwarz and Darina Veverková
Sustainability 2025, 17(19), 8788; https://doi.org/10.3390/su17198788 - 30 Sep 2025
Abstract
The growing demand for sustainable waste management practices has prompted interest in the land application of paper sludge as an alternative to landfilling and incineration. This study evaluates the environmental potential of paper sludge derived from recycled hygienic paper production by investigating its [...] Read more.
The growing demand for sustainable waste management practices has prompted interest in the land application of paper sludge as an alternative to landfilling and incineration. This study evaluates the environmental potential of paper sludge derived from recycled hygienic paper production by investigating its effects on soil respiration, seed germination, and seedling development. A comprehensive set of respirometric tests using the OxiTop® system assessed microbial activity in soil amended with various concentrations of paper sludge (1–100%). Concurrently, bioassays using Lepidium sativum L. and Pisum sativum L. seeds examined the phytotoxicity and physiological response during germination. The results show that low to moderate sludge concentrations (1–20%) stimulated microbial activity and enhanced germination parameters, with a germination index (GI) up to 150% at 1%. However, higher concentrations (>40%) led to oxygen depletion, microbial stress, and decreased plant growth, indicating potential phytotoxicity and the need for application thresholds. For certain intermediate concentrations (e.g., 30–40%), a delay of approximately 21 days before sowing is recommended to allow microbial communities to stabilize and avoid initial stress conditions for plants. This study demonstrates that controlled application of paper sludge in soil systems can serve as a viable and sustainable disposal method, supporting circular economy principles and reducing the environmental burden of paper industry by-products. Full article
(This article belongs to the Section Waste and Recycling)
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14 pages, 1767 KB  
Article
Enhancing Docosahexaenoic Acid Production by Schizochytrium sp. via Periodic Hydrogen Peroxide and p-Aminobenzoate Control
by Luqiang Jia, Mengyao Ma, Xingyue Wang, Ruoyu Wang and Shuqi Xin
Fermentation 2025, 11(10), 558; https://doi.org/10.3390/fermentation11100558 - 27 Sep 2025
Abstract
In producing docosahexaenoic acid (DHA) with Schizochytrium sp., the production yield of DHA can be effectively increased through using hydrogen peroxide (H2O2) and controlling its concentration at the desired level, since H2O2 is a common regulatory [...] Read more.
In producing docosahexaenoic acid (DHA) with Schizochytrium sp., the production yield of DHA can be effectively increased through using hydrogen peroxide (H2O2) and controlling its concentration at the desired level, since H2O2 is a common regulatory mediator for lipid accumulation in oleaginous microorganisms. However, when exposed to the environment of oxidative stress induced by the long-term exogenous addition of H2O2 over an extended time span, cells’ metabolic activity would be gradually decreased or even stopped, which ultimately results in a limited duration for producing DHA efficiently. In fact, the severe accumulation of ROS cannot be avoided when implementing the normal DHA fermentation batch without the use of exogenous H2O2 because of the necessity of supplying a mass of oxygen for cell respiration. Aiming to overcome these issues, a novel periodic feeding strategy for H2O2 and p-aminobenzoate was proposed, and the underlying principle of this strategy is that the substantial harm inflicted on cells due to their continuous exposure to the oxidative stress environment can be effectively alleviated through the implementation of a recovery treatment (p-aminobenzoate, reducing agent) subsequent to the environmental stimulus. When using this strategy, it was achieved that, concurrently, activities of the vital enzymes participating in lipid biosynthesis were maintained at their maximum levels and the maintenance coefficient of glucose reduced to its minimum level (0.0034 1/h vs. 0.0027 1/h) by controlling ROS concentration at lower and desired levels, and thus DHA concentration reached the maximum value of 1.49 ± 0.20 g/L, with a 49% increase compared to the control group. Full article
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11 pages, 1746 KB  
Article
DFT-Based Analysis on Structural, Electronic and Mechanical Properties of NiCoCr Medium-Entropy Alloy with C/N/O
by Shuqin Cheng, Yunfeng Luo, Yufan Yao, Yiren Wang and Fuhua Cao
Materials 2025, 18(19), 4494; https://doi.org/10.3390/ma18194494 - 26 Sep 2025
Abstract
This study employs first-principles calculations combined with the Special Quasirandom Structure (SQS) technique to investigate the impact of three interstitial elements C, N, and O, on the mechanical properties and stacking fault energy (SFE) of NiCoCr medium-entropy alloys. The results indicate that non-metallic [...] Read more.
This study employs first-principles calculations combined with the Special Quasirandom Structure (SQS) technique to investigate the impact of three interstitial elements C, N, and O, on the mechanical properties and stacking fault energy (SFE) of NiCoCr medium-entropy alloys. The results indicate that non-metallic O, C, and N tend to occupy octahedral interstitial sites, which can effectively release stress concentration and enhance the strength and deformability of the material. Differential charge density analysis shows that the dissolution of C, N, and O significantly alters the surrounding electronic environment, strengthening the interaction between solute atoms and metal atoms, thereby hindering dislocation glide and increasing the strength and hardness of the material. Elastic property analysis indicates that NiCoCr alloys doped with C, N, and O exhibit good ductility and anisotropic characteristics. Furthermore, the study of stacking fault energy reveals that the doping with C, N, and O can significantly increase the stacking fault energy of NiCoCr alloys, thereby optimizing their mechanical properties. These findings provide theoretical evidence for the design of advanced high-entropy alloys that combine high strength with good ductility. Full article
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42 pages, 1679 KB  
Review
Analysis of the Current Situation and Trends of Optical Sensing Technology Application for Facility Vegetable Life Information Detection
by Xiaodong Zhang, Zonghua Leng, Xinchen Wang, Shijie Tian, Yixue Zhang, Xiangyu Han and Zhaowei Li
Agronomy 2025, 15(9), 2229; https://doi.org/10.3390/agronomy15092229 - 21 Sep 2025
Viewed by 418
Abstract
The production of facility vegetables is of great significance but there are still limitations to this production in terms of yield and quality. Optical sensing technology offers a rapid and non-destructive solution for phenotypic analysis, which is superior to traditional destructive methods. This [...] Read more.
The production of facility vegetables is of great significance but there are still limitations to this production in terms of yield and quality. Optical sensing technology offers a rapid and non-destructive solution for phenotypic analysis, which is superior to traditional destructive methods. This article reviews and analyzes nine optical sensing technologies, including RGB imaging, and introduces the application of various algorithms in combination with detection principles throughout the entire growth cycle as well as key phenotypic characteristics of facility vegetables. Each technology has its advantages. For example, RGB and multi/high-spectrum technologies are the most frequently used while thermal imaging is particularly suitable for early detection of non-biological and biological stress responses, and these technologies can effectively obtain physiological, biochemical, yield, and quality information about crops. However, current research mainly focuses on laboratory verification and there is still a significant gap when it comes to practical production. Future progress will depend on the integration of multiple sensing technologies, data analysis based on artificial intelligence, and improvements in model interpretability. These developments will be crucial for ultimately achieving precise breeding and intelligent greenhouse management systems, and will gradually transition from basic phenotypic analysis to comprehensive decision support systems. Full article
(This article belongs to the Special Issue Crop Nutrition Diagnosis and Efficient Production)
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32 pages, 3156 KB  
Article
Magneto-Hygrothermal Deformation of FG Nanocomposite Annular Sandwich Nanoplates with Porous Core Using the DQM
by Fatemah H. H. Al Mukahal, Mohammed Sobhy and Aamna H. K. Al-Ali
Crystals 2025, 15(9), 827; https://doi.org/10.3390/cryst15090827 - 20 Sep 2025
Viewed by 230
Abstract
This study introduces a novel numerical approach to analyze the axisymmetric bending behavior of functionally graded (FG) graphene platelet (GPL)-reinforced annular sandwich nanoplates featuring a porous core. The nanostructures are exposed to coupled magnetic and hygrothermal environments. The porosity distribution and GPL weight [...] Read more.
This study introduces a novel numerical approach to analyze the axisymmetric bending behavior of functionally graded (FG) graphene platelet (GPL)-reinforced annular sandwich nanoplates featuring a porous core. The nanostructures are exposed to coupled magnetic and hygrothermal environments. The porosity distribution and GPL weight fraction are modeled as nonlinear functions through the thickness, capturing realistic gradation effects. The governing equations are derived using the virtual displacement principle, taking into account the Lorentz force and the interaction with an elastic foundation. To address the size-dependent behavior and thickness-stretching effects, the model employs the nonlocal strain gradient theory (NSGT) integrated with a modified version of Shimpi’s quasi-3D higher-order shear deformation theory (Q3HSDT). The differential quadrature method (DQM) is applied to obtain numerical solutions for the displacement and stress fields. A detailed parametric study is conducted to investigate the influence of various physical and geometric parameters, including the nonlocal parameter, strain gradient length scale, magnetic field strength, thermal effects, foundation stiffness, core thickness, and radius-to-thickness ratio. The findings support the development of smart, lightweight, and thermally adaptive nano-electromechanical systems (NEMS) and provide valuable insights into the mechanical performance of FG-GPL sandwich nanoplates. These findings have potential applications in transducers, nanosensors, and stealth technologies designed for ultrasound and radar detection. Full article
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15 pages, 2036 KB  
Article
Effect of Degradation During Multiple Primary Mechanical Recycling Processes on the Physical Properties and Biodegradation of Commercial PLA-Based Water Bottles
by Cristina Muñoz-Shugulí, Diana Morán, Eliezer Velásquez, José Manuel López-Vilariño and Carol López-de-Dicastillo
Polymers 2025, 17(18), 2542; https://doi.org/10.3390/polym17182542 - 20 Sep 2025
Viewed by 298
Abstract
For sustainable development aligned with circular economy principles, the recycling of biopolymers such as polylactic acid (PLA) is of growing interest. In this study, the effect of primary recycling through repeated mechanical reprocessing was investigated. PLA water bottle preforms were subjected to six [...] Read more.
For sustainable development aligned with circular economy principles, the recycling of biopolymers such as polylactic acid (PLA) is of growing interest. In this study, the effect of primary recycling through repeated mechanical reprocessing was investigated. PLA water bottle preforms were subjected to six consecutive extrusion cycles, and changes in its molecular structure and physical properties were evaluated. Structural analysis revealed a progressive degradation, evidenced by a great reduction in the molar mass and increase in the melt flow index, attributed both to the chain scission derived from the thermal degradation and shear stresses of the extrusion process, and hydrolysis at the ester linkage of the polymer. Recycled samples exhibited a darkening of the color and a continuous decrease in thermal stability. After six reprocessing cycles, PLA crystallinity increased from 6.9 to 39.5%, the cold crystallization process disappeared, and molecular weight reduced by up to 40%. Barrier properties were highly affected after reprocessing and by the increase in relative humidity. Biodegradation tests revealed that crystallinity affected considerably the biodegradation rate of PLA. Although the molecular weight was considerably reduced during reprocessing, the biodegradation was slowed down. These findings provide insights into the limitations and potential of mechanically recycled PLA for future material applications. Full article
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26 pages, 6893 KB  
Article
Angle-of-Attack, Induced Attitude Evolution in a Coupled Crater, and Plugging Penetration of Thin Concrete Targets
by Zheng Tao, Wenbin Li, Wei Zhu, Junjie Xu and Jihua Yan
Symmetry 2025, 17(9), 1572; https://doi.org/10.3390/sym17091572 - 19 Sep 2025
Viewed by 138
Abstract
To address the limitations of existing models that typically treat crater formation and shear plugging as independent processes and only consider angle of attack effects during the initial crater phase, this study proposes a dynamic shear _plugging model for projectile penetration into thin [...] Read more.
To address the limitations of existing models that typically treat crater formation and shear plugging as independent processes and only consider angle of attack effects during the initial crater phase, this study proposes a dynamic shear _plugging model for projectile penetration into thin concrete targets. The model is built upon the improved three-stage penetration theory and cavity expansion principles, and introduces a coupled cratering, plugging mechanism that captures the simultaneous interaction between these stages. A differential surface force approach is employed to describe the asymmetric stress distribution on the projectile nose under non-zero angle of attack conditions, while free surface effects are incorporated to refine local stress predictions. A series of validation experiments was performed with 30 mm rigid projectiles penetrating 27 MPa concrete slabs under different impact velocities and initial angles of attack. The results show that the proposed model achieves prediction errors of less than 20% for both residual velocity and exit attitude angle, significantly outperforming classical models such as those of Duan and Liu, which tend to underestimate post-impact deflection by treating cratering and plugging separately. Based on this validated framework, parametric studies were conducted to examine the effects of the initial inclination, impact velocity, and target thickness on the evolution of projectile attitude and angle of attack. The findings demonstrate that the dynamic shear plugging mechanism exerts a critical regulatory influence on projectile deflection during thin target penetration. This work, therefore, not only resolves the directional reversal issue inherent in earlier theories but also provides theoretical support for the engineering design of concrete protective structures subjected to angular impact conditions. Full article
(This article belongs to the Special Issue Symmetry, Asymmetry and Nonlinearity in Geomechanics)
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25 pages, 4535 KB  
Article
Numerical Simulation of an Icebreaker Ramming the Ice Ridge
by Wenbo Dong, Jiaming Chen, Yufei Zhang, Shisong Wei, Guangwei He and Fang Li
J. Mar. Sci. Eng. 2025, 13(9), 1815; https://doi.org/10.3390/jmse13091815 - 19 Sep 2025
Viewed by 199
Abstract
During polar navigation, icebreakers frequently encounter ice ridges, which can significantly reduce navigation efficiency and even pose threats to structural safety. Therefore, studying the ramming of ice ridges by the icebreaker is of great importance. In this study, the ice ridge is decoupled [...] Read more.
During polar navigation, icebreakers frequently encounter ice ridges, which can significantly reduce navigation efficiency and even pose threats to structural safety. Therefore, studying the ramming of ice ridges by the icebreaker is of great importance. In this study, the ice ridge is decoupled into the consolidated layer and the keel for modeling. The consolidated layer is simplified as layered ice, and an innovative hybrid empirical–numerical method is used to determine the icebreaking loads. For the keel, a failure model is developed using the Mohr–Coulomb criterion in combination with the effective stress principle, accounting for shear failure in porous media and incorporating both cohesion and internal friction angle. The ship is restricted to surge motion only. A comparative analysis with the model test results was conducted to assess the accuracy of the method, with the predicted ice resistance showing deviation of 9.85% in the consolidated ice area and 10.48% in the keel area. Ablation studies were conducted to investigate the effects of different ice ridge shapes, varying retreat distances, and different ship drafts on the performance of ramming the ice ridge. The proposed method can quickly and accurately calculate ice ridge loads and predict their motion responses, providing a suitable tool for on-site rapid navigability assessment and for the design of icebreakers. Full article
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12 pages, 3489 KB  
Article
Low-Voltage Stressed Inductive WPT System with Pull–Push Class EF2 Inverter
by Yuting Wang, Jiayue Kuang, Chang Li, Zhidi Chen, Jie Mei, Peng Chen and Jianghua Lu
Electronics 2025, 14(18), 3693; https://doi.org/10.3390/electronics14183693 - 18 Sep 2025
Viewed by 174
Abstract
A class E inverter has presented wide application prospects in inductive wireless power transfer (WPT) systems due to its significant advantages such as high operation frequency, high power density, and low cost. However, its semiconductor power device is subjected to voltage stress several [...] Read more.
A class E inverter has presented wide application prospects in inductive wireless power transfer (WPT) systems due to its significant advantages such as high operation frequency, high power density, and low cost. However, its semiconductor power device is subjected to voltage stress several times higher than the input DC voltage, which inevitably increases the risk of overvoltage failure and limits the system power level. In this manuscript, an inductive WPT system with the pull–push class EF2 inverter is proposed to significantly decrease the voltage stress and ensure soft switching characteristic. The working principle and time-domain waveforms of the pull–push class EF2 inverter are analyzed. Moreover, the differential equations and mathematical model of the resonant parameters are investigated. Compared with the conventional class E inverter, the output power of the proposed inductive WPT system is doubled under the same input voltage. A 100 W system prototype is designed at the operating frequency of 6.78 MHz (according to the A4WP standard) and its experimental results demonstrate the effectiveness and feasibility of the analysis. Full article
(This article belongs to the Special Issue Wireless Power Transfer Systems and Applications)
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23 pages, 7438 KB  
Article
Numerical Simulation on Multi-Fractures Propagation Behavior Based on Hybrid Finite-Discrete Method in Deep Shale Formation
by Bin Wang, Jingfeng Dong, Peiyao Zhou and Kaixin Liu
Processes 2025, 13(9), 2944; https://doi.org/10.3390/pr13092944 - 15 Sep 2025
Viewed by 228
Abstract
Hydraulic fracturing technology serves as the primary method for efficiently developing deep shale resources. During hydraulic fracturing, the thermal stress caused by the injection of fracturing fluid, which has low temperature, has a significant effect on the propagation of multiple hydraulic fractures in [...] Read more.
Hydraulic fracturing technology serves as the primary method for efficiently developing deep shale resources. During hydraulic fracturing, the thermal stress caused by the injection of fracturing fluid, which has low temperature, has a significant effect on the propagation of multiple hydraulic fractures in deep shale reservoirs. Due to the unclear mechanisms governing multi-fracture propagation in deep shale reservoirs, this study proposed a hydraulic fracturing model for multi-fracture propagation based on the principles of linear elastic fracture mechanics. The model was employed to investigate how formation properties and operational parameters influenced the expansion of multiple hydraulic fractures. The findings revealed that thermal stress fracturing caused by low-temperature fluid injection significantly affected the rock breakdown pressure and fracture initiation timing. Specifically, when the reservoir temperature exceeded 180 °C, the breakdown pressure decreased substantially, and the fracture initiation occurred much earlier. Moreover, an increase in rock thermal conductivity further reduced both the breakdown pressure and the propagation pressure, alleviating the “stress shadow” effect on intermediate fractures and promoting more uniform fracture growth. Furthermore, when the reservoir temperature surpassed 180 °C and the thermal conductivity exceeded 1.3 W/(m K), the influence of horizontal stress difference and cluster spacing on multi-fracture propagation diminished sharply—by more than 40%. This condition facilitated tight containment of the deep shale reservoir and significantly expanded the stimulated reservoir volume. These findings not only enriched and refined the theoretical understanding of hydraulic fracturing in deep shale reservoirs but also provided a valuable reference for optimizing fracturing parameters in the development of deep oil and gas reservoirs. Full article
(This article belongs to the Special Issue Advanced Technology in Unconventional Resource Development)
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15 pages, 1068 KB  
Article
Reducing Oil Waste Through Condition-Based Maintenance: A Diagnostic Study Using FTIR and Viscosity Monitoring
by Artur Wolak and Wojciech Krasodomski
Sustainability 2025, 17(18), 8214; https://doi.org/10.3390/su17188214 - 12 Sep 2025
Viewed by 287
Abstract
Engine oil condition critically affects vehicle performance, fuel efficiency, and engine durability. While conventional oil change strategies are based on fixed intervals or mileage thresholds, they often neglect real operating conditions and the actual state of lubricant degradation. This study investigates nine used [...] Read more.
Engine oil condition critically affects vehicle performance, fuel efficiency, and engine durability. While conventional oil change strategies are based on fixed intervals or mileage thresholds, they often neglect real operating conditions and the actual state of lubricant degradation. This study investigates nine used engine oil samples collected from passenger vehicles operating in diverse environments, including city traffic, highway routes, hybrid systems, and diesel engines. The oils were assessed using kinematic viscosity measurements and Fourier transform infrared (FTIR) spectroscopy to monitor key degradation indicators—oxidation, nitration, sulfonation, fuel dilution, soot contamination, and additive depletion. Each case is fully documented with detailed operational histories, facilitating a nuanced, real-world understanding of oil aging. The results demonstrate that degradation levels vary considerably, even under similar mileage ranges, highlighting the influence of urban usage patterns and engine design. In several cases, premature or delayed oil changes were observed, confirming that standard service intervals may be suboptimal. FTIR proved effective in detecting subtle chemical transformations, particularly in samples affected by biofuel components or prolonged thermal stress. These findings emphasize the value of integrating laboratory diagnostics into oil change decision-making and support more tailored maintenance strategies. Such an approach can reduce unnecessary oil replacement, limit waste generation, and extend engine lifespan, contributing to both environmental and economic sustainability. This study supports the implementation of condition-based oil change strategies to minimize lubricant waste and promote maintenance practices aligned with sustainability principles. Full article
(This article belongs to the Section Energy Sustainability)
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16 pages, 2410 KB  
Article
Constitutive Model Based on Stress Relaxation for Composite Modified Double-Base Propellants and Master Curve of Relaxation Modulus
by Yao Li, Jinsheng Xu, Changsheng Zhou, Xiong Chen and Xiumin Yang
Aerospace 2025, 12(9), 817; https://doi.org/10.3390/aerospace12090817 - 10 Sep 2025
Viewed by 289
Abstract
This study investigates the constitutive model and relaxation modulus master curve of composite modified double-base (CMDB) propellants through uniaxial constant-rate tensile tests and stress relaxation tests. The experimental observations demonstrate that CMDB propellants exhibit pronounced strain-rate dependence and temperature dependence. Specifically, the yield [...] Read more.
This study investigates the constitutive model and relaxation modulus master curve of composite modified double-base (CMDB) propellants through uniaxial constant-rate tensile tests and stress relaxation tests. The experimental observations demonstrate that CMDB propellants exhibit pronounced strain-rate dependence and temperature dependence. Specifically, the yield stress and fracture strength of the propellant increase with increasing strain rate and decrease with increasing temperature. Conversely, the fracture strain increases with increasing temperature. The stress–strain curves of CMDB propellants display marked nonlinearity, attributed to progressive damage accumulation. The relaxation modulus increases significantly with decreasing temperature. Utilizing the time-temperature superposition principle, we constructed a master curve model for the relaxation modulus of CMDB propellants across varying temperatures. Furthermore, based on the observed stress relaxation behavior, a nonlinear constitutive model for CMDB propellants was developed. Theoretical predictions derived from this model show good agreement with experimental data. This model effectively captures the characteristic stress softening and damage evolution in CMDB propellants, thereby providing a theoretical foundation for assessing its mechanical performance and predicting its service life. Full article
(This article belongs to the Section Astronautics & Space Science)
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16 pages, 1473 KB  
Review
Lipid-Mediated Assembly of Biomolecular Condensates: Mechanisms, Regulation, and Therapeutic Implications
by Shijie Ma, Zheng Yang, Chang Du, Binjie Gan and Tong Tang
Biology 2025, 14(9), 1232; https://doi.org/10.3390/biology14091232 - 10 Sep 2025
Viewed by 573
Abstract
Cellular organization relies on both membrane-bound organelles and membraneless biomolecular condensates formed through liquid–liquid phase separation. Recent discoveries reveal intricate coupling between lipid membrane organization and condensate assembly, reshaping our understanding of cellular compartmentalization. This review synthesizes multidisciplinary research using advanced techniques including [...] Read more.
Cellular organization relies on both membrane-bound organelles and membraneless biomolecular condensates formed through liquid–liquid phase separation. Recent discoveries reveal intricate coupling between lipid membrane organization and condensate assembly, reshaping our understanding of cellular compartmentalization. This review synthesizes multidisciplinary research using advanced techniques including super-resolution microscopy, fluorescence recovery after photobleaching, and in vitro reconstitution to examine lipid-condensate interactions. Lipid membranes serve as nucleation platforms that reduce critical concentrations for condensate formation by orders of magnitude through membrane anchoring and thermodynamic coupling, creating specialized microenvironments that substantially enhance enzymatic activities. Key regulatory mechanisms include phosphorylation-driven assembly and disassembly, membrane composition effects from cholesterol content and fatty acid saturation, and environmental factors such as calcium and pH. These interactions drive signal transduction through receptor clustering, membrane trafficking via organized domains, and stress responses through protective condensate formation. Dysregulation of lipid-condensate coupling, including aberrant phase transitions and membrane dysfunction, underlies metabolic disorders and neurodegenerative diseases. This coupling represents a fundamental organizing principle with significant therapeutic potential. Current challenges include developing quantitative methods for characterizing condensate dynamics in complex cellular environments and translating molecular mechanisms into clinical applications. Future progress requires interdisciplinary approaches combining advanced experimental techniques, computational modeling, and standardized protocols to advance both fundamental understanding and therapeutic innovations. Full article
(This article belongs to the Section Biochemistry and Molecular Biology)
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