Search Results (38)

The rapid development of nanotechnology has significantly transformed the design and performance of glucose biosensors, leading to enhanced sensitivity, selectivity, and real-time monitoring capabilities. This review highlights recent advances in glucose-sensing platforms facilitated by nanomaterials, including metal and metal oxide nanoparticles, carbon-based nanostructures, two-dimensional materials, and metal–organic frameworks (MOFs). The integration of these nanoscale materials into electrochemical, optical, and wearable biosensors has addressed longstanding challenges associated with enzyme stability, detection limits, and invasiveness. Special emphasis is placed on non-enzymatic glucose sensors, flexible and wearable devices, and hybrid nanocomposite systems. The multifunctional properties of nanomaterials, such as large surface area, excellent conductivity, and biocompatibility, have enabled the development of next-generation sensors for clinical, point-of-care, and personal healthcare applications. The review also discusses emerging trends such as biodegradable nanosensors, AI-integrated platforms, and smart textiles, which are poised to drive the future of glucose monitoring toward more sustainable and personalized healthcare solutions. Full article

The integration of flexible materials with optical sensing technologies has advanced wearable optical biosensors, offering significant potential in personalized medicine, health monitoring, and disease prevention. This review summarizes the recent advancements in flexible materials for wearable optical biosensors, with a focus on materials such as polymer substrates, nanostructured materials, MXenes, hydrogels, and textile-based integrated platforms. These materials enhance the functionality, sensitivity, and adaptability of sensors, particularly in wearable applications. The review also explores various optical sensing mechanisms, including surface plasmon resonance (SPR), optical fiber sensing, fluorescence sensing, chemiluminescence, and surface-enhanced Raman spectroscopy (SERS), emphasizing their role in improving the detection capabilities for biomarkers, physiological parameters, and environmental pollutants. Despite significant advancements, critical challenges remain in the fabrication and practical deployment of flexible optical biosensors, particularly regarding the long-term stability of materials under dynamic environments, maintaining reliable biocompatibility during prolonged skin contact, and minimizing signal interference caused by motion artifacts and environmental fluctuations. Addressing these issues is vital to ensure robustness and accuracy in real-world applications. Looking forward, future research should emphasize the development of multifunctional and miniaturized devices, the integration of wireless communication and intelligent data analytics, and the improvement of environmental resilience. Such innovations are expected to accelerate the transition of flexible optical biosensors from laboratory research to practical clinical and consumer healthcare applications, paving the way for intelligent health management and early disease diagnostics. Overall, flexible optical biosensors hold great promise in personalized health management, early disease diagnosis, and continuous physiological monitoring, with the potential to revolutionize the healthcare sector. Full article

Wearable and implantable Lab-on-Chip (LoC) biosensors are revolutionizing healthcare by enabling continuous, real-time monitoring of physiological and biochemical parameters in non-clinical settings. These miniaturized platforms integrate sample handling, signal transduction, and data processing on a single chip, facilitating early disease detection, personalized treatment, and preventive care. This review comprehensively explores recent advancements in LoC biosensing technologies, emphasizing their application in skin-mounted patches, smart textiles, and implantable devices. Key innovations in biocompatible materials, nanostructured transducers, and flexible substrates have enabled seamless integration with the human body, while fabrication techniques such as soft lithography, 3D printing, and MEMS have accelerated development. The incorporation of nanomaterials significantly enhances sensitivity and specificity, supporting multiplexed and multi-modal sensing. We examine critical application domains, including glucose monitoring, cardiovascular diagnostics, and neurophysiological assessment. Design considerations related to biocompatibility, power management, data connectivity, and long-term stability are also discussed. Despite promising outcomes, challenges such as biofouling, signal drift, regulatory hurdles, and public acceptance remain. Future directions focus on autonomous systems powered by AI, hybrid wearable–implantable platforms, and wireless energy harvesting. This review highlights the transformative potential of LoC biosensors in shaping the future of smart, patient-centered healthcare through continuous, minimally invasive monitoring. Full article

Next-generation pilot suits are evolving into intelligent, adaptive platforms that integrate advanced polymeric materials, smart textiles, and on-body artificial intelligence. High-performance polymers have advanced in mechanical strength, thermal regulation, and environmental resilience, with fabrication methods like electrospinning, weaving, and 3D/4D printing enabling structural versatility and sensor integration. In particular, functional nanomaterials and hierarchical nanostructures contribute critical properties such as conductivity, flexibility, and responsiveness, forming the foundation for miniaturized sensing and integrated electronics. The integration of flexible fiber-based electronics such as biosensors, strain sensors, and energy systems enables real-time monitoring of physiological and environmental conditions. Coupled with on-body AI for multimodal data processing, autonomous decision-making, and adaptive feedback, these systems enhance pilot safety while reducing cognitive load during flight. This review places a special focus on system-level integration, where polymers and nanomaterials serve as both structural and functional components in wearable technologies. By highlighting the role of nanostructured and functional materials within intelligent textiles, we underline a potential shift toward active human–machine interfaces in aerospace applications. Future trends and advancements in self-healing materials, neuromorphic computing, and dynamic textile systems will further elevate the capabilities of intelligent pilot suits. This review discusses interdisciplinary strategies for developing pilot wearables capable of responding to real-time physiological and operational needs. Full article

Quantifying inflammation plays a critical role in understanding the progression and development of various diseases. Non-invasive or minimally invasive wearable biosensors have garnered significant attention in recent years due to their convenience, comfort, and ability to provide continuous monitoring of biomarkers, particularly in infectious diseases and chronic diseases. However, there are still areas for improvement in developing reliable biosensing devices to detect key inflammatory biomarkers in clinically relevant biofluids. This review first introduces common biofluids with a focus on the most clinically significant inflammatory biomarkers. Specifically, it discusses the challenges encountered in extracting and detecting analytes in these biofluids. Subsequently, we review three popular types of non-invasive wearable biosensors for inflammation monitoring (microneedle patches, flexible electronic skins, and textile-based sensors). The design and operational considerations of these devices are analyzed, followed by an exploration of the information processing approaches employed during data processing. Finally, we envision future opportunities by guiding the development and refinement of non-invasive or minimally invasive wearable biosensors for continuous inflammation monitoring in chronic diseases. Full article

Medical devices have progressed from their initial bulky forms to smart devices. However, their rigidity hampers their seamless integration into everyday life. The fields of stretchable, textile, and flexible electronics are emerging research areas with the potential to drive significant technological progress. This research presents a laboratory-based technique to produce highly sensitive and flexible biosensors for detecting the chikungunya virus. These biosensors are based on 0D nanomaterials and demonstrate significant advancements in voltammetry. The electrochemical platform was created utilizing the stencil printing (StPE) technique. Adapting the biosensor setup involved the selection of aptamer as the biorecognition element bound with silver nanoparticles (AgNPs). This biosensor was employed in the voltammetric identification of the Chikungunya virus antigen (CHIKV-Ag) within a solution containing 0.5 mM potassium ferro/ferri cyanide, a redox pair. The biosensor was employed to evaluate CHIKV-Ag within a human serum sample. It demonstrated a linear detection span ranging from 0.1 ng/mL to 1 μg/mL, with a detection limit of 0.1 ng/mL for CHIKV-Ag. The proposed approach, due to its flexibility in production and the electrocatalytic attributes displayed by the zero-dimensional nanostructure, presents innovative opportunities for cost-effective and tailored aptamer-based bioelectronics, thereby broadening the scope of this domain. Full article

Smart textile-based wearable sweat sensors have recently received a lot of attention due to their potential for use in personal medical monitoring. They have a variety of desirable qualities, including low cost, easy implementation, stretchability, flexibility, and light weight. Wearable sweat sensors are a potential approach for personalized medical devices because of these features. Moreover, real-time textile-based sweat sensors can easily monitor health by analyzing the sweat produced by the human body. We reviewed the most recent advancements in wearable sweat sensors from the fabrication, materials, and disease detection and monitoring perspectives. To integrate real-time biosensors with electronics and introduce advancements to the field of wearable technology, key chemical constituents of sweat, sweat collection technologies, and concerns of textile substrates are elaborated. Perspectives for building wearable biosensing systems based on sweat are reviewed, as well as the methods and difficulties involved in enhancing wearable sweat-sensing performance. Full article

Cashmere and wool are both natural animal fibers used in the textile industry, but cashmere is of superior quality, is rarer, and more precious. It is therefore important to distinguish the two fibers accurately and effectively. However, challenges due to their similar appearance, morphology, and physical and chemical properties remain. Herein, a terahertz electromagnetic inductive transparency (EIT) metasurface biosensor is introduced for qualitative and quantitative identification of cashmere and wool. The periodic unit structure of the metasurface consists of four rotationally symmetric resonators and two cross−arranged metal secants to form toroidal dipoles and electric dipoles, respectively, so that its effective sensing area can be greatly improved by 1075% compared to the traditional dipole mode, and the sensitivity will be up to 342 GHz/RIU. The amplitude and frequency shift changes of the terahertz transmission spectra caused by the different refractive indices of cashmere/wool can achieve highly sensitive label−free qualitative and quantitative identification of both. The experimental results show that the terahertz metasurface biosensor can work at a concentration of 0.02 mg/mL. It provides a new way to achieve high sensitivity, precision, and trace detection of cashmere/wool, and would be a valuable application for the cashmere industry. Full article

In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice. This scoping review aims to assess the performance and safety of novel multi-channel, sensor-based biopotential wearable devices in adults. A comprehensive search strategy was employed on four databases, resulting in 143 records and the inclusion of 12 relevant studies. Most studies focused on healthy adult subjects (n = 6), with some examining controlled groups with atrial fibrillation (AF) (n = 3), long QT syndrome (n = 1), and sleep apnea (n = 1). The investigated bio-sensor devices included chest-worn belts (n = 2), wrist bands (n = 2), adhesive chest strips (n = 2), and wearable textile smart clothes (n = 4). The primary objective of the included studies was to evaluate device performance in terms of accuracy, signal quality, comparability, and visual assessment of ECGs. Safety findings, reported in five articles, indicated no major side effects for long-term/continuous monitoring, with only minor instances of skin irritation. Looking forward, there are ample opportunities to enhance and test these technologies across various physical activity intensities and clinical conditions. Full article

Nanofiber technology is leading the revolution of wearable technology and provides a unique capability to fabricate smart textiles. With the novel fabrication technique of electrospinning, nanofibers can be fabricated and then manufactured into a durable conductive string for the application of smart textiles. This paper presents an electrospun nanofiber mesh-based (NF-Felt) string electrode with a conducting polymer coating for an electrochemical enzymatic glucose sensor. The surface area of a nanofiber matrix is a key physical property for enhanced glucose oxidase (GOx) enzyme binding for the development of an electrochemical biosensor. A morphological characterization of the NF-Felt string electrode was performed using scanning electron microscopy (SEM) and compared with a commercially available cotton–polyester (Cot-Pol) string coated with the same conducting polymer. The results from stress–strain testing demonstrated high stretchability of the NF-Felt string. Also, the electrochemical characterization results showed that the NF-Felt string electrode was able to detect a glucose concentration in the range between 0.0 mM and 30.0 mM with a sensitivity of 37.4 μA/mM·g and a detection limit of 3.31 mM. Overall, with better electrochemical performance and incredible flexibility, the NF-Felt-based string electrode is potentially more suitable for designing wearable biosensors for the detection of glucose in sweat. Full article

Textile-based sensors fabricated using the direct-coating method are the appropriate choice to meet the aspects of flexibility, non-invasiveness, and lightness for continuous monitoring of the human body. The characteristics of the sensor substrate are directly influenced by factors such as the type of weave, thread fineness, fabric density, and the type of polymeric constituent fibers. The fabric used as the sensor substrate, fabricated using the direct-coating method, must be capable of retaining the electrode paste solution, which has higher viscosity, on one surface of the fabric to avoid short circuits during the fabrication process. However, during its application, this fabric should allow the easy passage of analyte solutions with low viscosity as much as possible. Hence, an appropriate fabric construction is required to serve as the substrate for textile-based sensors to ensure the success of the fabrication process and the effectiveness of the resulting sensor’s performance. The development of the structural design of the fabric to be used as a substrate for non-invasive biosensors with a multilayer concept is carried out by weaving and sewing processes utilizing polyester-viscose fibers. During the production process, variations are applied, such as weft yarn density, the characterization of wetting time, absorption rate, maximum wetted radius, spreading speed, and accumulative one-way transport index. The most suitable fabric for use as a substrate for non-invasive biosensors with a multilayer concept, such as in this research, is a fabric with a weft thread density of 70 strands per inch, along with the addition of an analyte transfer thread configuration. Full article

This report aims to provide a patent landscape analysis on carbon allotrope-based textile electrodes and biosensors to measure biosignals and detect several parameters. Espacenet, a free-of-charge patent database provided by the EPO (European Patent Office) and containing data on more than 140 million patent publications from over 100 countries, was used as the reference database. The patent search was carried out by combining keywords and classification symbols. Both classification schemes (IPC–International Patent Classification and CPC–Cooperative Patent Classification) were used. As a result of this study, a total of 227 patent documents were found between 2002 and 2023. The first patent application claiming a fabric electrode arrangement with carbon black as conductive material was filed in 2002 (and published in 2004) by Philips. 2021 was the year with the highest number of published patent applications, with 36 documents. The United States was ranked first with 126 patent documents. Carbon nanotubes and graphene are the most patented carbon allotrope materials, while body temperature, motion, and heart rate measurements are the main disclosed applications. We also analyzed the Orbit database obtaining 288 patent documents (vs. 227) with only 238 still active records (148 granted and 90 pending applications): the first application by Philips on an electrode arrangement is confirmed, and the patent distribution shows a peak in the period 2016–2020 (146 records available), while today it seems to be stable or even decreasing (“only” 52 records in the half period January 2021–June 2023). This outcome suggests that this material and related technology has reached its maximum exploitation or has not demonstrated a disruptive output. Full article

With the innovation of wearable technology and the rapid development of biosensors, wearable biosensors based on flexible textile materials have become a hot topic. Such textile-based wearable biosensors promote the development of health monitoring, motion detection and medical management, and they have become an important support tool for human healthcare monitoring. Textile-based wearable biosensors not only non-invasively monitor various physiological indicators of the human body in real time, but they also provide accurate feedback of individual health information. This review examines the recent research progress of fabric-based wearable biosensors. Moreover, materials, detection principles and fabrication methods for textile-based wearable biosensors are introduced. In addition, the applications of biosensors in monitoring vital signs and detecting body fluids are also presented. Finally, we also discuss several challenges faced by textile-based wearable biosensors and the direction of future development. Full article

The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have necessitated the use of renewable materials, thereby solving the problem of sustainability of resources. In this perspective, lignocellulosic biomass is an attractive natural resource because of its abundance, renewability, recyclability, and low cost. The ever-increasing developments in nanotechnology have opened up new vistas in sensor fabrication such as biosensor design for electronics, communication, automobile, optical products, packaging, textile, biomedical, and tissue engineering. Due to their outstanding properties such as biodegradability, biocompatibility, non-toxicity, improved electrical and thermal conductivity, high physical and mechanical properties, high surface area and catalytic activity, lignocellulosic bionanomaterials including nanocellulose and nanolignin emerge as very promising raw materials to be used in the development of high-impact biosensors. In this article, the use of lignocellulosic bionanomaterials in biosensor applications is reviewed and major challenges and opportunities are identified. Full article